Incidental Mutation 'IGL01730:Spink10'
ID 105461
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Spink10
Ensembl Gene ENSMUSG00000044176
Gene Name serine peptidase inhibitor, Kazal type 10
Synonyms A230091H23Rik
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL01730
Quality Score
Status
Chromosome 18
Chromosomal Location 62681982-62797412 bp(+) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) T to A at 62784816 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000125171 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000055725] [ENSMUST00000097557] [ENSMUST00000162365]
AlphaFold Q8CAC8
Predicted Effect probably null
Transcript: ENSMUST00000055725
SMART Domains Protein: ENSMUSP00000062976
Gene: ENSMUSG00000044176

DomainStartEndE-ValueType
KAZAL 34 78 2.85e-2 SMART
transmembrane domain 80 102 N/A INTRINSIC
KAZAL 111 162 2.61e-17 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000087562
Predicted Effect probably benign
Transcript: ENSMUST00000097557
SMART Domains Protein: ENSMUSP00000095165
Gene: ENSMUSG00000073551

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
KAZAL 50 96 9.26e-9 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000160316
Predicted Effect noncoding transcript
Transcript: ENSMUST00000161674
Predicted Effect probably null
Transcript: ENSMUST00000162365
SMART Domains Protein: ENSMUSP00000125171
Gene: ENSMUSG00000044176

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
KAZAL 34 78 2.85e-2 SMART
transmembrane domain 80 102 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Afap1 A G 5: 36,119,583 (GRCm39) E287G probably damaging Het
Bhmt A T 13: 93,761,917 (GRCm39) V122E probably damaging Het
Camta1 A G 4: 151,147,302 (GRCm39) I585T probably damaging Het
Cfap221 A G 1: 119,861,841 (GRCm39) S645P probably benign Het
Derl1 A T 15: 57,755,543 (GRCm39) F50Y possibly damaging Het
Dhrs3 T C 4: 144,646,042 (GRCm39) S117P probably damaging Het
E2f8 A T 7: 48,527,682 (GRCm39) probably benign Het
Fbn1 A T 2: 125,154,894 (GRCm39) probably benign Het
Fbxo15 A G 18: 84,982,299 (GRCm39) I250M probably benign Het
Ghr A T 15: 3,350,066 (GRCm39) S371T probably damaging Het
Gm5884 A T 6: 128,622,669 (GRCm39) noncoding transcript Het
Grhl2 T C 15: 37,338,018 (GRCm39) V496A probably benign Het
Gsap A G 5: 21,495,152 (GRCm39) probably benign Het
Irak3 T C 10: 120,014,005 (GRCm39) D148G probably benign Het
Itga2 A T 13: 114,990,947 (GRCm39) probably benign Het
Kif13b T C 14: 64,987,810 (GRCm39) probably null Het
Kif20b A T 19: 34,927,923 (GRCm39) K1022* probably null Het
Klhl17 G T 4: 156,316,157 (GRCm39) S399* probably null Het
Lcp2 A T 11: 34,000,943 (GRCm39) D42V possibly damaging Het
Lin7c G T 2: 109,726,785 (GRCm39) G145* probably null Het
Lrba A G 3: 86,648,731 (GRCm39) D2493G possibly damaging Het
Mobp A G 9: 119,996,992 (GRCm39) D41G probably damaging Het
Mycbp2 G A 14: 103,372,640 (GRCm39) Q785* probably null Het
Myl6b T C 10: 128,332,211 (GRCm39) Y85C possibly damaging Het
Nup133 G T 8: 124,664,972 (GRCm39) H240N probably benign Het
Or5b12 A C 19: 12,896,926 (GRCm39) F249C probably damaging Het
Plk4 T C 3: 40,760,285 (GRCm39) S394P probably benign Het
Prepl A G 17: 85,388,603 (GRCm39) Y167H possibly damaging Het
Prkab1 A G 5: 116,159,551 (GRCm39) L105P probably damaging Het
Ryr2 T A 13: 11,616,728 (GRCm39) I3897L possibly damaging Het
Sema3c A G 5: 17,916,434 (GRCm39) S469G probably benign Het
Serpinb3c T A 1: 107,200,914 (GRCm39) S168C probably damaging Het
Snapc4 A T 2: 26,253,736 (GRCm39) probably null Het
Sorcs2 A T 5: 36,205,153 (GRCm39) M528K probably damaging Het
Tent5b A T 4: 133,213,833 (GRCm39) probably null Het
Thsd7a C A 6: 12,554,980 (GRCm39) Q301H probably benign Het
Tmem135 A T 7: 88,797,252 (GRCm39) F335I possibly damaging Het
Tshr A T 12: 91,486,077 (GRCm39) D217V possibly damaging Het
Ttyh1 G A 7: 4,128,720 (GRCm39) V206M possibly damaging Het
Tusc3 T G 8: 39,617,880 (GRCm39) *348G probably null Het
Vmn2r76 G A 7: 85,879,406 (GRCm39) T298I probably benign Het
Wdr47 T C 3: 108,518,712 (GRCm39) F67L probably damaging Het
Other mutations in Spink10
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0491:Spink10 UTSW 18 62,793,036 (GRCm39) missense probably damaging 1.00
R3804:Spink10 UTSW 18 62,786,485 (GRCm39) unclassified probably benign
R3966:Spink10 UTSW 18 62,790,975 (GRCm39) missense probably damaging 0.99
R5991:Spink10 UTSW 18 62,790,956 (GRCm39) missense probably null 1.00
R8770:Spink10 UTSW 18 62,786,532 (GRCm39) missense probably benign 0.03
R9566:Spink10 UTSW 18 62,790,939 (GRCm39) missense probably benign 0.03
X0063:Spink10 UTSW 18 62,791,003 (GRCm39) splice site probably null
Posted On 2014-01-21