Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01720:Lrrc15'

105060

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Lrrc15

Ensembl Gene

ENSMUSG00000052316

Gene Name

leucine rich repeat containing 15

Synonyms

5430427N11Rik

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL01720

Quality Score

Status

Chromosome

Chromosomal Location

30088120-30102072 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 30092138 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Lysine at position 400 (N400K)

Ref Sequence

ENSEMBL: ENSMUSP00000066777 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000064606]

AlphaFold

Q80X72

Predicted Effect

probably benign
Transcript: ENSMUST00000064606
AA Change: N400K

PolyPhen 2 Score 0.188 (Sensitivity: 0.92; Specificity: 0.87)

SMART Domains

Protein: ENSMUSP00000066777
Gene: ENSMUSG00000052316
AA Change: N400K

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
LRRNT	24	57	2.98e0	SMART
LRR	76	99	6.97e1	SMART
LRR_TYP	100	123	1.98e-4	SMART
LRR	124	147	4.08e0	SMART
LRR_TYP	148	171	2.4e-3	SMART
LRR_TYP	172	195	1.82e-3	SMART
LRR_TYP	196	219	1.18e-2	SMART
LRR_TYP	220	243	3.16e-3	SMART
LRR_TYP	245	267	3.39e-3	SMART
LRR_TYP	268	291	8.81e-2	SMART
LRR_TYP	292	315	9.5e-7	SMART
LRR_TYP	316	339	6.52e-5	SMART
LRR_TYP	340	363	7.78e-3	SMART
LRR_TYP	364	387	1.03e-2	SMART
LRR	388	411	8.48e0	SMART
LRRCT	423	474	1.11e-3	SMART
low complexity region	485	512	N/A	INTRINSIC
transmembrane domain	537	559	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 46 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Alms1	G	A	6: 85,605,076 (GRCm39)	R1773Q	probably benign	Het
Apc2	T	C	10: 80,150,333 (GRCm39)	S1796P	probably benign	Het
Asxl3	A	T	18: 22,658,382 (GRCm39)	I2131F	probably damaging	Het
Cdc42bpa	T	A	1: 179,938,847 (GRCm39)	D833E	probably damaging	Het
Cenpc1	A	G	5: 86,193,284 (GRCm39)	S202P	possibly damaging	Het
Cenpf	T	C	1: 189,414,583 (GRCm39)	E178G	probably benign	Het
Cenpf	T	C	1: 189,383,412 (GRCm39)	Y2636C	probably damaging	Het
Cfap251	A	G	5: 123,460,557 (GRCm39)	D1173G	probably benign	Het
Chkb	C	T	15: 89,312,155 (GRCm39)		probably null	Het
Cldn20	A	G	17: 3,583,375 (GRCm39)	T183A	probably benign	Het
Cpne8	C	T	15: 90,385,703 (GRCm39)	V442I	probably benign	Het
Cx3cl1	T	A	8: 95,504,701 (GRCm39)	M39K	probably damaging	Het
Dgkd	T	A	1: 87,864,487 (GRCm39)	L124Q	probably damaging	Het
Duxf4	A	C	10: 58,072,211 (GRCm39)	M1R	probably null	Het
Fam180a	T	C	6: 35,290,500 (GRCm39)	H161R	probably benign	Het
Galt	C	A	4: 41,757,463 (GRCm39)	R212S	probably damaging	Het
Gja10	T	C	4: 32,601,007 (GRCm39)	D459G	probably benign	Het
Glb1	T	C	9: 114,249,573 (GRCm39)		probably null	Het
Gm5709	A	T	3: 59,513,975 (GRCm39)		noncoding transcript	Het
Igf2r	A	G	17: 12,920,200 (GRCm39)	Y1380H	probably damaging	Het
Jag1	C	T	2: 136,929,023 (GRCm39)	G811D	probably damaging	Het
Lrguk	T	C	6: 34,020,412 (GRCm39)	F52S	probably damaging	Het
Map3k12	A	G	15: 102,410,621 (GRCm39)		probably benign	Het
Mbnl2	C	T	14: 120,562,682 (GRCm39)	T11I	probably damaging	Het
Mettl22	T	C	16: 8,302,117 (GRCm39)		probably benign	Het
Mgat4a	G	A	1: 37,483,979 (GRCm39)	A497V	probably damaging	Het
Mrpl49	C	A	19: 6,105,187 (GRCm39)	M91I	possibly damaging	Het
Or2ag18	A	T	7: 106,405,416 (GRCm39)	D84E	probably damaging	Het
Or2q1	G	A	6: 42,794,527 (GRCm39)	V41I	probably benign	Het
Pcdhb5	T	G	18: 37,454,075 (GRCm39)	S152A	probably benign	Het
Ppp1r13b	T	C	12: 111,824,694 (GRCm39)	T102A	probably benign	Het
Pramel23	T	A	4: 143,423,410 (GRCm39)		probably benign	Het
Prodh2	A	G	7: 30,210,628 (GRCm39)	D393G	probably damaging	Het
Pyroxd1	A	G	6: 142,296,784 (GRCm39)		probably benign	Het
Rad17	A	T	13: 100,759,366 (GRCm39)	C554S	possibly damaging	Het
Rapgef5	T	C	12: 117,577,055 (GRCm39)		probably benign	Het
Setdb2	A	G	14: 59,660,885 (GRCm39)	V86A	possibly damaging	Het
Slc38a2	A	T	15: 96,589,092 (GRCm39)		probably benign	Het
Slc9c1	A	G	16: 45,376,132 (GRCm39)	Y406C	probably damaging	Het
Slit1	T	C	19: 41,622,653 (GRCm39)	D702G	probably benign	Het
Stat3	T	C	11: 100,794,484 (GRCm39)	H275R	possibly damaging	Het
Susd5	T	A	9: 113,893,052 (GRCm39)	N43K	possibly damaging	Het
Ttc3	A	T	16: 94,186,228 (GRCm39)	K124N	probably damaging	Het
Usp36	C	A	11: 118,165,828 (GRCm39)	R165L	probably damaging	Het
Vwf	G	A	6: 125,619,798 (GRCm39)	R1492Q	possibly damaging	Het
Zbed6	A	G	1: 133,585,264 (GRCm39)	V691A	possibly damaging	Het

Other mutations in Lrrc15

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00495:Lrrc15	APN	16	30,092,848 (GRCm39)	missense	possibly damaging	0.90
R0138:Lrrc15	UTSW	16	30,092,267 (GRCm39)	missense	possibly damaging	0.63
R0317:Lrrc15	UTSW	16	30,092,561 (GRCm39)	missense	probably benign
R0497:Lrrc15	UTSW	16	30,091,710 (GRCm39)	missense	probably damaging	0.98
R0528:Lrrc15	UTSW	16	30,092,566 (GRCm39)	missense	probably damaging	0.99
R1122:Lrrc15	UTSW	16	30,092,719 (GRCm39)	missense	probably damaging	1.00
R1950:Lrrc15	UTSW	16	30,092,649 (GRCm39)	missense	probably benign	0.21
R2898:Lrrc15	UTSW	16	30,092,604 (GRCm39)	missense	probably benign	0.01
R4272:Lrrc15	UTSW	16	30,092,673 (GRCm39)	missense	probably benign	0.06
R4839:Lrrc15	UTSW	16	30,093,086 (GRCm39)	missense	probably benign	0.00
R5091:Lrrc15	UTSW	16	30,092,172 (GRCm39)	missense	probably damaging	1.00
R5369:Lrrc15	UTSW	16	30,091,722 (GRCm39)	missense	possibly damaging	0.93
R6076:Lrrc15	UTSW	16	30,091,806 (GRCm39)	missense	probably benign	0.25
R6133:Lrrc15	UTSW	16	30,093,054 (GRCm39)	missense	probably benign	0.11
R7017:Lrrc15	UTSW	16	30,091,780 (GRCm39)	missense	probably benign	0.00
R9217:Lrrc15	UTSW	16	30,092,415 (GRCm39)	missense	probably damaging	1.00
R9507:Lrrc15	UTSW	16	30,092,829 (GRCm39)	missense	probably damaging	1.00
R9533:Lrrc15	UTSW	16	30,092,637 (GRCm39)	missense	possibly damaging	0.67
R9562:Lrrc15	UTSW	16	30,093,016 (GRCm39)	missense	probably damaging	1.00
R9565:Lrrc15	UTSW	16	30,093,016 (GRCm39)	missense	probably damaging	1.00
R9616:Lrrc15	UTSW	16	30,092,517 (GRCm39)	missense	probably damaging	1.00
R9641:Lrrc15	UTSW	16	30,093,006 (GRCm39)	missense	probably damaging	1.00
R9755:Lrrc15	UTSW	16	30,093,147 (GRCm39)	missense	possibly damaging	0.95
Z1176:Lrrc15	UTSW	16	30,093,070 (GRCm39)	missense	probably benign	0.31

Posted On

2014-01-21