Incidental Mutation 'IGL01721:Krtap26-1'
ID105122
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Krtap26-1
Ensembl Gene ENSMUSG00000071471
Gene Namekeratin associated protein 26-1
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.064) question?
Stock #IGL01721
Quality Score
Status
Chromosome16
Chromosomal Location88646824-88647796 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to A at 88647172 bp
ZygosityHeterozygous
Amino Acid Change Proline to Leucine at position 187 (P187L)
Ref Sequence ENSEMBL: ENSMUSP00000093626 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000095934]
Predicted Effect probably damaging
Transcript: ENSMUST00000095934
AA Change: P187L

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000093626
Gene: ENSMUSG00000071471
AA Change: P187L

DomainStartEndE-ValueType
Pfam:PMG 4 213 2.9e-65 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700088E04Rik T C 15: 79,139,253 M51V possibly damaging Het
Acad8 A G 9: 26,992,267 probably benign Het
Atp2a2 A G 5: 122,500,792 V53A possibly damaging Het
Bicra T C 7: 15,988,699 T298A probably benign Het
Ccdc185 C T 1: 182,748,978 E49K possibly damaging Het
Cfhr2 A G 1: 139,813,614 S208P probably benign Het
Chd1 T C 17: 15,770,168 Y1661H probably damaging Het
Cntnap5a A G 1: 116,157,637 H435R probably benign Het
Cog8 A G 8: 107,054,065 V187A probably benign Het
Col24a1 A G 3: 145,538,567 H1532R probably benign Het
Dpp6 A G 5: 27,631,520 Y336C probably damaging Het
Drosha T A 15: 12,846,112 Y444* probably null Het
Egf A T 3: 129,697,722 C374* probably null Het
Eif2b3 C T 4: 117,058,804 H203Y probably damaging Het
Erbb4 A G 1: 68,254,563 V723A possibly damaging Het
Fbxo21 T C 5: 117,988,790 I202T probably benign Het
Gbp6 T C 5: 105,274,207 M544V probably benign Het
Gm10750 T C 2: 149,016,044 T96A unknown Het
Gm1840 A T 8: 5,639,896 noncoding transcript Het
Gm8232 A T 14: 44,437,183 probably null Het
Gsdma3 T C 11: 98,637,956 V412A possibly damaging Het
Hs6st1 A T 1: 36,068,935 H93L probably damaging Het
Hsf2 G A 10: 57,496,181 E77K probably benign Het
Ing3 T A 6: 21,968,880 probably benign Het
Ints6 T C 14: 62,713,739 I280M probably damaging Het
Kazn C A 4: 142,159,043 probably null Het
Klhl20 T C 1: 161,095,587 Y13C probably damaging Het
Mga T A 2: 119,935,239 I1329K probably damaging Het
Mindy4 A G 6: 55,223,999 D223G probably damaging Het
Ncor2 T C 5: 125,050,937 E124G probably damaging Het
Nfat5 G A 8: 107,344,979 probably null Het
Nkain1 A G 4: 130,532,134 F184L probably benign Het
Olfr1061 T C 2: 86,413,333 T240A probably damaging Het
Rars A T 11: 35,828,664 F110L probably damaging Het
Rfx6 A C 10: 51,723,077 K509N probably damaging Het
Serpinb2 T C 1: 107,515,603 L44P probably damaging Het
Sin3a G A 9: 57,095,325 R167Q probably damaging Het
Sos2 T A 12: 69,603,867 T809S probably damaging Het
Stard9 A G 2: 120,703,330 E3356G probably damaging Het
Vmn1r52 A G 6: 90,178,923 T70A probably benign Het
Other mutations in Krtap26-1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00886:Krtap26-1 APN 16 88647379 missense possibly damaging 0.62
IGL01963:Krtap26-1 APN 16 88647668 missense probably damaging 1.00
IGL02524:Krtap26-1 APN 16 88647479 missense possibly damaging 0.70
R0383:Krtap26-1 UTSW 16 88647243 nonsense probably null
R2367:Krtap26-1 UTSW 16 88647325 missense probably benign 0.28
R4694:Krtap26-1 UTSW 16 88647220 missense possibly damaging 0.70
R6699:Krtap26-1 UTSW 16 88647715 missense unknown
R6884:Krtap26-1 UTSW 16 88647579 missense probably damaging 1.00
R7299:Krtap26-1 UTSW 16 88647244 missense possibly damaging 0.49
R7808:Krtap26-1 UTSW 16 88647310 missense not run
Posted On2014-01-21