Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL01719:Olfr739'

105018

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Olfr739

Ensembl Gene

ENSMUSG00000057903

Gene Name

olfactory receptor 739

Synonyms

MOR106-2, GA_x6K02T2PMLR-6121675-6122604

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.053) question?

Stock #

IGL01719

Quality Score

Status

Chromosome

Chromosomal Location

50418626-50427888 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 50424561 bp

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Serine at position 14 (F14S)

Ref Sequence

ENSEMBL: ENSMUSP00000150559 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000075261] [ENSMUST00000216949]

Predicted Effect

possibly damaging
Transcript: ENSMUST00000075261
AA Change: F14S

PolyPhen 2 Score 0.875 (Sensitivity: 0.83; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000074740
Gene: ENSMUSG00000057903
AA Change: F14S

Domain	Start	End	E-Value	Type
Pfam:7tm_4	33	309	1.1e-53	PFAM
Pfam:7tm_1	43	292	1.9e-22	PFAM

Predicted Effect

possibly damaging
Transcript: ENSMUST00000216949
AA Change: F14S

PolyPhen 2 Score 0.875 (Sensitivity: 0.83; Specificity: 0.93)

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 25 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Alms1	G	A	6: 85,628,094	R1773Q	probably benign	Het
Ankk1	A	G	9: 49,416,781	V366A	probably benign	Het
Antxr2	C	T	5: 97,948,273	R384Q	possibly damaging	Het
Cdh13	G	A	8: 118,675,188	V110M	probably benign	Het
Ctnna2	T	A	6: 77,636,975	K198*	probably null	Het
Dpf3	C	A	12: 83,294,433	S223I	probably damaging	Het
Galnt5	A	G	2: 57,998,543	R52G	probably damaging	Het
Gm4787	G	A	12: 81,377,174	R737C	possibly damaging	Het
Grin2b	T	A	6: 135,733,381	I1056F	probably damaging	Het
H2al2a	T	A	2: 17,996,635	H80L	probably damaging	Het
Hipk3	T	C	2: 104,437,089	H601R	possibly damaging	Het
Hivep2	T	C	10: 14,130,523	L955P	probably damaging	Het
Jund	C	T	8: 70,699,236	A60V	possibly damaging	Het
Klhdc7a	A	G	4: 139,966,550	L362P	probably damaging	Het
Lpar5	T	G	6: 125,082,006	V230G	possibly damaging	Het
Lrba	C	T	3: 86,327,596		probably benign	Het
Pcdhb5	T	G	18: 37,321,022	S152A	probably benign	Het
Plekha5	A	C	6: 140,570,129	E702D	probably damaging	Het
Ppt1	A	G	4: 122,844,067	Y66C	probably damaging	Het
S1pr5	C	A	9: 21,243,954	R392L	probably benign	Het
Slc37a2	T	C	9: 37,234,178	T410A	probably damaging	Het
St18	A	G	1: 6,845,796		probably benign	Het
Taar7d	T	A	10: 24,027,967	M249K	probably benign	Het
Vwa5b2	T	C	16: 20,597,433		probably null	Het
Zan	T	A	5: 137,395,654	T4512S	unknown	Het

Other mutations in Olfr739

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02430:Olfr739	APN	14	50425151	missense	probably benign
IGL02603:Olfr739	APN	14	50425200	missense	probably damaging	1.00
IGL02959:Olfr739	APN	14	50424932	missense	possibly damaging	0.76
IGL03154:Olfr739	APN	14	50424623	missense	probably benign	0.00
R0455:Olfr739	UTSW	14	50424902	missense	possibly damaging	0.45
R1984:Olfr739	UTSW	14	50425391	missense	possibly damaging	0.93
R3160:Olfr739	UTSW	14	50425031	missense	probably damaging	0.99
R3161:Olfr739	UTSW	14	50425031	missense	probably damaging	0.99
R3162:Olfr739	UTSW	14	50425031	missense	probably damaging	0.99
R4821:Olfr739	UTSW	14	50424749	missense	possibly damaging	0.96
R4880:Olfr739	UTSW	14	50425301	missense	possibly damaging	0.90
R5047:Olfr739	UTSW	14	50425239	missense	probably damaging	1.00
R5384:Olfr739	UTSW	14	50425389	missense	possibly damaging	0.77
R5385:Olfr739	UTSW	14	50425389	missense	possibly damaging	0.77
R5386:Olfr739	UTSW	14	50425389	missense	possibly damaging	0.77
R5640:Olfr739	UTSW	14	50424654	missense	probably benign	0.18
R5809:Olfr739	UTSW	14	50425448	makesense	probably null
R6035:Olfr739	UTSW	14	50424527	missense	probably benign
R6035:Olfr739	UTSW	14	50424527	missense	probably benign
R6229:Olfr739	UTSW	14	50425205	missense	probably benign	0.38
R6614:Olfr739	UTSW	14	50425089	missense	probably benign	0.00
R7308:Olfr739	UTSW	14	50425265	missense	possibly damaging	0.57
R7443:Olfr739	UTSW	14	50425050	missense	probably damaging	1.00
R7699:Olfr739	UTSW	14	50425335	missense	probably benign
R7700:Olfr739	UTSW	14	50425335	missense	probably benign
R7851:Olfr739	UTSW	14	50425370	missense	probably damaging	0.99
R8397:Olfr739	UTSW	14	50424680	missense	probably damaging	1.00

Posted On

2014-01-21