Incidental Mutation 'IGL01717:Lrrc39'
ID104989
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Lrrc39
Ensembl Gene ENSMUSG00000027961
Gene Nameleucine rich repeat containing 39
Synonyms2010005E21Rik, 9430028I06Rik
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.383) question?
Stock #IGL01717
Quality Score
Status
Chromosome3
Chromosomal Location116562973-116583134 bp(+) (GRCm38)
Type of Mutationunclassified
DNA Base Change (assembly) A to T at 116579497 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000138868 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000029573] [ENSMUST00000041524] [ENSMUST00000183638] [ENSMUST00000184963]
Predicted Effect probably benign
Transcript: ENSMUST00000029573
SMART Domains Protein: ENSMUSP00000029573
Gene: ENSMUSG00000027961

DomainStartEndE-ValueType
LRR 105 127 1.15e1 SMART
LRR_TYP 128 151 7.26e-3 SMART
LRR 175 197 6.58e0 SMART
LRR 198 220 1e1 SMART
LRR 221 243 7.16e0 SMART
LRR 244 267 6.58e0 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000041524
SMART Domains Protein: ENSMUSP00000047320
Gene: ENSMUSG00000033439

DomainStartEndE-ValueType
Pfam:zf-TRM13_CCCH 17 45 7.2e-17 PFAM
Pfam:zf-U11-48K 56 80 3.4e-12 PFAM
Pfam:TRM13 165 469 7e-96 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000156161
Predicted Effect probably benign
Transcript: ENSMUST00000183638
SMART Domains Protein: ENSMUSP00000139223
Gene: ENSMUSG00000033439

DomainStartEndE-ValueType
Pfam:zf-TRM13_CCCH 16 46 1.4e-17 PFAM
Pfam:zf-U11-48K 55 81 1.2e-12 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000184963
SMART Domains Protein: ENSMUSP00000138868
Gene: ENSMUSG00000033439

DomainStartEndE-ValueType
Pfam:zf-TRM13_CCCH 16 46 2.9e-17 PFAM
Pfam:zf-U11-48K 55 81 2.3e-12 PFAM
Pfam:TRM13 165 285 3.4e-42 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000199439
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4932438A13Rik A G 3: 37,034,736 S4112G probably benign Het
Aif1 A T 17: 35,171,555 M73K probably damaging Het
Alk T C 17: 72,603,382 I110V probably benign Het
Aoah T C 13: 20,999,977 S404P probably damaging Het
Bhlhe41 A G 6: 145,863,037 S350P possibly damaging Het
Capn12 A G 7: 28,889,105 D540G probably benign Het
Chd6 A G 2: 160,965,259 Y2012H possibly damaging Het
Col1a1 A G 11: 94,950,777 T1284A unknown Het
Col24a1 T C 3: 145,524,263 probably benign Het
Col4a5 T A X: 141,639,238 V1070D unknown Het
Col6a5 T C 9: 105,940,273 T280A unknown Het
Dicer1 A T 12: 104,702,787 L1212* probably null Het
Gigyf1 T A 5: 137,525,691 V1041E probably damaging Het
Gm4978 C T 9: 69,450,873 probably benign Het
Gnai1 A G 5: 18,291,461 probably null Het
Golgb1 C T 16: 36,915,502 R1704* probably null Het
Incenp A G 19: 9,893,265 probably benign Het
Man2a2 T C 7: 80,367,365 K319E probably damaging Het
Neb T C 2: 52,189,867 D83G probably damaging Het
Osbpl6 T C 2: 76,588,594 I732T probably damaging Het
Pacs1 T A 19: 5,167,972 K130N probably damaging Het
Pappa2 A G 1: 158,857,132 probably null Het
Pole2 T C 12: 69,213,849 M186V probably damaging Het
Rwdd4a T C 8: 47,544,105 probably benign Het
Sel1l3 A G 5: 53,200,168 Y161H probably damaging Het
Sf3a2 C T 10: 80,804,692 Q446* probably null Het
Slc26a3 T C 12: 31,463,477 I466T probably benign Het
Slc29a4 A T 5: 142,718,746 I348F probably damaging Het
Tbl1xr1 A G 3: 22,193,171 probably benign Het
Tlr5 A T 1: 182,975,398 I756F probably damaging Het
Ttn T A 2: 76,730,402 L29218F probably damaging Het
Ttn A T 2: 76,730,404 L29218I probably damaging Het
Other mutations in Lrrc39
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00340:Lrrc39 APN 3 116570981 splice site probably benign
IGL01017:Lrrc39 APN 3 116570851 missense probably benign 0.01
IGL01728:Lrrc39 APN 3 116579500 unclassified probably benign
IGL02208:Lrrc39 APN 3 116578274 missense probably damaging 1.00
IGL02801:Lrrc39 APN 3 116578346 missense possibly damaging 0.89
R0279:Lrrc39 UTSW 3 116578303 missense probably benign 0.19
R1351:Lrrc39 UTSW 3 116565820 missense possibly damaging 0.51
R1436:Lrrc39 UTSW 3 116579644 splice site probably null
R1641:Lrrc39 UTSW 3 116570913 missense probably damaging 0.99
R1716:Lrrc39 UTSW 3 116579567 missense probably benign 0.00
R2199:Lrrc39 UTSW 3 116570961 missense probably damaging 0.97
R2410:Lrrc39 UTSW 3 116581250 missense probably benign 0.02
R4696:Lrrc39 UTSW 3 116570120 missense probably damaging 1.00
R4816:Lrrc39 UTSW 3 116568866 critical splice donor site probably null
R5076:Lrrc39 UTSW 3 116579540 missense probably benign 0.37
R6152:Lrrc39 UTSW 3 116570975 critical splice donor site probably null
R7124:Lrrc39 UTSW 3 116565913 missense probably benign
X0028:Lrrc39 UTSW 3 116565871 missense probably damaging 1.00
Posted On2014-01-21