Incidental Mutation 'IGL01732:Slc35f2'
ID105556
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Slc35f2
Ensembl Gene ENSMUSG00000042195
Gene Namesolute carrier family 35, member F2
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.113) question?
Stock #IGL01732
Quality Score
Status
Chromosome9
Chromosomal Location53771538-53818154 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 53806625 bp
ZygosityHeterozygous
Amino Acid Change Aspartic acid to Glycine at position 141 (D141G)
Ref Sequence ENSEMBL: ENSMUSP00000046528 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000048670]
Predicted Effect probably damaging
Transcript: ENSMUST00000048670
AA Change: D141G

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000046528
Gene: ENSMUSG00000042195
AA Change: D141G

DomainStartEndE-ValueType
low complexity region 2 16 N/A INTRINSIC
Pfam:SLC35F 35 334 7.2e-148 PFAM
Pfam:CRT-like 47 255 4.5e-14 PFAM
Pfam:EamA 196 334 2.1e-10 PFAM
low complexity region 339 352 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000216515
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aldh4a1 G T 4: 139,642,160 E341* probably null Het
Alpk3 A G 7: 81,057,642 R5G unknown Het
Arhgef10l C T 4: 140,580,415 V113M probably damaging Het
Brca2 T A 5: 150,542,387 I1872K probably benign Het
Cdk17 C A 10: 93,218,045 P134T probably benign Het
Cerk A G 15: 86,146,316 S35P possibly damaging Het
Cfap126 T C 1: 171,126,736 V174A possibly damaging Het
Cfhr1 T C 1: 139,550,868 T255A probably benign Het
Clcn1 A G 6: 42,310,672 probably benign Het
Copz1 A G 15: 103,297,891 E151G probably benign Het
Cubn G A 2: 13,489,936 Q101* probably null Het
Eri1 T C 8: 35,491,243 E12G possibly damaging Het
Fam71f2 A T 6: 29,285,980 H146L probably damaging Het
Fut9 A G 4: 25,619,867 F316L possibly damaging Het
Gm973 A G 1: 59,630,237 I816V probably benign Het
Itln1 A G 1: 171,534,780 M11T probably benign Het
Klc2 C T 19: 5,109,797 R458Q probably damaging Het
Lrrc8b A T 5: 105,485,960 E766V probably damaging Het
Mmadhc A T 2: 50,281,185 I205N probably damaging Het
Myo10 A G 15: 25,732,063 I342V probably benign Het
Ncapg T A 5: 45,693,853 V796D probably damaging Het
Olfm3 A C 3: 115,097,000 D134A possibly damaging Het
Olfr402 T C 11: 74,155,453 C100R probably damaging Het
Olfr574 T A 7: 102,949,239 I248N probably damaging Het
Olfr661 T C 7: 104,688,336 M107T possibly damaging Het
Phldb3 A G 7: 24,627,326 E593G probably damaging Het
Plcg1 T A 2: 160,747,779 D74E probably damaging Het
Plekhm3 T C 1: 64,922,248 D283G probably benign Het
Pnpla6 C A 8: 3,522,616 T279N probably damaging Het
Prkcq G A 2: 11,260,833 probably benign Het
Rbm11 G A 16: 75,600,622 A147T probably benign Het
Rnf103 A G 6: 71,510,382 K666E probably damaging Het
Selenos A G 7: 66,080,389 Y45C probably damaging Het
Sept11 A G 5: 93,161,226 Y255C probably damaging Het
Serpinb3c T C 1: 107,271,972 H273R probably benign Het
Sntg2 A T 12: 30,312,649 Y33N probably damaging Het
Snx19 C A 9: 30,462,353 T904K probably damaging Het
Tenm4 A G 7: 96,895,509 Y2244C probably damaging Het
Tescl A G 7: 24,333,447 V151A probably damaging Het
Tnrc18 C T 5: 142,772,061 V902M unknown Het
Trmt13 A G 3: 116,581,464 L465S probably damaging Het
Ube2j2 T G 4: 155,957,331 V249G probably damaging Het
Zan T C 5: 137,393,011 K4737R unknown Het
Zc3h6 T C 2: 129,011,875 I430T probably damaging Het
Zfp750 G A 11: 121,512,993 S352L probably benign Het
Zfp819 A G 7: 43,616,422 K34E probably benign Het
Other mutations in Slc35f2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00465:Slc35f2 APN 9 53798014 critical splice donor site probably null
IGL01476:Slc35f2 APN 9 53806706 missense possibly damaging 0.88
IGL02719:Slc35f2 APN 9 53809742 splice site probably benign
R0449:Slc35f2 UTSW 9 53816917 missense probably damaging 1.00
R1268:Slc35f2 UTSW 9 53797913 nonsense probably null
R1539:Slc35f2 UTSW 9 53809708 missense possibly damaging 0.66
R3886:Slc35f2 UTSW 9 53816957 missense probably benign 0.00
R4748:Slc35f2 UTSW 9 53771785 start codon destroyed probably benign 0.23
R4779:Slc35f2 UTSW 9 53809729 missense possibly damaging 0.80
R5438:Slc35f2 UTSW 9 53801018 missense probably benign
R7308:Slc35f2 UTSW 9 53798010 missense probably benign 0.00
R7520:Slc35f2 UTSW 9 53801101 missense possibly damaging 0.57
R7680:Slc35f2 UTSW 9 53808112 missense probably damaging 1.00
Posted On2014-01-21