Incidental Mutation 'IGL01723:Olfr1110'
ID105165
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr1110
Ensembl Gene ENSMUSG00000075159
Gene Nameolfactory receptor 1110
SynonymsGA_x6K02T2Q125-48621299-48620361, MOR172-4
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.083) question?
Stock #IGL01723
Quality Score
Status
Chromosome2
Chromosomal Location87133673-87140300 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 87135478 bp
ZygosityHeterozygous
Amino Acid Change Valine to Alanine at position 281 (V281A)
Ref Sequence ENSEMBL: ENSMUSP00000149495 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099861] [ENSMUST00000152758]
Predicted Effect probably benign
Transcript: ENSMUST00000099861
AA Change: V281A

PolyPhen 2 Score 0.014 (Sensitivity: 0.96; Specificity: 0.79)
SMART Domains Protein: ENSMUSP00000097447
Gene: ENSMUSG00000075159
AA Change: V281A

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 3.1e-53 PFAM
Pfam:7tm_1 41 290 1.4e-20 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000152758
AA Change: V281A

PolyPhen 2 Score 0.014 (Sensitivity: 0.96; Specificity: 0.79)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca12 G A 1: 71,314,168 A705V probably benign Het
Abcc10 A T 17: 46,313,745 C728S probably damaging Het
Alms1 G A 6: 85,628,094 R1773Q probably benign Het
BC067074 A T 13: 113,367,557 Q198L possibly damaging Het
C030048H21Rik A G 2: 26,254,768 S1316P possibly damaging Het
Cd86 A G 16: 36,607,124 L281S probably benign Het
Cdon C T 9: 35,503,338 P1170S probably benign Het
Col11a2 T A 17: 34,061,280 probably benign Het
Cyp2j12 A G 4: 96,102,126 V401A possibly damaging Het
Cyp7a1 A T 4: 6,272,442 I257N probably damaging Het
Ddhd2 A T 8: 25,735,011 L593* probably null Het
Dnah8 T C 17: 30,708,471 L1367S probably damaging Het
Dsg4 G A 18: 20,466,510 V728M probably damaging Het
Dsp G A 13: 38,179,084 V447M probably damaging Het
Epx C T 11: 87,869,402 R462H probably damaging Het
Fgf18 T C 11: 33,134,332 T41A probably damaging Het
Fh1 G T 1: 175,601,542 A469D probably damaging Het
Hcn1 A C 13: 117,976,055 S852R probably damaging Het
Hmcn1 A T 1: 150,744,960 S1166R probably benign Het
Krt78 C T 15: 101,951,798 G228S possibly damaging Het
Lrrn4 T C 2: 132,870,061 E614G possibly damaging Het
Mettl9 T C 7: 121,052,269 I180T possibly damaging Het
Mgat2 A G 12: 69,185,641 T330A probably damaging Het
Myh13 T C 11: 67,369,219 probably benign Het
Nipbl G A 15: 8,335,071 T1283I possibly damaging Het
Nxpe4 A G 9: 48,398,598 D387G probably benign Het
Olfr382 T A 11: 73,516,626 D191V probably damaging Het
Pcdhb5 T G 18: 37,321,022 S152A probably benign Het
Pcnt C T 10: 76,418,499 R832H possibly damaging Het
Ptprd A C 4: 76,243,673 S108R probably damaging Het
Ryr3 C T 2: 112,650,111 probably null Het
Slc22a4 C T 11: 53,988,845 V463M probably benign Het
Soga1 T C 2: 157,030,614 M938V probably benign Het
Ttn A T 2: 76,730,404 L29218I probably damaging Het
Ttn T A 2: 76,730,402 L29218F probably damaging Het
Vmn2r44 T A 7: 8,377,916 H326L probably damaging Het
Vps13d A T 4: 145,173,145 M188K possibly damaging Het
Other mutations in Olfr1110
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01447:Olfr1110 APN 2 87135999 nonsense probably null
IGL01887:Olfr1110 APN 2 87135541 missense possibly damaging 0.89
IGL01903:Olfr1110 APN 2 87135379 splice site probably null
IGL02214:Olfr1110 APN 2 87135505 missense probably damaging 1.00
R0990:Olfr1110 UTSW 2 87135742 missense possibly damaging 0.69
R1933:Olfr1110 UTSW 2 87135844 missense probably damaging 1.00
R2226:Olfr1110 UTSW 2 87136246 missense possibly damaging 0.87
R3770:Olfr1110 UTSW 2 87135814 missense probably damaging 1.00
R4459:Olfr1110 UTSW 2 87135661 missense probably benign 0.00
R4461:Olfr1110 UTSW 2 87135661 missense probably benign 0.00
R4780:Olfr1110 UTSW 2 87135877 missense probably damaging 0.99
R5105:Olfr1110 UTSW 2 87136210 missense probably benign 0.01
R5995:Olfr1110 UTSW 2 87135856 missense probably damaging 1.00
R8177:Olfr1110 UTSW 2 87135950 missense possibly damaging 0.92
Z1177:Olfr1110 UTSW 2 87136297 missense probably benign 0.00
Posted On2014-01-21