Incidental Mutation 'IGL01729:Ear2'
ID 105384
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ear2
Ensembl Gene ENSMUSG00000072596
Gene Name eosinophil-associated, ribonuclease A family, member 2
Synonyms Rnase2, eosinophil-derived neurotoxin, liver
Accession Numbers
Essential gene? Probably non essential (E-score: 0.054) question?
Stock # IGL01729
Quality Score
Status
Chromosome 14
Chromosomal Location 44340111-44340988 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) A to T at 44340701 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Stop codon at position 120 (R120*)
Ref Sequence ENSEMBL: ENSMUSP00000074386 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074839]
AlphaFold P97425
Predicted Effect probably null
Transcript: ENSMUST00000074839
AA Change: R120*
SMART Domains Protein: ENSMUSP00000074386
Gene: ENSMUSG00000072596
AA Change: R120*

DomainStartEndE-ValueType
low complexity region 5 26 N/A INTRINSIC
RNAse_Pc 27 156 1.09e-57 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000226587
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A4galt A G 15: 83,112,526 (GRCm39) F86L probably damaging Het
Acer3 A G 7: 97,866,072 (GRCm39) V217A probably benign Het
Adcy10 T C 1: 165,340,737 (GRCm39) probably null Het
Adcy8 C T 15: 64,678,511 (GRCm39) V481I probably damaging Het
Ano3 C T 2: 110,611,739 (GRCm39) probably null Het
Arhgap23 C T 11: 97,344,787 (GRCm39) T583I probably damaging Het
Atp2a1 A G 7: 126,057,106 (GRCm39) L173P probably damaging Het
Clgn T C 8: 84,124,279 (GRCm39) W74R probably damaging Het
Clstn3 T C 6: 124,426,753 (GRCm39) S523G probably benign Het
Dnah10 A C 5: 124,864,529 (GRCm39) K2245Q probably benign Het
Dsg1b G T 18: 20,538,295 (GRCm39) V634L possibly damaging Het
Dzip3 A T 16: 48,748,726 (GRCm39) V864E possibly damaging Het
Fam171b T C 2: 83,685,881 (GRCm39) probably benign Het
Fam186b G A 15: 99,178,132 (GRCm39) S398L probably benign Het
Gabrp T C 11: 33,502,689 (GRCm39) K392E probably damaging Het
Gm10355 G A 3: 101,213,999 (GRCm39) noncoding transcript Het
Gm3424 T C 14: 17,337,188 (GRCm39) Y90C probably damaging Het
Gm8165 A G 14: 43,910,186 (GRCm39) V212A unknown Het
Grm7 G A 6: 111,223,145 (GRCm39) R395Q probably benign Het
Il1r1 T A 1: 40,333,986 (GRCm39) N185K probably damaging Het
Jam3 A G 9: 27,016,821 (GRCm39) F80L probably damaging Het
Map1s T C 8: 71,365,712 (GRCm39) Y206H probably damaging Het
Mroh7 A G 4: 106,561,402 (GRCm39) Y614H possibly damaging Het
Ntmt2 T A 1: 163,552,572 (GRCm39) D18V probably damaging Het
Pate2 T C 9: 35,581,888 (GRCm39) Y61H probably damaging Het
Prox1 T A 1: 189,893,372 (GRCm39) T358S probably benign Het
Prpf6 T A 2: 181,296,710 (GRCm39) D876E probably damaging Het
Rpf1 G A 3: 146,212,904 (GRCm39) R311C probably damaging Het
Rpusd2 T A 2: 118,865,837 (GRCm39) V178D probably damaging Het
Stx2 A G 5: 129,068,042 (GRCm39) F222L probably benign Het
Themis T A 10: 28,637,587 (GRCm39) Y230* probably null Het
Tmem132e T C 11: 82,325,942 (GRCm39) L314P possibly damaging Het
Tmtc3 T C 10: 100,283,017 (GRCm39) E846G probably benign Het
Trem1 T C 17: 48,551,603 (GRCm39) V88A possibly damaging Het
Trim21 G A 7: 102,213,100 (GRCm39) A66V probably damaging Het
Trip4 A C 9: 65,782,174 (GRCm39) V186G probably benign Het
Vps9d1 T C 8: 123,973,739 (GRCm39) E348G probably damaging Het
Xrn2 T C 2: 146,878,717 (GRCm39) probably null Het
Zfp36 A G 7: 28,077,888 (GRCm39) S7P probably damaging Het
Other mutations in Ear2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01700:Ear2 APN 14 44,340,716 (GRCm39) nonsense probably null
R0346:Ear2 UTSW 14 44,340,363 (GRCm39) missense probably damaging 1.00
R0458:Ear2 UTSW 14 44,340,705 (GRCm39) missense probably damaging 1.00
R1035:Ear2 UTSW 14 44,340,344 (GRCm39) start codon destroyed possibly damaging 0.59
R4920:Ear2 UTSW 14 44,340,582 (GRCm39) missense probably damaging 0.97
R5845:Ear2 UTSW 14 44,340,618 (GRCm39) missense probably benign 0.00
R6008:Ear2 UTSW 14 44,340,546 (GRCm39) missense probably damaging 1.00
R6432:Ear2 UTSW 14 44,340,660 (GRCm39) missense probably damaging 1.00
R6720:Ear2 UTSW 14 44,340,416 (GRCm39) missense probably damaging 0.99
R7721:Ear2 UTSW 14 44,340,495 (GRCm39) missense probably damaging 1.00
R8251:Ear2 UTSW 14 44,340,477 (GRCm39) missense probably benign 0.00
R8719:Ear2 UTSW 14 44,340,734 (GRCm39) missense possibly damaging 0.94
R9659:Ear2 UTSW 14 44,340,705 (GRCm39) missense probably damaging 1.00
R9776:Ear2 UTSW 14 44,340,729 (GRCm39) missense probably benign 0.02
R9788:Ear2 UTSW 14 44,340,705 (GRCm39) missense probably damaging 1.00
Posted On 2014-01-21