Incidental Mutation 'IGL01712:Vmn1r28'
| ID |
104802 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Vmn1r28
|
| Ensembl Gene |
ENSMUSG00000115705 |
| Gene Name |
vomeronasal 1 receptor 28 |
| Synonyms |
V1rc25 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.133)
|
| Stock # |
IGL01712
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
6 |
| Chromosomal Location |
58239279-58243645 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 58242393 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Alanine
at position 79
(T79A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000153785
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000176874]
[ENSMUST00000226813]
[ENSMUST00000227805]
[ENSMUST00000228678]
|
| AlphaFold |
Q8R2C9 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000176874
AA Change: T79A
PolyPhen 2
Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
|
| SMART Domains |
Protein: ENSMUSP00000135311
Gene: ENSMUSG00000094291
AA Change: T79A
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:V1R
|
28 |
293 |
8.4e-59 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000226813
AA Change: T79A
PolyPhen 2
Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000227805
AA Change: T79A
PolyPhen 2
Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000228678
AA Change: T79A
PolyPhen 2
Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 48 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aadacl2fm3 |
T |
A |
3: 59,776,321 (GRCm39) |
I164N |
possibly damaging |
Het |
| Adgrb3 |
A |
G |
1: 25,865,360 (GRCm39) |
V161A |
probably benign |
Het |
| Arhgdib |
G |
A |
6: 136,901,195 (GRCm39) |
T178M |
probably damaging |
Het |
| Atp11a |
T |
A |
8: 12,901,138 (GRCm39) |
I989K |
probably benign |
Het |
| Bcam |
T |
C |
7: 19,492,692 (GRCm39) |
S498G |
probably damaging |
Het |
| Bcas3 |
A |
G |
11: 85,471,874 (GRCm39) |
I728V |
probably damaging |
Het |
| Cep57 |
G |
T |
9: 13,724,713 (GRCm39) |
P119Q |
possibly damaging |
Het |
| Cimip2a |
T |
C |
2: 25,108,804 (GRCm39) |
|
probably benign |
Het |
| Clip4 |
T |
A |
17: 72,106,036 (GRCm39) |
I73N |
probably damaging |
Het |
| Cpa4 |
A |
G |
6: 30,590,815 (GRCm39) |
D371G |
possibly damaging |
Het |
| Dnah7a |
A |
G |
1: 53,462,429 (GRCm39) |
S3721P |
probably benign |
Het |
| Fcrla |
T |
C |
1: 170,749,192 (GRCm39) |
|
probably null |
Het |
| Foxg1 |
T |
C |
12: 49,432,403 (GRCm39) |
S379P |
possibly damaging |
Het |
| Gatm |
T |
A |
2: 122,431,306 (GRCm39) |
Y227F |
possibly damaging |
Het |
| Grid2 |
A |
T |
6: 64,642,899 (GRCm39) |
D887V |
possibly damaging |
Het |
| Gtpbp6 |
A |
T |
5: 110,252,245 (GRCm39) |
I429N |
probably benign |
Het |
| Ighmbp2 |
A |
G |
19: 3,323,038 (GRCm39) |
|
probably benign |
Het |
| Irs4 |
T |
C |
X: 140,505,395 (GRCm39) |
N934D |
unknown |
Het |
| Kif16b |
T |
A |
2: 142,490,391 (GRCm39) |
N1257I |
probably damaging |
Het |
| L1cam |
T |
C |
X: 72,908,044 (GRCm39) |
Y169C |
probably damaging |
Het |
| L3mbtl3 |
A |
T |
10: 26,152,133 (GRCm39) |
M821K |
probably damaging |
Het |
| Lig3 |
A |
G |
11: 82,680,367 (GRCm39) |
|
probably benign |
Het |
| Lpin2 |
T |
A |
17: 71,522,063 (GRCm39) |
D32E |
probably damaging |
Het |
| Mcoln3 |
T |
C |
3: 145,834,019 (GRCm39) |
|
probably benign |
Het |
| Mgst2 |
T |
C |
3: 51,571,992 (GRCm39) |
V40A |
probably damaging |
Het |
| Mov10l1 |
T |
C |
15: 88,908,969 (GRCm39) |
S997P |
probably damaging |
Het |
| Mycbpap |
G |
T |
11: 94,403,481 (GRCm39) |
H187Q |
possibly damaging |
Het |
| Onecut2 |
T |
A |
18: 64,519,673 (GRCm39) |
S478T |
probably damaging |
Het |
| Or2n1d |
A |
T |
17: 38,646,848 (GRCm39) |
T267S |
probably benign |
Het |
| Or52h7 |
T |
C |
7: 104,214,226 (GRCm39) |
V266A |
probably benign |
Het |
| Pcdhb5 |
A |
T |
18: 37,454,306 (GRCm39) |
I229F |
probably damaging |
Het |
| Pfas |
A |
G |
11: 68,881,886 (GRCm39) |
V933A |
probably benign |
Het |
| Phldb2 |
A |
T |
16: 45,571,792 (GRCm39) |
I1200N |
probably damaging |
Het |
| Pla2g4e |
C |
A |
2: 120,019,884 (GRCm39) |
|
probably null |
Het |
| Prr36 |
G |
A |
8: 4,265,243 (GRCm39) |
P169L |
probably damaging |
Het |
| Rhot2 |
A |
G |
17: 26,060,334 (GRCm39) |
|
probably null |
Het |
| Serpina3f |
C |
T |
12: 104,184,657 (GRCm39) |
P267L |
probably damaging |
Het |
| Sppl2a |
C |
T |
2: 126,746,823 (GRCm39) |
|
probably benign |
Het |
| Tas2r122 |
A |
T |
6: 132,688,725 (GRCm39) |
M56K |
possibly damaging |
Het |
| Tbxas1 |
A |
G |
6: 39,057,994 (GRCm39) |
T450A |
probably benign |
Het |
| Tex16 |
T |
C |
X: 111,003,451 (GRCm39) |
S87P |
probably damaging |
Het |
| Them7 |
T |
A |
2: 105,209,230 (GRCm39) |
F183L |
possibly damaging |
Het |
| Tmbim7 |
A |
G |
5: 3,720,074 (GRCm39) |
T116A |
probably damaging |
Het |
| Tomm40 |
G |
T |
7: 19,437,288 (GRCm39) |
S224R |
probably benign |
Het |
| Top3a |
A |
T |
11: 60,652,562 (GRCm39) |
I84N |
probably damaging |
Het |
| Vmn2r61 |
A |
T |
7: 41,909,661 (GRCm39) |
Y62F |
probably damaging |
Het |
| Zbtb42 |
T |
C |
12: 112,646,718 (GRCm39) |
C298R |
probably benign |
Het |
| Zfp395 |
G |
A |
14: 65,623,836 (GRCm39) |
E102K |
probably damaging |
Het |
|
| Other mutations in Vmn1r28 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01365:Vmn1r28
|
APN |
6 |
58,242,176 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
IGL01788:Vmn1r28
|
APN |
6 |
58,242,522 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02629:Vmn1r28
|
APN |
6 |
58,242,801 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0001:Vmn1r28
|
UTSW |
6 |
58,242,702 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0009:Vmn1r28
|
UTSW |
6 |
58,242,702 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0040:Vmn1r28
|
UTSW |
6 |
58,242,879 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0078:Vmn1r28
|
UTSW |
6 |
58,242,702 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0079:Vmn1r28
|
UTSW |
6 |
58,242,702 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0081:Vmn1r28
|
UTSW |
6 |
58,242,702 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0164:Vmn1r28
|
UTSW |
6 |
58,242,702 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0164:Vmn1r28
|
UTSW |
6 |
58,242,702 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0165:Vmn1r28
|
UTSW |
6 |
58,242,702 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0166:Vmn1r28
|
UTSW |
6 |
58,242,702 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0167:Vmn1r28
|
UTSW |
6 |
58,242,702 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0172:Vmn1r28
|
UTSW |
6 |
58,242,702 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0173:Vmn1r28
|
UTSW |
6 |
58,242,702 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0284:Vmn1r28
|
UTSW |
6 |
58,242,702 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0288:Vmn1r28
|
UTSW |
6 |
58,242,702 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0704:Vmn1r28
|
UTSW |
6 |
58,242,702 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1143:Vmn1r28
|
UTSW |
6 |
58,242,727 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1225:Vmn1r28
|
UTSW |
6 |
58,242,951 (GRCm39) |
nonsense |
probably null |
|
|
R1464:Vmn1r28
|
UTSW |
6 |
58,242,217 (GRCm39) |
missense |
probably benign |
0.05 |
|
R1464:Vmn1r28
|
UTSW |
6 |
58,242,217 (GRCm39) |
missense |
probably benign |
0.05 |
|
R1836:Vmn1r28
|
UTSW |
6 |
58,242,237 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1882:Vmn1r28
|
UTSW |
6 |
58,242,963 (GRCm39) |
missense |
probably benign |
|
|
R1905:Vmn1r28
|
UTSW |
6 |
58,242,912 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4912:Vmn1r28
|
UTSW |
6 |
58,242,525 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R5071:Vmn1r28
|
UTSW |
6 |
58,242,894 (GRCm39) |
missense |
probably benign |
0.25 |
|
R5113:Vmn1r28
|
UTSW |
6 |
58,242,843 (GRCm39) |
missense |
probably benign |
0.12 |
|
R5261:Vmn1r28
|
UTSW |
6 |
58,242,524 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5265:Vmn1r28
|
UTSW |
6 |
58,242,949 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5839:Vmn1r28
|
UTSW |
6 |
58,242,280 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R6180:Vmn1r28
|
UTSW |
6 |
58,242,476 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6643:Vmn1r28
|
UTSW |
6 |
58,242,945 (GRCm39) |
missense |
probably benign |
0.17 |
|
R6884:Vmn1r28
|
UTSW |
6 |
58,242,633 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7393:Vmn1r28
|
UTSW |
6 |
58,242,574 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R7471:Vmn1r28
|
UTSW |
6 |
58,242,850 (GRCm39) |
nonsense |
probably null |
|
|
R7738:Vmn1r28
|
UTSW |
6 |
58,243,039 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7961:Vmn1r28
|
UTSW |
6 |
58,242,178 (GRCm39) |
missense |
probably benign |
|
|
R8009:Vmn1r28
|
UTSW |
6 |
58,242,178 (GRCm39) |
missense |
probably benign |
|
|
R8156:Vmn1r28
|
UTSW |
6 |
58,242,183 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8167:Vmn1r28
|
UTSW |
6 |
58,243,052 (GRCm39) |
missense |
noncoding transcript |
|
|
R8879:Vmn1r28
|
UTSW |
6 |
58,242,669 (GRCm39) |
missense |
probably benign |
0.05 |
|
R9639:Vmn1r28
|
UTSW |
6 |
58,242,996 (GRCm39) |
nonsense |
probably null |
|
|
| Posted On |
2014-01-21 |
Incidental Mutation