Incidental Mutation 'IGL01722:Apol11a'
ID105146
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Apol11a
Ensembl Gene ENSMUSG00000091650
Gene Nameapolipoprotein L 11a
SynonymsEG626615
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.053) question?
Stock #IGL01722
Quality Score
Status
Chromosome15
Chromosomal Location77508271-77518051 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 77517107 bp
ZygosityHeterozygous
Amino Acid Change Methionine to Leucine at position 265 (M265L)
Ref Sequence ENSEMBL: ENSMUSP00000132565 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000172191]
Predicted Effect probably benign
Transcript: ENSMUST00000172191
AA Change: M265L

PolyPhen 2 Score 0.032 (Sensitivity: 0.95; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000132565
Gene: ENSMUSG00000091650
AA Change: M265L

DomainStartEndE-ValueType
Pfam:ApoL 28 328 1e-90 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 29 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acvr1c T A 2: 58,283,549 probably benign Het
Alb G A 5: 90,470,839 probably null Het
Ankrd9 A G 12: 110,977,363 V46A probably damaging Het
Ccdc158 T C 5: 92,662,739 N97D possibly damaging Het
Cobl T G 11: 12,253,987 H823P probably benign Het
Dnaja2 A T 8: 85,553,279 H90Q probably benign Het
Dpagt1 T C 9: 44,327,602 F73S possibly damaging Het
Dph3 C T 14: 32,085,460 E20K possibly damaging Het
Fam198a G A 9: 121,965,083 S101N possibly damaging Het
Fbxl13 G T 5: 21,490,414 T660K possibly damaging Het
Glt6d1 T C 2: 25,794,419 T192A probably benign Het
Mroh7 C T 4: 106,703,161 V649I probably benign Het
Mta3 T C 17: 83,755,643 Y4H possibly damaging Het
Myh14 A G 7: 44,643,532 L369P probably damaging Het
Olfr1263 T C 2: 90,015,007 C26R probably benign Het
Olfr1385 G T 11: 49,494,966 L144F probably damaging Het
Paxx T C 2: 25,460,265 D110G probably damaging Het
Pcyox1 T G 6: 86,388,753 D493A probably damaging Het
Plk2 A G 13: 110,399,442 E560G probably benign Het
Rnf6 A G 5: 146,210,226 F661L probably benign Het
Sema4a T C 3: 88,438,184 K531E probably benign Het
Svs2 T C 2: 164,237,526 K154E possibly damaging Het
Tbx4 A T 11: 85,911,943 Q242L probably damaging Het
Tgm3 A T 2: 130,044,568 I570F probably damaging Het
Thrap3 A T 4: 126,165,529 M908K possibly damaging Het
Trmo A G 4: 46,386,092 probably null Het
Usp8 T A 2: 126,758,152 L997Q probably damaging Het
Vmn1r202 T C 13: 22,501,720 R176G probably benign Het
Vps52 T A 17: 33,961,615 Y308* probably null Het
Other mutations in Apol11a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03112:Apol11a APN 15 77517309 missense probably damaging 0.99
R1296:Apol11a UTSW 15 77511019 splice site probably benign
R1576:Apol11a UTSW 15 77516931 missense probably damaging 1.00
R1875:Apol11a UTSW 15 77513566 missense possibly damaging 0.81
R2517:Apol11a UTSW 15 77517195 missense probably benign 0.00
R4614:Apol11a UTSW 15 77516572 missense probably benign 0.08
R4892:Apol11a UTSW 15 77516990 nonsense probably null
R5027:Apol11a UTSW 15 77516953 missense probably damaging 1.00
R5334:Apol11a UTSW 15 77516753 missense probably benign 0.14
R6208:Apol11a UTSW 15 77517041 missense probably damaging 0.99
R7883:Apol11a UTSW 15 77516574 missense probably damaging 1.00
Posted On2014-01-21