Incidental Mutation 'IGL01732:Zc3h6'
ID 105520
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zc3h6
Ensembl Gene ENSMUSG00000042851
Gene Name zinc finger CCCH type containing 6
Synonyms 4631426G04Rik, 4833425H18Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.168) question?
Stock # IGL01732
Quality Score
Status
Chromosome 2
Chromosomal Location 128809322-128860483 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 128853795 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 430 (I430T)
Ref Sequence ENSEMBL: ENSMUSP00000105949 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000110320]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000110320
AA Change: I430T

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000105949
Gene: ENSMUSG00000042851
AA Change: I430T

DomainStartEndE-ValueType
low complexity region 8 25 N/A INTRINSIC
coiled coil region 30 71 N/A INTRINSIC
low complexity region 74 88 N/A INTRINSIC
low complexity region 177 192 N/A INTRINSIC
ZnF_C3H1 271 296 1.72e-4 SMART
ZnF_C3H1 300 325 2.51e-6 SMART
ZnF_C3H1 326 349 5.24e0 SMART
coiled coil region 351 383 N/A INTRINSIC
low complexity region 385 400 N/A INTRINSIC
low complexity region 493 509 N/A INTRINSIC
low complexity region 698 707 N/A INTRINSIC
low complexity region 784 798 N/A INTRINSIC
low complexity region 815 829 N/A INTRINSIC
low complexity region 876 890 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aldh4a1 G T 4: 139,369,471 (GRCm39) E341* probably null Het
Alpk3 A G 7: 80,707,390 (GRCm39) R5G unknown Het
Arhgef10l C T 4: 140,307,726 (GRCm39) V113M probably damaging Het
Brca2 T A 5: 150,465,852 (GRCm39) I1872K probably benign Het
Cdk17 C A 10: 93,053,907 (GRCm39) P134T probably benign Het
Cerk A G 15: 86,030,517 (GRCm39) S35P possibly damaging Het
Cfap126 T C 1: 170,954,305 (GRCm39) V174A possibly damaging Het
Cfhr1 T C 1: 139,478,606 (GRCm39) T255A probably benign Het
Clcn1 A G 6: 42,287,606 (GRCm39) probably benign Het
Copz1 A G 15: 103,206,318 (GRCm39) E151G probably benign Het
Cubn G A 2: 13,494,747 (GRCm39) Q101* probably null Het
Eri1 T C 8: 35,958,397 (GRCm39) E12G possibly damaging Het
Fut9 A G 4: 25,619,867 (GRCm39) F316L possibly damaging Het
Garin1a A T 6: 29,285,979 (GRCm39) H146L probably damaging Het
Gm973 A G 1: 59,669,396 (GRCm39) I816V probably benign Het
Itln1 A G 1: 171,362,348 (GRCm39) M11T probably benign Het
Klc2 C T 19: 5,159,825 (GRCm39) R458Q probably damaging Het
Lrrc8b A T 5: 105,633,826 (GRCm39) E766V probably damaging Het
Mmadhc A T 2: 50,171,197 (GRCm39) I205N probably damaging Het
Myo10 A G 15: 25,732,149 (GRCm39) I342V probably benign Het
Ncapg T A 5: 45,851,195 (GRCm39) V796D probably damaging Het
Olfm3 A C 3: 114,890,649 (GRCm39) D134A possibly damaging Het
Or3a1c T C 11: 74,046,279 (GRCm39) C100R probably damaging Het
Or51t4 T A 7: 102,598,446 (GRCm39) I248N probably damaging Het
Or56b2 T C 7: 104,337,543 (GRCm39) M107T possibly damaging Het
Phldb3 A G 7: 24,326,751 (GRCm39) E593G probably damaging Het
Plcg1 T A 2: 160,589,699 (GRCm39) D74E probably damaging Het
Plekhm3 T C 1: 64,961,407 (GRCm39) D283G probably benign Het
Pnpla6 C A 8: 3,572,616 (GRCm39) T279N probably damaging Het
Prkcq G A 2: 11,265,644 (GRCm39) probably benign Het
Rbm11 G A 16: 75,397,510 (GRCm39) A147T probably benign Het
Rnf103 A G 6: 71,487,366 (GRCm39) K666E probably damaging Het
Selenos A G 7: 65,730,137 (GRCm39) Y45C probably damaging Het
Septin11 A G 5: 93,309,085 (GRCm39) Y255C probably damaging Het
Serpinb3c T C 1: 107,199,702 (GRCm39) H273R probably benign Het
Slc35f2 A G 9: 53,713,909 (GRCm39) D141G probably damaging Het
Sntg2 A T 12: 30,362,648 (GRCm39) Y33N probably damaging Het
Snx19 C A 9: 30,373,649 (GRCm39) T904K probably damaging Het
Tenm4 A G 7: 96,544,716 (GRCm39) Y2244C probably damaging Het
Tescl A G 7: 24,032,872 (GRCm39) V151A probably damaging Het
Tnrc18 C T 5: 142,757,816 (GRCm39) V902M unknown Het
Trmt13 A G 3: 116,375,113 (GRCm39) L465S probably damaging Het
Ube2j2 T G 4: 156,041,788 (GRCm39) V249G probably damaging Het
Zan T C 5: 137,391,273 (GRCm39) K4737R unknown Het
Zfp750 G A 11: 121,403,819 (GRCm39) S352L probably benign Het
Zfp819 A G 7: 43,265,846 (GRCm39) K34E probably benign Het
Other mutations in Zc3h6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01880:Zc3h6 APN 2 128,859,298 (GRCm39) missense probably damaging 0.99
IGL02160:Zc3h6 APN 2 128,839,605 (GRCm39) missense probably benign 0.02
IGL02161:Zc3h6 APN 2 128,835,146 (GRCm39) missense possibly damaging 0.90
IGL02202:Zc3h6 APN 2 128,858,501 (GRCm39) missense probably damaging 1.00
IGL02547:Zc3h6 APN 2 128,857,531 (GRCm39) missense probably benign 0.00
IGL02973:Zc3h6 APN 2 128,839,715 (GRCm39) missense probably damaging 0.98
BB001:Zc3h6 UTSW 2 128,857,400 (GRCm39) missense possibly damaging 0.52
BB011:Zc3h6 UTSW 2 128,857,400 (GRCm39) missense possibly damaging 0.52
R0336:Zc3h6 UTSW 2 128,857,332 (GRCm39) missense possibly damaging 0.81
R0420:Zc3h6 UTSW 2 128,856,747 (GRCm39) missense probably benign 0.00
R0538:Zc3h6 UTSW 2 128,859,143 (GRCm39) missense possibly damaging 0.75
R0944:Zc3h6 UTSW 2 128,848,736 (GRCm39) missense probably damaging 1.00
R1151:Zc3h6 UTSW 2 128,859,056 (GRCm39) missense probably benign 0.00
R1528:Zc3h6 UTSW 2 128,858,989 (GRCm39) missense probably benign 0.01
R1698:Zc3h6 UTSW 2 128,859,278 (GRCm39) missense probably benign
R1712:Zc3h6 UTSW 2 128,858,654 (GRCm39) missense probably damaging 1.00
R1913:Zc3h6 UTSW 2 128,858,540 (GRCm39) missense probably damaging 1.00
R1926:Zc3h6 UTSW 2 128,839,715 (GRCm39) missense probably damaging 0.98
R2030:Zc3h6 UTSW 2 128,848,006 (GRCm39) missense probably damaging 1.00
R2051:Zc3h6 UTSW 2 128,857,538 (GRCm39) missense possibly damaging 0.55
R2133:Zc3h6 UTSW 2 128,809,750 (GRCm39) missense possibly damaging 0.53
R2273:Zc3h6 UTSW 2 128,856,629 (GRCm39) missense probably benign 0.01
R2328:Zc3h6 UTSW 2 128,835,122 (GRCm39) missense possibly damaging 0.85
R2862:Zc3h6 UTSW 2 128,857,380 (GRCm39) missense probably benign 0.43
R2899:Zc3h6 UTSW 2 128,844,152 (GRCm39) missense probably benign 0.00
R3711:Zc3h6 UTSW 2 128,859,251 (GRCm39) missense probably benign 0.00
R3743:Zc3h6 UTSW 2 128,839,712 (GRCm39) missense probably damaging 1.00
R3893:Zc3h6 UTSW 2 128,858,060 (GRCm39) missense probably damaging 1.00
R4748:Zc3h6 UTSW 2 128,844,160 (GRCm39) missense probably damaging 1.00
R5025:Zc3h6 UTSW 2 128,852,353 (GRCm39) missense possibly damaging 0.87
R5026:Zc3h6 UTSW 2 128,859,229 (GRCm39) missense probably benign 0.00
R5125:Zc3h6 UTSW 2 128,856,399 (GRCm39) missense possibly damaging 0.93
R5373:Zc3h6 UTSW 2 128,844,076 (GRCm39) missense possibly damaging 0.75
R5374:Zc3h6 UTSW 2 128,844,076 (GRCm39) missense possibly damaging 0.75
R5703:Zc3h6 UTSW 2 128,835,372 (GRCm39) intron probably benign
R5802:Zc3h6 UTSW 2 128,857,479 (GRCm39) missense possibly damaging 0.56
R5876:Zc3h6 UTSW 2 128,835,197 (GRCm39) missense probably benign 0.29
R5879:Zc3h6 UTSW 2 128,839,696 (GRCm39) splice site probably null
R5950:Zc3h6 UTSW 2 128,839,710 (GRCm39) nonsense probably null
R6031:Zc3h6 UTSW 2 128,809,732 (GRCm39) missense possibly damaging 0.85
R6031:Zc3h6 UTSW 2 128,809,732 (GRCm39) missense possibly damaging 0.85
R6781:Zc3h6 UTSW 2 128,857,341 (GRCm39) missense probably damaging 0.99
R7323:Zc3h6 UTSW 2 128,835,331 (GRCm39) missense unknown
R7340:Zc3h6 UTSW 2 128,835,110 (GRCm39) missense possibly damaging 0.90
R7572:Zc3h6 UTSW 2 128,859,172 (GRCm39) missense probably benign 0.02
R7576:Zc3h6 UTSW 2 128,856,473 (GRCm39) missense probably damaging 1.00
R7797:Zc3h6 UTSW 2 128,857,555 (GRCm39) critical splice donor site probably null
R7924:Zc3h6 UTSW 2 128,857,400 (GRCm39) missense possibly damaging 0.52
R8048:Zc3h6 UTSW 2 128,858,934 (GRCm39) missense probably benign 0.30
R8877:Zc3h6 UTSW 2 128,856,319 (GRCm39) nonsense probably null
R9076:Zc3h6 UTSW 2 128,859,096 (GRCm39) nonsense probably null
R9577:Zc3h6 UTSW 2 128,858,102 (GRCm39) missense
R9687:Zc3h6 UTSW 2 128,859,281 (GRCm39) missense probably damaging 1.00
R9745:Zc3h6 UTSW 2 128,859,155 (GRCm39) missense probably benign 0.08
Z1176:Zc3h6 UTSW 2 128,858,141 (GRCm39) missense probably benign 0.01
Posted On 2014-01-21