Incidental Mutation 'IGL01718:Olfr835'
ID104995
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr835
Ensembl Gene ENSMUSG00000045204
Gene Nameolfactory receptor 835
SynonymsMOR150-3, GA_x6K02T2PVTD-12771995-12772930
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.125) question?
Stock #IGL01718
Quality Score
Status
Chromosome9
Chromosomal Location19032735-19037670 bp(+) (GRCm38)
Type of Mutationnonsense
DNA Base Change (assembly) T to A at 19035288 bp
ZygosityHeterozygous
Amino Acid Change Leucine to Stop codon at position 55 (L55*)
Ref Sequence ENSEMBL: ENSMUSP00000148416 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000059315] [ENSMUST00000213018]
Predicted Effect probably null
Transcript: ENSMUST00000059315
AA Change: L55*
SMART Domains Protein: ENSMUSP00000052610
Gene: ENSMUSG00000045204
AA Change: L55*

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 1.8e-47 PFAM
Pfam:7TM_GPCR_Srsx 35 206 2.9e-7 PFAM
Pfam:7tm_1 41 303 1.3e-23 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000213018
AA Change: L55*
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 28 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aldh1a3 A G 7: 66,400,205 F422L possibly damaging Het
Ap2m1 T C 16: 20,542,194 probably benign Het
Asic1 A G 15: 99,672,002 Y68C probably damaging Het
Ccdc18 A G 5: 108,201,348 D1002G possibly damaging Het
Cyp2c29 A T 19: 39,330,260 I434F possibly damaging Het
Diaph3 T A 14: 86,656,338 R78S unknown Het
Dnase1l2 T C 17: 24,441,716 D188G possibly damaging Het
Exosc9 T C 3: 36,553,929 probably benign Het
Fgf23 G A 6: 127,080,473 V251I probably benign Het
Fndc3c1 T C X: 106,445,928 T296A probably benign Het
Gm5592 A G 7: 41,289,193 E633G probably damaging Het
Gm7102 A G 19: 61,175,761 S79P probably damaging Het
Gpr155 T C 2: 73,382,232 M16V probably benign Het
Jakmip3 T G 7: 138,989,392 S2A possibly damaging Het
Lrba T A 3: 86,351,248 N1347K probably damaging Het
Mars T C 10: 127,305,838 R266G possibly damaging Het
Mrgpra1 A T 7: 47,335,927 probably null Het
Pdzk1ip1 T A 4: 115,092,914 probably benign Het
Ppid G T 3: 79,593,679 C52F probably damaging Het
Reln A G 5: 21,947,514 I2318T possibly damaging Het
Rhpn2 G A 7: 35,370,754 D146N probably benign Het
Tspoap1 G T 11: 87,780,255 R1670L possibly damaging Het
Ttc22 G A 4: 106,638,576 V376M probably damaging Het
Ttn T A 2: 76,730,402 L29218F probably damaging Het
Ttn A T 2: 76,730,404 L29218I probably damaging Het
Zfp609 G A 9: 65,702,400 Q1094* probably null Het
Zfp831 C T 2: 174,643,838 T102I possibly damaging Het
Zglp1 C T 9: 21,063,379 C171Y probably benign Het
Other mutations in Olfr835
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02546:Olfr835 APN 9 19035354 missense possibly damaging 0.88
R0010:Olfr835 UTSW 9 19035322 missense probably damaging 1.00
R0107:Olfr835 UTSW 9 19035333 missense probably damaging 1.00
R1867:Olfr835 UTSW 9 19035266 missense probably benign 0.36
R1891:Olfr835 UTSW 9 19035978 missense probably damaging 0.99
R1941:Olfr835 UTSW 9 19035866 missense possibly damaging 0.93
R4152:Olfr835 UTSW 9 19035520 nonsense probably null
R5451:Olfr835 UTSW 9 19035491 missense probably damaging 1.00
R5677:Olfr835 UTSW 9 19035558 missense possibly damaging 0.93
R5970:Olfr835 UTSW 9 19035147 missense probably benign
R6187:Olfr835 UTSW 9 19035393 missense probably benign 0.12
R6805:Olfr835 UTSW 9 19035301 missense probably damaging 1.00
R7183:Olfr835 UTSW 9 19035332 missense probably damaging 1.00
R8029:Olfr835 UTSW 9 19035794 missense probably damaging 1.00
Posted On2014-01-21