Incidental Mutation 'IGL00162:Mok'
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Mok
Ensembl Gene ENSMUSG00000056458
Gene NameMOK protein kinase
SynonymsStk30, MAPK/MAK/MRK/ overlapping kinase, MOK, Rage
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.129) question?
Stock #IGL00162
Quality Score
Chromosomal Location110807798-110840939 bp(-) (GRCm38)
Type of Mutationunclassified
DNA Base Change (assembly) C to T at 110808197 bp
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000141678 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000070565] [ENSMUST00000084974] [ENSMUST00000193053]
Predicted Effect noncoding transcript
Transcript: ENSMUST00000021701
Predicted Effect probably benign
Transcript: ENSMUST00000070565
SMART Domains Protein: ENSMUSP00000068904
Gene: ENSMUSG00000056458

S_TKc 4 285 6.78e-85 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000084974
SMART Domains Protein: ENSMUSP00000082041
Gene: ENSMUSG00000056458

Pfam:Pkinase_Tyr 1 138 8.4e-20 PFAM
Pfam:Pkinase 1 168 4.9e-36 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000193053
SMART Domains Protein: ENSMUSP00000141678
Gene: ENSMUSG00000037957

Blast:WD40 89 131 2e-16 BLAST
Predicted Effect noncoding transcript
Transcript: ENSMUST00000194118
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene belongs to the MAP kinase superfamily. The gene was found to be regulated by caudal type transcription factor 2 (Cdx2) protein. The encoded protein, which is localized to epithelial cells in the intestinal crypt, may play a role in growth arrest and differentiation of cells of upper crypt and lower villus regions. Multiple alternatively spliced transcript variants encoding different isoforms have been observed for this gene. [provided by RefSeq, Dec 2012]
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
C330021F23Rik A G 8: 3,583,904 T2A probably benign Het
Cc2d1b T G 4: 108,627,378 L470R probably damaging Het
Cd96 A T 16: 46,071,799 N275K possibly damaging Het
Col22a1 A G 15: 71,860,958 probably null Het
Cyb561 T C 11: 105,935,836 H197R probably damaging Het
Dlgap1 T C 17: 70,516,085 S22P probably benign Het
Dnajc6 A G 4: 101,508,089 probably benign Het
Fgf6 A T 6: 127,024,085 K185N possibly damaging Het
Fshr T C 17: 88,986,191 N353S probably damaging Het
Gabbr1 T A 17: 37,048,443 Y103* probably null Het
Gm7247 G A 14: 51,523,505 C177Y possibly damaging Het
Hikeshi A G 7: 89,935,781 F72L probably damaging Het
Ikzf4 T C 10: 128,634,547 E368G probably benign Het
Kdm3b A G 18: 34,809,409 E851G probably benign Het
Kif3b A G 2: 153,317,131 D284G probably damaging Het
Kyat3 G A 3: 142,734,474 A320T probably benign Het
Mrgpra3 A G 7: 47,589,519 F220L probably benign Het
Nr4a1 T C 15: 101,270,899 V272A probably damaging Het
Olfr1124 A G 2: 87,435,063 H192R probably benign Het
Olfr703 A G 7: 106,845,367 Y252C possibly damaging Het
Pikfyve T A 1: 65,260,121 probably null Het
Plekhn1 T G 4: 156,223,363 T369P probably damaging Het
Ptpn12 T C 5: 21,029,850 E45G probably damaging Het
Ralgps1 A T 2: 33,137,682 *516R probably null Het
Senp6 A G 9: 80,116,610 D385G probably damaging Het
Siglech T C 7: 55,772,591 probably benign Het
Slit1 A G 19: 41,650,835 L212P probably damaging Het
Smchd1 T A 17: 71,465,673 probably benign Het
Snapc4 A T 2: 26,369,312 C609S probably benign Het
Strn3 T C 12: 51,661,196 T139A possibly damaging Het
Tcaf3 T C 6: 42,593,385 T478A probably benign Het
Tlr3 A G 8: 45,400,690 S198P probably damaging Het
Ttn C T 2: 76,890,479 probably benign Het
Vil1 G A 1: 74,423,875 E406K probably damaging Het
Zfp462 A G 4: 55,011,483 probably null Het
Zfyve9 A G 4: 108,642,107 V1338A possibly damaging Het
Other mutations in Mok
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01925:Mok APN 12 110808212 missense probably benign 0.15
IGL02660:Mok APN 12 110828065 missense probably damaging 0.99
R0256:Mok UTSW 12 110808105 missense probably damaging 1.00
R1797:Mok UTSW 12 110808045 missense probably benign 0.28
R2022:Mok UTSW 12 110811823 missense probably benign 0.00
R2175:Mok UTSW 12 110815200 missense probably benign 0.01
R3840:Mok UTSW 12 110815157 missense probably benign 0.04
R3841:Mok UTSW 12 110815157 missense probably benign 0.04
R4645:Mok UTSW 12 110808439 unclassified probably benign
R5711:Mok UTSW 12 110808069 missense probably damaging 1.00
R6084:Mok UTSW 12 110814946 missense probably benign 0.01
R6336:Mok UTSW 12 110834124 critical splice donor site probably null
R6544:Mok UTSW 12 110810755 missense probably damaging 1.00
R7403:Mok UTSW 12 110815129 critical splice donor site probably null
R7557:Mok UTSW 12 110808399 missense probably benign
R7789:Mok UTSW 12 110811827 missense probably damaging 1.00
R8011:Mok UTSW 12 110814917 utr 3 prime probably benign
R8169:Mok UTSW 12 110808365 missense probably benign 0.00
R8487:Mok UTSW 12 110809907 critical splice donor site probably null
Posted On2011-07-12