Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01728:Agbl3'

105362

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Agbl3

Ensembl Gene

ENSMUSG00000038836

Gene Name

ATP/GTP binding protein-like 3

Synonyms

4930431N21Rik, 2900053G10Rik, 6530406M24Rik

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL01728

Quality Score

Status

Chromosome

Chromosomal Location

34780432-34859459 bp(+) (GRCm38)

Type of Mutation

start codon destroyed

DNA Base Change (assembly)

T to C at 34782157 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Threonine at position 1 (M1T)

Ref Sequence

ENSEMBL: ENSMUSP00000116066 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000115009] [ENSMUST00000115012] [ENSMUST00000115014] [ENSMUST00000115016] [ENSMUST00000115017] [ENSMUST00000135304] [ENSMUST00000148834]

AlphaFold

Q8CDP0

Predicted Effect

probably null
Transcript: ENSMUST00000115009
AA Change: M1T

Predicted Effect

probably null
Transcript: ENSMUST00000115012
AA Change: M1T

Predicted Effect

probably null
Transcript: ENSMUST00000115014
AA Change: M1T

SMART Domains

Protein: ENSMUSP00000110666
Gene: ENSMUSG00000038836
AA Change: M1T

Domain	Start	End	E-Value	Type
low complexity region	2	25	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000115016
AA Change: M1T

SMART Domains

Protein: ENSMUSP00000110668
Gene: ENSMUSG00000038836
AA Change: M1T

Domain	Start	End	E-Value	Type
low complexity region	2	25	N/A	INTRINSIC
Pfam:Peptidase_M14	314	563	2.7e-19	PFAM
low complexity region	614	629	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000115017
AA Change: M1T

SMART Domains

Protein: ENSMUSP00000110669
Gene: ENSMUSG00000038836
AA Change: M1T

Domain	Start	End	E-Value	Type
low complexity region	2	25	N/A	INTRINSIC
Pfam:Peptidase_M14	309	560	1e-33	PFAM
low complexity region	609	624	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000119745

Predicted Effect

probably null
Transcript: ENSMUST00000135304
AA Change: M1T

SMART Domains

Protein: ENSMUSP00000118303
Gene: ENSMUSG00000038836
AA Change: M1T

Domain	Start	End	E-Value	Type
low complexity region	2	25	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000143474

Predicted Effect

probably null
Transcript: ENSMUST00000148834
AA Change: M1T

SMART Domains

Protein: ENSMUSP00000116066
Gene: ENSMUSG00000038836
AA Change: M1T

Domain	Start	End	E-Value	Type
low complexity region	2	25	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000155726

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000155890

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000202017

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Homozygous mice for a targeted allele are viable and fertile. Mice homozygous for a knock-out allele exhibit normal response to herpes simplex virus (HSV) and vaccinia virus (VACV) infection. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 34 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700019A02Rik	A	G	1: 53,182,509	S54P	probably benign	Het
Adamtsl1	T	C	4: 86,110,837	I71T	probably damaging	Het
Ankib1	A	G	5: 3,701,992		probably benign	Het
Brinp3	T	G	1: 146,831,551		probably null	Het
Chuk	T	C	19: 44,098,646	N138S	possibly damaging	Het
Dock7	G	A	4: 98,962,331	T1588M	probably damaging	Het
Ehbp1	G	A	11: 22,101,115	T479I	probably damaging	Het
Gpn2	T	C	4: 133,584,502	I15T	possibly damaging	Het
Haao	A	G	17: 83,835,229	F149S	probably damaging	Het
Hist1h3b	G	A	13: 23,752,729	R117H	probably benign	Het
Iqsec3	T	A	6: 121,412,664		probably benign	Het
Lrrc39	G	T	3: 116,579,500		probably benign	Het
Ltbp2	C	A	12: 84,791,009	S1199I	probably damaging	Het
Mageb3	G	T	2: 121,954,460	P254T	probably damaging	Het
Mapkbp1	C	T	2: 120,023,821	P1300S	probably damaging	Het
Mtfmt	T	A	9: 65,435,818	L2H	probably damaging	Het
Myo18a	G	T	11: 77,777,856	G181W	probably damaging	Het
Mzf1	T	C	7: 13,051,727		probably benign	Het
Nfatc2	A	T	2: 168,536,242	L280Q	probably damaging	Het
Nudt15	A	G	14: 73,523,296		probably null	Het
Olfr633	T	C	7: 103,946,752	F62S	probably damaging	Het
Olfr920	A	G	9: 38,756,095	M136V	possibly damaging	Het
Parp14	A	G	16: 35,857,435	V721A	probably damaging	Het
Pbp2	G	T	6: 135,310,075	N91K	probably damaging	Het
Pde7b	C	A	10: 20,434,464		probably null	Het
Pramel7	C	A	2: 87,491,330	E120D	possibly damaging	Het
Rbbp5	C	T	1: 132,498,080	T516M	probably benign	Het
Slc16a12	A	G	19: 34,690,671	V28A	possibly damaging	Het
Slc6a9	T	C	4: 117,864,605	F276S	probably damaging	Het
Spata9	A	T	13: 75,993,074	I147L	probably benign	Het
Tenm4	A	T	7: 96,896,064	Y2429F	probably damaging	Het
Tmtc1	A	G	6: 148,411,066	S212P	probably benign	Het
Unc5cl	A	T	17: 48,459,963	I122F	probably damaging	Het
Unc79	T	A	12: 103,165,684	F2350I	probably damaging	Het

Other mutations in Agbl3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00336:Agbl3	APN	6	34846836	missense	probably damaging	1.00
IGL00835:Agbl3	APN	6	34799732	missense	probably damaging	1.00
IGL00840:Agbl3	APN	6	34799159	missense	possibly damaging	0.95
IGL01090:Agbl3	APN	6	34799887	missense	probably benign	0.40
IGL01123:Agbl3	APN	6	34846976	nonsense	probably null
IGL01707:Agbl3	APN	6	34839454	missense	possibly damaging	0.78
IGL02335:Agbl3	APN	6	34799750	missense	probably damaging	1.00
IGL02420:Agbl3	APN	6	34785307	missense	possibly damaging	0.47
IGL02551:Agbl3	APN	6	34823071	missense	possibly damaging	0.88
IGL02974:Agbl3	APN	6	34799822	missense	probably damaging	1.00
IGL03167:Agbl3	APN	6	34857659	missense	possibly damaging	0.92
IGL03182:Agbl3	APN	6	34803500	missense	probably damaging	1.00
R0044:Agbl3	UTSW	6	34799899	missense	probably damaging	1.00
R0499:Agbl3	UTSW	6	34839335	missense	probably benign
R0639:Agbl3	UTSW	6	34799705	missense	probably damaging	1.00
R0850:Agbl3	UTSW	6	34799204	missense	probably damaging	1.00
R1004:Agbl3	UTSW	6	34803451	missense	probably damaging	0.99
R1080:Agbl3	UTSW	6	34828235	missense	probably benign	0.14
R1589:Agbl3	UTSW	6	34857517	missense	possibly damaging	0.77
R2361:Agbl3	UTSW	6	34832505	missense	possibly damaging	0.87
R2495:Agbl3	UTSW	6	34846764	missense	probably damaging	1.00
R3236:Agbl3	UTSW	6	34823087	splice site	probably null
R3237:Agbl3	UTSW	6	34823087	splice site	probably null
R3420:Agbl3	UTSW	6	34793965	missense	probably benign	0.36
R3421:Agbl3	UTSW	6	34793965	missense	probably benign	0.36
R3422:Agbl3	UTSW	6	34793965	missense	probably benign	0.36
R3810:Agbl3	UTSW	6	34799729	missense	probably damaging	1.00
R3811:Agbl3	UTSW	6	34799729	missense	probably damaging	1.00
R4059:Agbl3	UTSW	6	34846899	missense	probably damaging	1.00
R4499:Agbl3	UTSW	6	34857598	missense	probably benign	0.00
R4687:Agbl3	UTSW	6	34798326	missense	probably damaging	1.00
R4854:Agbl3	UTSW	6	34785284	missense	probably damaging	0.97
R5354:Agbl3	UTSW	6	34814752	missense	probably benign	0.03
R5386:Agbl3	UTSW	6	34799196	missense	probably damaging	1.00
R5897:Agbl3	UTSW	6	34803573	missense	probably benign	0.21
R6018:Agbl3	UTSW	6	34799255	missense	probably damaging	1.00
R6148:Agbl3	UTSW	6	34857753	missense	possibly damaging	0.87
R6305:Agbl3	UTSW	6	34782210	missense	unknown
R6525:Agbl3	UTSW	6	34803594	nonsense	probably null
R6546:Agbl3	UTSW	6	34799299	missense	probably damaging	1.00
R6743:Agbl3	UTSW	6	34846953	missense	probably benign	0.03
R6986:Agbl3	UTSW	6	34839452	missense	probably benign	0.42
R7023:Agbl3	UTSW	6	34814769	missense	probably benign	0.02
R7411:Agbl3	UTSW	6	34814819	missense	probably damaging	0.99
R7469:Agbl3	UTSW	6	34814414	missense	probably damaging	1.00
R7631:Agbl3	UTSW	6	34857671	missense	possibly damaging	0.95
R7658:Agbl3	UTSW	6	34832508	missense	probably benign	0.11
R7743:Agbl3	UTSW	6	34846830	missense	probably damaging	1.00
R7801:Agbl3	UTSW	6	34839365	missense	probably benign	0.00
R8033:Agbl3	UTSW	6	34839494	missense	possibly damaging	0.95
R8203:Agbl3	UTSW	6	34799479	missense	probably damaging	1.00
R8769:Agbl3	UTSW	6	34857614	missense	probably damaging	0.96
R9072:Agbl3	UTSW	6	34799452	missense	probably damaging	1.00
R9073:Agbl3	UTSW	6	34799452	missense	probably damaging	1.00
R9210:Agbl3	UTSW	6	34798242	missense	probably damaging	0.98
R9255:Agbl3	UTSW	6	34812905	missense	probably damaging	1.00
R9536:Agbl3	UTSW	6	34846926	missense	probably benign
R9560:Agbl3	UTSW	6	34846908	missense	possibly damaging	0.94
R9662:Agbl3	UTSW	6	34832533	nonsense	probably null
RF014:Agbl3	UTSW	6	34799358	missense	possibly damaging	0.53
Z1177:Agbl3	UTSW	6	34799408	missense	probably damaging	1.00

Posted On

2014-01-21