Incidental Mutation 'IGL01719:Lpar5'
ID105025
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Lpar5
Ensembl Gene ENSMUSG00000067714
Gene Namelysophosphatidic acid receptor 5
SynonymsLPA5, LOC381810, Gpr92, GPR93
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.116) question?
Stock #IGL01719
Quality Score
Status
Chromosome6
Chromosomal Location125067920-125082472 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to G at 125082006 bp
ZygosityHeterozygous
Amino Acid Change Valine to Glycine at position 230 (V230G)
Ref Sequence ENSEMBL: ENSMUSP00000132511 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000088292] [ENSMUST00000140346] [ENSMUST00000171989]
Predicted Effect possibly damaging
Transcript: ENSMUST00000088292
AA Change: V230G

PolyPhen 2 Score 0.937 (Sensitivity: 0.80; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000085630
Gene: ENSMUSG00000067714
AA Change: V230G

DomainStartEndE-ValueType
low complexity region 15 27 N/A INTRINSIC
Pfam:7tm_1 55 313 7.4e-40 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000140346
SMART Domains Protein: ENSMUSP00000119904
Gene: ENSMUSG00000067714

DomainStartEndE-ValueType
low complexity region 15 27 N/A INTRINSIC
Pfam:7tm_1 55 164 1.5e-30 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000171989
AA Change: V230G

PolyPhen 2 Score 0.937 (Sensitivity: 0.80; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000132511
Gene: ENSMUSG00000067714
AA Change: V230G

DomainStartEndE-ValueType
low complexity region 15 27 N/A INTRINSIC
Pfam:7tm_1 55 313 1.1e-48 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000203956
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the rhodopsin class of G protein-coupled transmembrane receptors. This protein transmits extracellular signals from lysophosphatidic acid to cells through heterotrimeric G proteins and mediates numerous cellular processes. Many G protein receptors serve as targets for pharmaceutical drugs. Transcript variants of this gene have been described.[provided by RefSeq, Dec 2008]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit resistance to neuropathic pain and myelin sheath alterations. Mice homozygous for a different targeted allele exhibit decreased nociception sensitivity, decreased anxiety-related response and enhanced coordination and spatial learning. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 25 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Alms1 G A 6: 85,628,094 R1773Q probably benign Het
Ankk1 A G 9: 49,416,781 V366A probably benign Het
Antxr2 C T 5: 97,948,273 R384Q possibly damaging Het
Cdh13 G A 8: 118,675,188 V110M probably benign Het
Ctnna2 T A 6: 77,636,975 K198* probably null Het
Dpf3 C A 12: 83,294,433 S223I probably damaging Het
Galnt5 A G 2: 57,998,543 R52G probably damaging Het
Gm4787 G A 12: 81,377,174 R737C possibly damaging Het
Grin2b T A 6: 135,733,381 I1056F probably damaging Het
H2al2a T A 2: 17,996,635 H80L probably damaging Het
Hipk3 T C 2: 104,437,089 H601R possibly damaging Het
Hivep2 T C 10: 14,130,523 L955P probably damaging Het
Jund C T 8: 70,699,236 A60V possibly damaging Het
Klhdc7a A G 4: 139,966,550 L362P probably damaging Het
Lrba C T 3: 86,327,596 probably benign Het
Olfr739 T C 14: 50,424,561 F14S possibly damaging Het
Pcdhb5 T G 18: 37,321,022 S152A probably benign Het
Plekha5 A C 6: 140,570,129 E702D probably damaging Het
Ppt1 A G 4: 122,844,067 Y66C probably damaging Het
S1pr5 C A 9: 21,243,954 R392L probably benign Het
Slc37a2 T C 9: 37,234,178 T410A probably damaging Het
St18 A G 1: 6,845,796 probably benign Het
Taar7d T A 10: 24,027,967 M249K probably benign Het
Vwa5b2 T C 16: 20,597,433 probably null Het
Zan T A 5: 137,395,654 T4512S unknown Het
Other mutations in Lpar5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01830:Lpar5 APN 6 125081822 missense probably benign 0.01
IGL01975:Lpar5 APN 6 125081787 missense probably damaging 0.99
IGL02021:Lpar5 APN 6 125081992 nonsense probably null
IGL02718:Lpar5 APN 6 125082244 missense probably damaging 1.00
IGL03027:Lpar5 APN 6 125082240 missense probably damaging 1.00
IGL03300:Lpar5 APN 6 125082240 missense probably damaging 1.00
F5770:Lpar5 UTSW 6 125081727 missense possibly damaging 0.88
R0633:Lpar5 UTSW 6 125081991 missense probably benign 0.25
R1639:Lpar5 UTSW 6 125081601 missense probably damaging 1.00
R1822:Lpar5 UTSW 6 125081415 missense possibly damaging 0.76
R2227:Lpar5 UTSW 6 125081135 critical splice acceptor site probably null
R4019:Lpar5 UTSW 6 125081675 missense probably damaging 1.00
R4288:Lpar5 UTSW 6 125081864 missense probably benign 0.00
R4705:Lpar5 UTSW 6 125082207 missense possibly damaging 0.64
R4787:Lpar5 UTSW 6 125082498 unclassified probably null
R5027:Lpar5 UTSW 6 125082147 missense possibly damaging 0.69
R6114:Lpar5 UTSW 6 125081676 missense probably damaging 1.00
R7197:Lpar5 UTSW 6 125082384 missense probably benign 0.00
R7779:Lpar5 UTSW 6 125082244 missense probably damaging 1.00
R8193:Lpar5 UTSW 6 125081339 missense probably benign
R8264:Lpar5 UTSW 6 125081502 missense probably damaging 1.00
V7580:Lpar5 UTSW 6 125081727 missense possibly damaging 0.88
V7581:Lpar5 UTSW 6 125081727 missense possibly damaging 0.88
V7582:Lpar5 UTSW 6 125081727 missense possibly damaging 0.88
Z1176:Lpar5 UTSW 6 125081379 missense possibly damaging 0.92
Z1176:Lpar5 UTSW 6 125082072 missense probably damaging 1.00
Z1177:Lpar5 UTSW 6 125082018 missense probably damaging 1.00
Posted On2014-01-21