Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01718:Zfp609'

104998

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp609

Ensembl Gene

ENSMUSG00000040524

Gene Name

zinc finger protein 609

Synonyms

Accession Numbers

Essential gene?

Possibly essential (E-score: 0.620) question?

Stock #

IGL01718

Quality Score

Status

Chromosome

Chromosomal Location

65599673-65734846 bp(-) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

G to A at 65609682 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glutamine to Stop codon at position 1094 (Q1094*)

Ref Sequence

ENSEMBL: ENSMUSP00000124089 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000159109]

AlphaFold

Q8BZ47

Predicted Effect

probably null
Transcript: ENSMUST00000159109
AA Change: Q1094*

SMART Domains

Protein: ENSMUSP00000124089
Gene: ENSMUSG00000040524
AA Change: Q1094*

Domain	Start	End	E-Value	Type
low complexity region	83	101	N/A	INTRINSIC
low complexity region	125	139	N/A	INTRINSIC
low complexity region	155	176	N/A	INTRINSIC
low complexity region	259	269	N/A	INTRINSIC
low complexity region	365	376	N/A	INTRINSIC
low complexity region	386	405	N/A	INTRINSIC
ZnF_C2H2	495	520	2.14e0	SMART
low complexity region	629	638	N/A	INTRINSIC
low complexity region	657	667	N/A	INTRINSIC
low complexity region	724	738	N/A	INTRINSIC
low complexity region	1000	1020	N/A	INTRINSIC
low complexity region	1210	1219	N/A	INTRINSIC
low complexity region	1257	1273	N/A	INTRINSIC
low complexity region	1329	1348	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000159878

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 28 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aldh1a3	A	G	7: 66,049,953 (GRCm39)	F422L	possibly damaging	Het
Ap2m1	T	C	16: 20,360,944 (GRCm39)		probably benign	Het
Asic1	A	G	15: 99,569,883 (GRCm39)	Y68C	probably damaging	Het
Ccdc18	A	G	5: 108,349,214 (GRCm39)	D1002G	possibly damaging	Het
Cyp2c29	A	T	19: 39,318,704 (GRCm39)	I434F	possibly damaging	Het
Diaph3	T	A	14: 86,893,774 (GRCm39)	R78S	unknown	Het
Dnase1l2	T	C	17: 24,660,690 (GRCm39)	D188G	possibly damaging	Het
Exosc9	T	C	3: 36,608,078 (GRCm39)		probably benign	Het
Fgf23	G	A	6: 127,057,436 (GRCm39)	V251I	probably benign	Het
Fndc3c1	T	C	X: 105,489,534 (GRCm39)	T296A	probably benign	Het
Gm5592	A	G	7: 40,938,617 (GRCm39)	E633G	probably damaging	Het
Gpr155	T	C	2: 73,212,576 (GRCm39)	M16V	probably benign	Het
Jakmip3	T	G	7: 138,591,121 (GRCm39)	S2A	possibly damaging	Het
Lrba	T	A	3: 86,258,555 (GRCm39)	N1347K	probably damaging	Het
Mars1	T	C	10: 127,141,707 (GRCm39)	R266G	possibly damaging	Het
Mplkipl1	A	G	19: 61,164,199 (GRCm39)	S79P	probably damaging	Het
Mrgpra1	A	T	7: 46,985,675 (GRCm39)		probably null	Het
Or7g20	T	A	9: 18,946,584 (GRCm39)	L55*	probably null	Het
Pdzk1ip1	T	A	4: 114,950,111 (GRCm39)		probably benign	Het
Ppid	G	T	3: 79,500,986 (GRCm39)	C52F	probably damaging	Het
Reln	A	G	5: 22,152,512 (GRCm39)	I2318T	possibly damaging	Het
Rhpn2	G	A	7: 35,070,179 (GRCm39)	D146N	probably benign	Het
Tspoap1	G	T	11: 87,671,081 (GRCm39)	R1670L	possibly damaging	Het
Ttc22	G	A	4: 106,495,773 (GRCm39)	V376M	probably damaging	Het
Ttn	T	A	2: 76,560,746 (GRCm39)	L29218F	probably damaging	Het
Ttn	A	T	2: 76,560,748 (GRCm39)	L29218I	probably damaging	Het
Zfp831	C	T	2: 174,485,631 (GRCm39)	T102I	possibly damaging	Het
Zglp1	C	T	9: 20,974,675 (GRCm39)	C171Y	probably benign	Het

Other mutations in Zfp609

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00956:Zfp609	APN	9	65,610,045 (GRCm39)	missense	probably benign	0.18
IGL01688:Zfp609	APN	9	65,611,307 (GRCm39)	missense	probably benign
IGL01860:Zfp609	APN	9	65,610,116 (GRCm39)	missense	possibly damaging	0.82
IGL02441:Zfp609	APN	9	65,610,611 (GRCm39)	missense	possibly damaging	0.92
IGL02490:Zfp609	APN	9	65,611,250 (GRCm39)	missense	possibly damaging	0.92
IGL02614:Zfp609	APN	9	65,610,072 (GRCm39)	missense	probably damaging	0.96
IGL02794:Zfp609	APN	9	65,611,602 (GRCm39)	missense	possibly damaging	0.83
IGL02959:Zfp609	APN	9	65,610,675 (GRCm39)	missense	probably benign
IGL02967:Zfp609	APN	9	65,604,901 (GRCm39)	missense	possibly damaging	0.83
IGL03036:Zfp609	APN	9	65,609,927 (GRCm39)	missense	possibly damaging	0.89
IGL03182:Zfp609	APN	9	65,608,287 (GRCm39)	missense	probably benign	0.02
H8441:Zfp609	UTSW	9	65,702,169 (GRCm39)	missense	possibly damaging	0.82
R0304:Zfp609	UTSW	9	65,608,470 (GRCm39)	missense	possibly damaging	0.89
R0487:Zfp609	UTSW	9	65,609,916 (GRCm39)	missense	unknown
R0505:Zfp609	UTSW	9	65,610,744 (GRCm39)	missense	possibly damaging	0.92
R0684:Zfp609	UTSW	9	65,638,483 (GRCm39)	missense	probably benign	0.01
R1480:Zfp609	UTSW	9	65,610,593 (GRCm39)	missense	possibly damaging	0.82
R1507:Zfp609	UTSW	9	65,702,059 (GRCm39)	missense	possibly damaging	0.92
R1579:Zfp609	UTSW	9	65,611,754 (GRCm39)	missense	possibly damaging	0.90
R1655:Zfp609	UTSW	9	65,610,836 (GRCm39)	missense	possibly damaging	0.46
R1692:Zfp609	UTSW	9	65,702,593 (GRCm39)	missense	probably damaging	0.98
R1701:Zfp609	UTSW	9	65,638,282 (GRCm39)	missense	probably benign	0.05
R1735:Zfp609	UTSW	9	65,610,374 (GRCm39)	nonsense	probably null
R1883:Zfp609	UTSW	9	65,702,040 (GRCm39)	missense	probably benign
R1970:Zfp609	UTSW	9	65,702,559 (GRCm39)	missense	probably damaging	0.96
R2059:Zfp609	UTSW	9	65,611,716 (GRCm39)	missense	possibly damaging	0.83
R2302:Zfp609	UTSW	9	65,702,179 (GRCm39)	missense	possibly damaging	0.66
R3404:Zfp609	UTSW	9	65,608,454 (GRCm39)	missense	possibly damaging	0.68
R3405:Zfp609	UTSW	9	65,608,454 (GRCm39)	missense	possibly damaging	0.68
R4514:Zfp609	UTSW	9	65,610,977 (GRCm39)	missense	possibly damaging	0.46
R4533:Zfp609	UTSW	9	65,610,890 (GRCm39)	missense	probably benign	0.00
R5043:Zfp609	UTSW	9	65,608,109 (GRCm39)	missense	probably damaging	0.97
R5499:Zfp609	UTSW	9	65,610,137 (GRCm39)	missense	probably benign	0.00
R7081:Zfp609	UTSW	9	65,609,723 (GRCm39)	missense	possibly damaging	0.46
R7514:Zfp609	UTSW	9	65,613,418 (GRCm39)	missense	probably benign	0.05
R7677:Zfp609	UTSW	9	65,604,456 (GRCm39)	missense	possibly damaging	0.61
R7684:Zfp609	UTSW	9	65,638,362 (GRCm39)	missense	possibly damaging	0.66
R8229:Zfp609	UTSW	9	65,610,782 (GRCm39)	missense	possibly damaging	0.66
R8266:Zfp609	UTSW	9	65,610,996 (GRCm39)	missense	possibly damaging	0.66
R8278:Zfp609	UTSW	9	65,604,804 (GRCm39)	missense	possibly damaging	0.90
R8934:Zfp609	UTSW	9	65,610,561 (GRCm39)	missense	possibly damaging	0.90
R8938:Zfp609	UTSW	9	65,610,561 (GRCm39)	missense	possibly damaging	0.90
R8940:Zfp609	UTSW	9	65,610,561 (GRCm39)	missense	possibly damaging	0.90
R8986:Zfp609	UTSW	9	65,610,561 (GRCm39)	missense	possibly damaging	0.90
R9267:Zfp609	UTSW	9	65,608,328 (GRCm39)	missense	possibly damaging	0.90
R9456:Zfp609	UTSW	9	65,611,125 (GRCm39)	missense
R9561:Zfp609	UTSW	9	65,604,512 (GRCm39)	nonsense	probably null
X0028:Zfp609	UTSW	9	65,604,362 (GRCm39)	small deletion	probably benign

Posted On

2014-01-21