Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01733:Cuedc2'

105567

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Cuedc2

Ensembl Gene

ENSMUSG00000036748

Gene Name

CUE domain containing 2

Synonyms

3010002G01Rik

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.253) question?

Stock #

IGL01733

Quality Score

Status

Chromosome

Chromosomal Location

46318251-46327141 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to A at 46321112 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Phenylalanine at position 7 (V7F)

Ref Sequence

ENSEMBL: ENSMUSP00000129589 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000026256] [ENSMUST00000051234] [ENSMUST00000167861] [ENSMUST00000177667]

AlphaFold

Q9CXX9

Predicted Effect

probably benign
Transcript: ENSMUST00000026256

SMART Domains

Protein: ENSMUSP00000026256
Gene: ENSMUSG00000025226

Domain	Start	End	E-Value	Type
Pfam:F-box	18	63	1.9e-6	PFAM
low complexity region	76	84	N/A	INTRINSIC
LRR	113	138	1.01e1	SMART
LRR	139	164	1.89e-1	SMART
LRR	165	190	2.27e-4	SMART
LRR	192	217	3.47e0	SMART
LRR	218	243	2.57e-3	SMART
LRR	244	269	2.05e1	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000051234
AA Change: V7F

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000053469
Gene: ENSMUSG00000036748
AA Change: V7F

Domain	Start	End	E-Value	Type
Pfam:CUE	144	183	4.6e-7	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000167861
AA Change: V7F

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000129589
Gene: ENSMUSG00000036748
AA Change: V7F

Domain	Start	End	E-Value	Type
Pfam:CUE	144	183	5.7e-7	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000177667

SMART Domains

Protein: ENSMUSP00000137489
Gene: ENSMUSG00000025226

Domain	Start	End	E-Value	Type
Pfam:F-box	18	63	2.1e-6	PFAM
low complexity region	76	84	N/A	INTRINSIC
LRR	113	138	1.01e1	SMART
LRR	139	164	1.89e-1	SMART
LRR	165	190	2.27e-4	SMART
LRR	192	217	3.47e0	SMART
LRR	218	243	2.57e-3	SMART
LRR	244	269	2.05e1	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000180538

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 35 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcd2	C	T	15: 91,075,817 (GRCm39)		probably benign	Het
Aco1	T	G	4: 40,175,738 (GRCm39)		probably benign	Het
Brinp3	T	C	1: 146,390,541 (GRCm39)	V29A	probably benign	Het
Brsk1	T	C	7: 4,709,071 (GRCm39)	Y361H	probably damaging	Het
Ccdc178	G	T	18: 22,157,869 (GRCm39)		probably benign	Het
Ces1f	A	G	8: 93,996,642 (GRCm39)	I217T	probably damaging	Het
Col6a6	T	A	9: 105,586,454 (GRCm39)	T1856S	possibly damaging	Het
Cyp2d34	C	T	15: 82,502,861 (GRCm39)	V122M	possibly damaging	Het
Ddx60	T	C	8: 62,436,899 (GRCm39)	S949P	probably damaging	Het
Dlg5	G	A	14: 24,220,517 (GRCm39)	R554W	probably damaging	Het
Fig4	A	T	10: 41,153,389 (GRCm39)	N137K	possibly damaging	Het
Gpr155	C	T	2: 73,183,956 (GRCm39)		probably null	Het
Grk6	A	C	13: 55,599,204 (GRCm39)	N168T	possibly damaging	Het
Hfe	T	G	13: 23,890,848 (GRCm39)	K97T	possibly damaging	Het
Hsd3b2	C	T	3: 98,623,801 (GRCm39)	E26K	probably damaging	Het
Impg1	A	G	9: 80,249,206 (GRCm39)	S666P	probably damaging	Het
Itpkb	T	G	1: 180,160,734 (GRCm39)	S287A	possibly damaging	Het
Kcnh5	T	C	12: 75,011,966 (GRCm39)	D651G	probably benign	Het
Lemd3	C	T	10: 120,769,568 (GRCm39)	W588*	probably null	Het
Lepr	A	G	4: 101,622,279 (GRCm39)	T404A	probably benign	Het
Metap1d	A	G	2: 71,341,777 (GRCm39)	I124V	probably damaging	Het
Mrpl33	T	C	5: 31,779,733 (GRCm39)	V54A	probably benign	Het
Mybl1	A	T	1: 9,755,935 (GRCm39)	S205T	possibly damaging	Het
Mybpc2	T	A	7: 44,155,622 (GRCm39)	D877V	probably benign	Het
Nxph2	T	C	2: 23,290,137 (GRCm39)	V163A	probably benign	Het
Pakap	G	T	4: 57,856,488 (GRCm39)	V606L	probably benign	Het
Pex16	C	T	2: 92,209,173 (GRCm39)	P192S	probably damaging	Het
Ptprq	C	A	10: 107,498,460 (GRCm39)	M872I	probably benign	Het
Ripor1	C	T	8: 106,342,378 (GRCm39)	R150W	possibly damaging	Het
Spns2	A	T	11: 72,347,336 (GRCm39)	V423E	possibly damaging	Het
St6galnac2	C	T	11: 116,575,945 (GRCm39)	D169N	probably damaging	Het
Stoml3	A	G	3: 53,405,548 (GRCm39)	I50V	probably benign	Het
Taar8c	A	G	10: 23,977,155 (GRCm39)	I219T	possibly damaging	Het
Ubap2	A	C	4: 41,195,862 (GRCm39)		probably benign	Het
Zfat	T	C	15: 68,052,579 (GRCm39)	D398G	probably damaging	Het

Other mutations in Cuedc2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00164:Cuedc2	APN	19	46,320,359 (GRCm39)	missense	probably damaging	1.00
IGL01155:Cuedc2	APN	19	46,321,088 (GRCm39)	missense	probably damaging	1.00
R1656:Cuedc2	UTSW	19	46,320,427 (GRCm39)	missense	probably damaging	0.99
R1778:Cuedc2	UTSW	19	46,320,079 (GRCm39)	missense	probably benign	0.00
R2905:Cuedc2	UTSW	19	46,321,088 (GRCm39)	missense	probably benign	0.16
R5801:Cuedc2	UTSW	19	46,319,796 (GRCm39)	missense	probably damaging	0.99
R5874:Cuedc2	UTSW	19	46,319,824 (GRCm39)	missense	possibly damaging	0.71
R8511:Cuedc2	UTSW	19	46,319,358 (GRCm39)	critical splice donor site	probably null
R9483:Cuedc2	UTSW	19	46,319,399 (GRCm39)	missense	probably benign	0.10
R9742:Cuedc2	UTSW	19	46,319,727 (GRCm39)	critical splice donor site	probably null

Posted On

2014-01-21