Incidental Mutation 'IGL01713:Igkv12-89'
ID104869
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Igkv12-89
Ensembl Gene ENSMUSG00000076534
Gene Nameimmunoglobulin kappa chain variable 12-89
SynonymsGm16905
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.104) question?
Stock #IGL01713
Quality Score
Status
Chromosome6
Chromosomal Location68834846-68835307 bp(-) (GRCm38)
Type of Mutationunclassified
DNA Base Change (assembly) G to T at 68835312 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000143728 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000103335] [ENSMUST00000199143]
Predicted Effect probably benign
Transcript: ENSMUST00000103335
SMART Domains Protein: ENSMUSP00000100136
Gene: ENSMUSG00000076534

DomainStartEndE-ValueType
IGv 34 106 2.62e-16 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000199143
SMART Domains Protein: ENSMUSP00000143728
Gene: ENSMUSG00000076534

DomainStartEndE-ValueType
signal peptide 1 17 N/A INTRINSIC
IGv 35 107 1.1e-18 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 24 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933402N03Rik A G 7: 131,139,043 I148T possibly damaging Het
Aipl1 A G 11: 72,036,623 C89R probably damaging Het
Apaf1 G A 10: 91,061,832 probably benign Het
Atp7b A G 8: 22,028,573 V83A probably damaging Het
Ccdc180 G T 4: 45,921,025 probably null Het
Crebbp T C 16: 4,128,648 I418V possibly damaging Het
Cyp26b1 G A 6: 84,574,301 P427L probably benign Het
Dnal4 A G 15: 79,762,405 Y92H probably damaging Het
Dpy19l1 C T 9: 24,485,069 R117Q probably damaging Het
Epha3 G A 16: 63,552,562 T926I probably benign Het
Fgg T C 3: 83,008,416 S55P probably benign Het
Gosr1 A T 11: 76,754,756 M66K probably benign Het
Map3k12 T C 15: 102,502,321 E451G probably damaging Het
Phkg1 T C 5: 129,866,873 E179G probably benign Het
Pnpla1 A T 17: 28,881,605 D482V possibly damaging Het
Pramel1 T C 4: 143,397,082 V109A probably benign Het
Prr36 G A 8: 4,215,243 P169L probably damaging Het
Pus7l T C 15: 94,531,612 T442A probably benign Het
Sall3 A G 18: 80,969,847 S1125P probably damaging Het
Scyl2 A C 10: 89,654,225 I150S probably damaging Het
Sf1 T A 19: 6,374,289 probably null Het
Slco1a6 A G 6: 142,086,567 S611P possibly damaging Het
Vmn2r103 G T 17: 19,794,068 C374F probably damaging Het
Xntrpc T C 7: 102,083,852 probably benign Het
Other mutations in Igkv12-89
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01150:Igkv12-89 APN 6 68835143 missense probably benign 0.00
IGL02364:Igkv12-89 APN 6 68834986 nonsense probably null
FR4449:Igkv12-89 UTSW 6 68835280 small insertion probably benign
R7110:Igkv12-89 UTSW 6 68835131 missense probably damaging 1.00
R7283:Igkv12-89 UTSW 6 68835077 missense probably damaging 1.00
R7637:Igkv12-89 UTSW 6 68835099 missense probably benign 0.26
RF014:Igkv12-89 UTSW 6 68835286 small insertion probably benign
RF042:Igkv12-89 UTSW 6 68835286 small insertion probably benign
Posted On2014-01-21