Incidental Mutation 'IGL01730:Tmem135'
ID 105443
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tmem135
Ensembl Gene ENSMUSG00000039428
Gene Name transmembrane protein 135
Synonyms 2810439K08Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.127) question?
Stock # IGL01730
Quality Score
Status
Chromosome 7
Chromosomal Location 88788922-89053430 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 88797252 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Isoleucine at position 335 (F335I)
Ref Sequence ENSEMBL: ENSMUSP00000114097 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000041968] [ENSMUST00000117852]
AlphaFold Q9CYV5
Predicted Effect possibly damaging
Transcript: ENSMUST00000041968
AA Change: F335I

PolyPhen 2 Score 0.721 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000042783
Gene: ENSMUSG00000039428
AA Change: F335I

DomainStartEndE-ValueType
Pfam:TMEM135_C_rich 9 142 2.2e-84 PFAM
transmembrane domain 147 169 N/A INTRINSIC
Pfam:Tim17 249 370 1.1e-9 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000117852
AA Change: F335I

PolyPhen 2 Score 0.821 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000114097
Gene: ENSMUSG00000039428
AA Change: F335I

DomainStartEndE-ValueType
low complexity region 52 65 N/A INTRINSIC
transmembrane domain 67 89 N/A INTRINSIC
transmembrane domain 96 115 N/A INTRINSIC
transmembrane domain 147 169 N/A INTRINSIC
transmembrane domain 299 321 N/A INTRINSIC
transmembrane domain 331 353 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000156153
Predicted Effect noncoding transcript
Transcript: ENSMUST00000207335
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Afap1 A G 5: 36,119,583 (GRCm39) E287G probably damaging Het
Bhmt A T 13: 93,761,917 (GRCm39) V122E probably damaging Het
Camta1 A G 4: 151,147,302 (GRCm39) I585T probably damaging Het
Cfap221 A G 1: 119,861,841 (GRCm39) S645P probably benign Het
Derl1 A T 15: 57,755,543 (GRCm39) F50Y possibly damaging Het
Dhrs3 T C 4: 144,646,042 (GRCm39) S117P probably damaging Het
E2f8 A T 7: 48,527,682 (GRCm39) probably benign Het
Fbn1 A T 2: 125,154,894 (GRCm39) probably benign Het
Fbxo15 A G 18: 84,982,299 (GRCm39) I250M probably benign Het
Ghr A T 15: 3,350,066 (GRCm39) S371T probably damaging Het
Gm5884 A T 6: 128,622,669 (GRCm39) noncoding transcript Het
Grhl2 T C 15: 37,338,018 (GRCm39) V496A probably benign Het
Gsap A G 5: 21,495,152 (GRCm39) probably benign Het
Irak3 T C 10: 120,014,005 (GRCm39) D148G probably benign Het
Itga2 A T 13: 114,990,947 (GRCm39) probably benign Het
Kif13b T C 14: 64,987,810 (GRCm39) probably null Het
Kif20b A T 19: 34,927,923 (GRCm39) K1022* probably null Het
Klhl17 G T 4: 156,316,157 (GRCm39) S399* probably null Het
Lcp2 A T 11: 34,000,943 (GRCm39) D42V possibly damaging Het
Lin7c G T 2: 109,726,785 (GRCm39) G145* probably null Het
Lrba A G 3: 86,648,731 (GRCm39) D2493G possibly damaging Het
Mobp A G 9: 119,996,992 (GRCm39) D41G probably damaging Het
Mycbp2 G A 14: 103,372,640 (GRCm39) Q785* probably null Het
Myl6b T C 10: 128,332,211 (GRCm39) Y85C possibly damaging Het
Nup133 G T 8: 124,664,972 (GRCm39) H240N probably benign Het
Or5b12 A C 19: 12,896,926 (GRCm39) F249C probably damaging Het
Plk4 T C 3: 40,760,285 (GRCm39) S394P probably benign Het
Prepl A G 17: 85,388,603 (GRCm39) Y167H possibly damaging Het
Prkab1 A G 5: 116,159,551 (GRCm39) L105P probably damaging Het
Ryr2 T A 13: 11,616,728 (GRCm39) I3897L possibly damaging Het
Sema3c A G 5: 17,916,434 (GRCm39) S469G probably benign Het
Serpinb3c T A 1: 107,200,914 (GRCm39) S168C probably damaging Het
Snapc4 A T 2: 26,253,736 (GRCm39) probably null Het
Sorcs2 A T 5: 36,205,153 (GRCm39) M528K probably damaging Het
Spink10 T A 18: 62,784,816 (GRCm39) probably null Het
Tent5b A T 4: 133,213,833 (GRCm39) probably null Het
Thsd7a C A 6: 12,554,980 (GRCm39) Q301H probably benign Het
Tshr A T 12: 91,486,077 (GRCm39) D217V possibly damaging Het
Ttyh1 G A 7: 4,128,720 (GRCm39) V206M possibly damaging Het
Tusc3 T G 8: 39,617,880 (GRCm39) *348G probably null Het
Vmn2r76 G A 7: 85,879,406 (GRCm39) T298I probably benign Het
Wdr47 T C 3: 108,518,712 (GRCm39) F67L probably damaging Het
Other mutations in Tmem135
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01459:Tmem135 APN 7 88,800,646 (GRCm39) missense probably damaging 1.00
IGL01933:Tmem135 APN 7 88,793,065 (GRCm39) unclassified probably benign
IGL02177:Tmem135 APN 7 88,987,661 (GRCm39) missense probably damaging 1.00
IGL02305:Tmem135 APN 7 88,814,331 (GRCm39) critical splice donor site probably null
IGL02747:Tmem135 APN 7 88,793,878 (GRCm39) missense probably damaging 0.98
IGL02801:Tmem135 APN 7 88,803,333 (GRCm39) missense probably benign 0.13
IGL03353:Tmem135 APN 7 88,791,161 (GRCm39) missense probably damaging 1.00
Skim UTSW 7 88,845,335 (GRCm39) nonsense probably null
R0631:Tmem135 UTSW 7 88,792,996 (GRCm39) nonsense probably null
R0657:Tmem135 UTSW 7 88,793,890 (GRCm39) missense probably damaging 0.96
R2233:Tmem135 UTSW 7 88,803,282 (GRCm39) missense probably damaging 1.00
R3118:Tmem135 UTSW 7 88,797,005 (GRCm39) missense probably benign 0.02
R3119:Tmem135 UTSW 7 88,797,005 (GRCm39) missense probably benign 0.02
R5094:Tmem135 UTSW 7 88,793,001 (GRCm39) missense probably damaging 1.00
R5225:Tmem135 UTSW 7 88,845,335 (GRCm39) nonsense probably null
R5248:Tmem135 UTSW 7 88,797,200 (GRCm39) missense probably damaging 1.00
R5356:Tmem135 UTSW 7 88,954,723 (GRCm39) missense probably benign 0.06
R5372:Tmem135 UTSW 7 88,814,382 (GRCm39) splice site probably null
R5442:Tmem135 UTSW 7 88,793,872 (GRCm39) missense probably damaging 1.00
R5789:Tmem135 UTSW 7 88,845,330 (GRCm39) missense possibly damaging 0.73
R5863:Tmem135 UTSW 7 88,797,176 (GRCm39) critical splice donor site probably null
R6158:Tmem135 UTSW 7 88,805,652 (GRCm39) missense probably benign 0.12
R6383:Tmem135 UTSW 7 88,793,878 (GRCm39) missense probably damaging 0.98
R6416:Tmem135 UTSW 7 88,797,002 (GRCm39) missense probably benign
R6659:Tmem135 UTSW 7 88,956,372 (GRCm39) nonsense probably null
R6659:Tmem135 UTSW 7 88,956,371 (GRCm39) missense probably benign 0.07
R6731:Tmem135 UTSW 7 88,893,172 (GRCm39) missense possibly damaging 0.96
R7545:Tmem135 UTSW 7 88,954,727 (GRCm39) missense probably damaging 1.00
R7626:Tmem135 UTSW 7 88,805,718 (GRCm39) splice site probably null
R8089:Tmem135 UTSW 7 88,805,703 (GRCm39) missense probably damaging 0.99
R8447:Tmem135 UTSW 7 88,803,240 (GRCm39) missense probably damaging 1.00
R8703:Tmem135 UTSW 7 88,808,170 (GRCm39) missense probably benign 0.00
R8750:Tmem135 UTSW 7 88,956,456 (GRCm39) missense probably damaging 0.99
R8758:Tmem135 UTSW 7 88,954,721 (GRCm39) missense probably benign 0.04
R8806:Tmem135 UTSW 7 88,797,186 (GRCm39) missense probably benign 0.25
R8807:Tmem135 UTSW 7 88,797,186 (GRCm39) missense probably benign 0.25
R8808:Tmem135 UTSW 7 88,797,186 (GRCm39) missense probably benign 0.25
R8835:Tmem135 UTSW 7 88,797,186 (GRCm39) missense probably benign 0.25
R8836:Tmem135 UTSW 7 88,797,186 (GRCm39) missense probably benign 0.25
R9093:Tmem135 UTSW 7 88,797,204 (GRCm39) missense probably benign 0.02
R9120:Tmem135 UTSW 7 88,797,186 (GRCm39) missense probably benign 0.25
R9122:Tmem135 UTSW 7 88,797,186 (GRCm39) missense probably benign 0.25
R9308:Tmem135 UTSW 7 88,797,186 (GRCm39) missense probably benign 0.25
R9649:Tmem135 UTSW 7 88,797,186 (GRCm39) missense probably benign 0.25
R9650:Tmem135 UTSW 7 88,797,186 (GRCm39) missense probably benign 0.25
Posted On 2014-01-21