Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01732:Itln1'

105537

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Itln1

Ensembl Gene

ENSMUSG00000038209

Gene Name

intelectin 1 (galactofuranose binding)

Synonyms

Itlna, IntL, mLfR, Itln2

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL01732

Quality Score

Status

Chromosome

Chromosomal Location

171345690-171362862 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 171362348 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Threonine at position 11 (M11T)

Ref Sequence

ENSEMBL: ENSMUSP00000043837 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000043094] [ENSMUST00000168184]

AlphaFold

O88310

Predicted Effect

probably benign
Transcript: ENSMUST00000043094
AA Change: M11T

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000043837
Gene: ENSMUSG00000038209
AA Change: M11T

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
FBG	36	211	3.77e0	SMART
Blast:FBG	230	312	8e-47	BLAST

Predicted Effect

probably benign
Transcript: ENSMUST00000168184

SMART Domains

Protein: ENSMUSP00000126385
Gene: ENSMUSG00000038209

Domain	Start	End	E-Value	Type
Blast:FBG	1	108	2e-60	BLAST
SCOP:d1jc9a_	7	68	5e-5	SMART

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Phenotypic analysis of mice homozygous for a targeted null allele indicates this mutation has no notable phenotype in any parameter tested. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 46 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aldh4a1	G	T	4: 139,369,471 (GRCm39)	E341*	probably null	Het
Alpk3	A	G	7: 80,707,390 (GRCm39)	R5G	unknown	Het
Arhgef10l	C	T	4: 140,307,726 (GRCm39)	V113M	probably damaging	Het
Brca2	T	A	5: 150,465,852 (GRCm39)	I1872K	probably benign	Het
Cdk17	C	A	10: 93,053,907 (GRCm39)	P134T	probably benign	Het
Cerk	A	G	15: 86,030,517 (GRCm39)	S35P	possibly damaging	Het
Cfap126	T	C	1: 170,954,305 (GRCm39)	V174A	possibly damaging	Het
Cfhr1	T	C	1: 139,478,606 (GRCm39)	T255A	probably benign	Het
Clcn1	A	G	6: 42,287,606 (GRCm39)		probably benign	Het
Copz1	A	G	15: 103,206,318 (GRCm39)	E151G	probably benign	Het
Cubn	G	A	2: 13,494,747 (GRCm39)	Q101*	probably null	Het
Eri1	T	C	8: 35,958,397 (GRCm39)	E12G	possibly damaging	Het
Fut9	A	G	4: 25,619,867 (GRCm39)	F316L	possibly damaging	Het
Garin1a	A	T	6: 29,285,979 (GRCm39)	H146L	probably damaging	Het
Gm973	A	G	1: 59,669,396 (GRCm39)	I816V	probably benign	Het
Klc2	C	T	19: 5,159,825 (GRCm39)	R458Q	probably damaging	Het
Lrrc8b	A	T	5: 105,633,826 (GRCm39)	E766V	probably damaging	Het
Mmadhc	A	T	2: 50,171,197 (GRCm39)	I205N	probably damaging	Het
Myo10	A	G	15: 25,732,149 (GRCm39)	I342V	probably benign	Het
Ncapg	T	A	5: 45,851,195 (GRCm39)	V796D	probably damaging	Het
Olfm3	A	C	3: 114,890,649 (GRCm39)	D134A	possibly damaging	Het
Or3a1c	T	C	11: 74,046,279 (GRCm39)	C100R	probably damaging	Het
Or51t4	T	A	7: 102,598,446 (GRCm39)	I248N	probably damaging	Het
Or56b2	T	C	7: 104,337,543 (GRCm39)	M107T	possibly damaging	Het
Phldb3	A	G	7: 24,326,751 (GRCm39)	E593G	probably damaging	Het
Plcg1	T	A	2: 160,589,699 (GRCm39)	D74E	probably damaging	Het
Plekhm3	T	C	1: 64,961,407 (GRCm39)	D283G	probably benign	Het
Pnpla6	C	A	8: 3,572,616 (GRCm39)	T279N	probably damaging	Het
Prkcq	G	A	2: 11,265,644 (GRCm39)		probably benign	Het
Rbm11	G	A	16: 75,397,510 (GRCm39)	A147T	probably benign	Het
Rnf103	A	G	6: 71,487,366 (GRCm39)	K666E	probably damaging	Het
Selenos	A	G	7: 65,730,137 (GRCm39)	Y45C	probably damaging	Het
Septin11	A	G	5: 93,309,085 (GRCm39)	Y255C	probably damaging	Het
Serpinb3c	T	C	1: 107,199,702 (GRCm39)	H273R	probably benign	Het
Slc35f2	A	G	9: 53,713,909 (GRCm39)	D141G	probably damaging	Het
Sntg2	A	T	12: 30,362,648 (GRCm39)	Y33N	probably damaging	Het
Snx19	C	A	9: 30,373,649 (GRCm39)	T904K	probably damaging	Het
Tenm4	A	G	7: 96,544,716 (GRCm39)	Y2244C	probably damaging	Het
Tescl	A	G	7: 24,032,872 (GRCm39)	V151A	probably damaging	Het
Tnrc18	C	T	5: 142,757,816 (GRCm39)	V902M	unknown	Het
Trmt13	A	G	3: 116,375,113 (GRCm39)	L465S	probably damaging	Het
Ube2j2	T	G	4: 156,041,788 (GRCm39)	V249G	probably damaging	Het
Zan	T	C	5: 137,391,273 (GRCm39)	K4737R	unknown	Het
Zc3h6	T	C	2: 128,853,795 (GRCm39)	I430T	probably damaging	Het
Zfp750	G	A	11: 121,403,819 (GRCm39)	S352L	probably benign	Het
Zfp819	A	G	7: 43,265,846 (GRCm39)	K34E	probably benign	Het

Other mutations in Itln1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01817:Itln1	APN	1	171,356,728 (GRCm39)	missense	probably damaging	1.00
IGL02440:Itln1	APN	1	171,359,097 (GRCm39)	missense	probably benign	0.07
IGL03204:Itln1	APN	1	171,358,172 (GRCm39)	missense	probably damaging	0.99
BB003:Itln1	UTSW	1	171,359,261 (GRCm39)	missense	probably benign	0.23
BB013:Itln1	UTSW	1	171,359,261 (GRCm39)	missense	probably benign	0.23
R0331:Itln1	UTSW	1	171,359,117 (GRCm39)	missense	probably damaging	0.99
R0881:Itln1	UTSW	1	171,360,949 (GRCm39)	missense	probably benign
R0971:Itln1	UTSW	1	171,356,772 (GRCm39)	missense	probably damaging	0.98
R1168:Itln1	UTSW	1	171,359,119 (GRCm39)	nonsense	probably null
R2219:Itln1	UTSW	1	171,359,115 (GRCm39)	missense	probably damaging	1.00
R2504:Itln1	UTSW	1	171,356,727 (GRCm39)	missense	probably damaging	1.00
R4230:Itln1	UTSW	1	171,362,375 (GRCm39)	missense	probably benign	0.00
R4695:Itln1	UTSW	1	171,358,645 (GRCm39)	missense	probably damaging	0.98
R5011:Itln1	UTSW	1	171,360,958 (GRCm39)	nonsense	probably null
R5013:Itln1	UTSW	1	171,360,958 (GRCm39)	nonsense	probably null
R5756:Itln1	UTSW	1	171,344,485 (GRCm39)	unclassified	probably benign
R5806:Itln1	UTSW	1	171,358,720 (GRCm39)	missense	possibly damaging	0.93
R6651:Itln1	UTSW	1	171,345,940 (GRCm39)	missense	possibly damaging	0.56
R6703:Itln1	UTSW	1	171,358,151 (GRCm39)	missense	probably damaging	1.00
R7128:Itln1	UTSW	1	171,358,143 (GRCm39)	missense	possibly damaging	0.92
R7850:Itln1	UTSW	1	171,358,166 (GRCm39)	missense	probably damaging	1.00
R7926:Itln1	UTSW	1	171,359,261 (GRCm39)	missense	probably benign	0.23
R8694:Itln1	UTSW	1	171,359,279 (GRCm39)	missense	probably damaging	1.00
R9627:Itln1	UTSW	1	171,360,985 (GRCm39)	missense	probably benign	0.01
X0019:Itln1	UTSW	1	171,358,139 (GRCm39)	missense	probably damaging	0.99

Posted On

2014-01-21