Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01712:Aadacl2fm3'

104821

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Aadacl2fm3

Ensembl Gene

ENSMUSG00000095522

Gene Name

AADACL2 family member 3

Synonyms

Gm8298

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.068) question?

Stock #

IGL01712

Quality Score

Status

Chromosome

Chromosomal Location

59768472-59784734 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 59776321 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Asparagine at position 164 (I164N)

Ref Sequence

ENSEMBL: ENSMUSP00000137307 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000179799]

AlphaFold

J3QPI0

Predicted Effect

possibly damaging
Transcript: ENSMUST00000179799
AA Change: I164N

PolyPhen 2 Score 0.797 (Sensitivity: 0.84; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000137307
Gene: ENSMUSG00000095522
AA Change: I164N

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:COesterase	91	217	9.6e-7	PFAM
Pfam:Abhydrolase_3	107	279	1.1e-36	PFAM
Pfam:Abhydrolase_3	284	375	1.2e-11	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000194941

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 48 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adgrb3	A	G	1: 25,865,360 (GRCm39)	V161A	probably benign	Het
Arhgdib	G	A	6: 136,901,195 (GRCm39)	T178M	probably damaging	Het
Atp11a	T	A	8: 12,901,138 (GRCm39)	I989K	probably benign	Het
Bcam	T	C	7: 19,492,692 (GRCm39)	S498G	probably damaging	Het
Bcas3	A	G	11: 85,471,874 (GRCm39)	I728V	probably damaging	Het
Cep57	G	T	9: 13,724,713 (GRCm39)	P119Q	possibly damaging	Het
Cimip2a	T	C	2: 25,108,804 (GRCm39)		probably benign	Het
Clip4	T	A	17: 72,106,036 (GRCm39)	I73N	probably damaging	Het
Cpa4	A	G	6: 30,590,815 (GRCm39)	D371G	possibly damaging	Het
Dnah7a	A	G	1: 53,462,429 (GRCm39)	S3721P	probably benign	Het
Fcrla	T	C	1: 170,749,192 (GRCm39)		probably null	Het
Foxg1	T	C	12: 49,432,403 (GRCm39)	S379P	possibly damaging	Het
Gatm	T	A	2: 122,431,306 (GRCm39)	Y227F	possibly damaging	Het
Grid2	A	T	6: 64,642,899 (GRCm39)	D887V	possibly damaging	Het
Gtpbp6	A	T	5: 110,252,245 (GRCm39)	I429N	probably benign	Het
Ighmbp2	A	G	19: 3,323,038 (GRCm39)		probably benign	Het
Irs4	T	C	X: 140,505,395 (GRCm39)	N934D	unknown	Het
Kif16b	T	A	2: 142,490,391 (GRCm39)	N1257I	probably damaging	Het
L1cam	T	C	X: 72,908,044 (GRCm39)	Y169C	probably damaging	Het
L3mbtl3	A	T	10: 26,152,133 (GRCm39)	M821K	probably damaging	Het
Lig3	A	G	11: 82,680,367 (GRCm39)		probably benign	Het
Lpin2	T	A	17: 71,522,063 (GRCm39)	D32E	probably damaging	Het
Mcoln3	T	C	3: 145,834,019 (GRCm39)		probably benign	Het
Mgst2	T	C	3: 51,571,992 (GRCm39)	V40A	probably damaging	Het
Mov10l1	T	C	15: 88,908,969 (GRCm39)	S997P	probably damaging	Het
Mycbpap	G	T	11: 94,403,481 (GRCm39)	H187Q	possibly damaging	Het
Onecut2	T	A	18: 64,519,673 (GRCm39)	S478T	probably damaging	Het
Or2n1d	A	T	17: 38,646,848 (GRCm39)	T267S	probably benign	Het
Or52h7	T	C	7: 104,214,226 (GRCm39)	V266A	probably benign	Het
Pcdhb5	A	T	18: 37,454,306 (GRCm39)	I229F	probably damaging	Het
Pfas	A	G	11: 68,881,886 (GRCm39)	V933A	probably benign	Het
Phldb2	A	T	16: 45,571,792 (GRCm39)	I1200N	probably damaging	Het
Pla2g4e	C	A	2: 120,019,884 (GRCm39)		probably null	Het
Prr36	G	A	8: 4,265,243 (GRCm39)	P169L	probably damaging	Het
Rhot2	A	G	17: 26,060,334 (GRCm39)		probably null	Het
Serpina3f	C	T	12: 104,184,657 (GRCm39)	P267L	probably damaging	Het
Sppl2a	C	T	2: 126,746,823 (GRCm39)		probably benign	Het
Tas2r122	A	T	6: 132,688,725 (GRCm39)	M56K	possibly damaging	Het
Tbxas1	A	G	6: 39,057,994 (GRCm39)	T450A	probably benign	Het
Tex16	T	C	X: 111,003,451 (GRCm39)	S87P	probably damaging	Het
Them7	T	A	2: 105,209,230 (GRCm39)	F183L	possibly damaging	Het
Tmbim7	A	G	5: 3,720,074 (GRCm39)	T116A	probably damaging	Het
Tomm40	G	T	7: 19,437,288 (GRCm39)	S224R	probably benign	Het
Top3a	A	T	11: 60,652,562 (GRCm39)	I84N	probably damaging	Het
Vmn1r28	A	G	6: 58,242,393 (GRCm39)	T79A	probably benign	Het
Vmn2r61	A	T	7: 41,909,661 (GRCm39)	Y62F	probably damaging	Het
Zbtb42	T	C	12: 112,646,718 (GRCm39)	C298R	probably benign	Het
Zfp395	G	A	14: 65,623,836 (GRCm39)	E102K	probably damaging	Het

Other mutations in Aadacl2fm3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02064:Aadacl2fm3	APN	3	59,784,463 (GRCm39)	missense	probably damaging	1.00
IGL02317:Aadacl2fm3	APN	3	59,784,408 (GRCm39)	missense	probably benign	0.00
R0270:Aadacl2fm3	UTSW	3	59,784,440 (GRCm39)	missense	probably benign
R0580:Aadacl2fm3	UTSW	3	59,784,470 (GRCm39)	missense	probably damaging	1.00
R1124:Aadacl2fm3	UTSW	3	59,772,639 (GRCm39)	missense	probably benign	0.39
R1208:Aadacl2fm3	UTSW	3	59,772,715 (GRCm39)	missense	probably benign	0.27
R1208:Aadacl2fm3	UTSW	3	59,772,715 (GRCm39)	missense	probably benign	0.27
R1222:Aadacl2fm3	UTSW	3	59,784,682 (GRCm39)	nonsense	probably null
R1436:Aadacl2fm3	UTSW	3	59,772,760 (GRCm39)	missense	probably damaging	0.98
R1529:Aadacl2fm3	UTSW	3	59,768,533 (GRCm39)	missense	probably benign
R1806:Aadacl2fm3	UTSW	3	59,784,571 (GRCm39)	missense	probably damaging	1.00
R2130:Aadacl2fm3	UTSW	3	59,772,769 (GRCm39)	missense	probably damaging	1.00
R4209:Aadacl2fm3	UTSW	3	59,784,577 (GRCm39)	missense	probably damaging	1.00
R4597:Aadacl2fm3	UTSW	3	59,784,214 (GRCm39)	missense	possibly damaging	0.47
R4910:Aadacl2fm3	UTSW	3	59,776,435 (GRCm39)	critical splice donor site	probably null
R5571:Aadacl2fm3	UTSW	3	59,784,640 (GRCm39)	missense	probably damaging	1.00
R6131:Aadacl2fm3	UTSW	3	59,776,324 (GRCm39)	missense	possibly damaging	0.76
R6447:Aadacl2fm3	UTSW	3	59,772,819 (GRCm39)	missense	probably damaging	0.99
R6481:Aadacl2fm3	UTSW	3	59,768,478 (GRCm39)	missense	probably benign	0.00
R6795:Aadacl2fm3	UTSW	3	59,776,357 (GRCm39)	missense	probably damaging	1.00
R7092:Aadacl2fm3	UTSW	3	59,768,500 (GRCm39)	missense	probably benign	0.41
R7334:Aadacl2fm3	UTSW	3	59,776,380 (GRCm39)	missense	probably damaging	1.00
R7602:Aadacl2fm3	UTSW	3	59,784,697 (GRCm39)	missense	probably benign	0.17
R7660:Aadacl2fm3	UTSW	3	59,772,689 (GRCm39)	missense	probably benign	0.05
R7705:Aadacl2fm3	UTSW	3	59,784,168 (GRCm39)	missense	probably benign	0.25
R7708:Aadacl2fm3	UTSW	3	59,772,756 (GRCm39)	missense	probably benign	0.00
R7981:Aadacl2fm3	UTSW	3	59,784,360 (GRCm39)	missense	probably damaging	1.00
R8167:Aadacl2fm3	UTSW	3	59,784,632 (GRCm39)	missense	probably benign	0.03
R8941:Aadacl2fm3	UTSW	3	59,784,400 (GRCm39)	missense	probably damaging	1.00
R9547:Aadacl2fm3	UTSW	3	59,772,656 (GRCm39)	missense	probably benign	0.00
R9557:Aadacl2fm3	UTSW	3	59,784,654 (GRCm39)	missense	possibly damaging	0.81
R9675:Aadacl2fm3	UTSW	3	59,784,538 (GRCm39)	missense	probably damaging	1.00
X0011:Aadacl2fm3	UTSW	3	59,768,598 (GRCm39)	missense	probably benign
X0022:Aadacl2fm3	UTSW	3	59,784,445 (GRCm39)	missense	probably benign	0.01

Posted On

2014-01-21