Incidental Mutation 'IGL01734:Fbxw22'
ID 105607
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Fbxw22
Ensembl Gene ENSMUSG00000070324
Gene Name F-box and WD-40 domain protein 22
Synonyms Gm5164
Accession Numbers
Essential gene? Probably non essential (E-score: 0.058) question?
Stock # IGL01734
Quality Score
Status
Chromosome 9
Chromosomal Location 109207468-109233362 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 109212993 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Arginine at position 318 (M318R)
Ref Sequence ENSEMBL: ENSMUSP00000079460 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000080626] [ENSMUST00000197213]
AlphaFold Q5XG67
Predicted Effect probably damaging
Transcript: ENSMUST00000080626
AA Change: M318R

PolyPhen 2 Score 0.982 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000079460
Gene: ENSMUSG00000070324
AA Change: M318R

DomainStartEndE-ValueType
FBOX 5 45 1.02e-5 SMART
SCOP:d1gxra_ 128 220 1e-5 SMART
Blast:WD40 137 176 6e-9 BLAST
Predicted Effect probably benign
Transcript: ENSMUST00000197213
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4932442E05Rik T A 10: 118,697,371 (GRCm39) W210R possibly damaging Het
Aknad1 T C 3: 108,659,217 (GRCm39) M77T probably benign Het
Aox1 A T 1: 58,393,469 (GRCm39) I1210F possibly damaging Het
Brd8 A T 18: 34,747,858 (GRCm39) probably benign Het
Cdh23 T C 10: 60,139,292 (GRCm39) D3307G probably benign Het
Chsy1 T C 7: 65,821,058 (GRCm39) I431T probably damaging Het
Cobl A G 11: 12,204,980 (GRCm39) probably benign Het
Col28a1 T C 6: 8,158,134 (GRCm39) D308G probably damaging Het
Csmd3 A G 15: 48,048,700 (GRCm39) Y568H probably damaging Het
Dmrt3 T C 19: 25,599,947 (GRCm39) I264T probably damaging Het
Dusp22 G T 13: 30,880,235 (GRCm39) C52F probably damaging Het
Ffar4 C T 19: 38,102,295 (GRCm39) T310M probably damaging Het
Fn1 A G 1: 71,658,644 (GRCm39) V1138A probably damaging Het
Glt6d1 T A 2: 25,684,505 (GRCm39) Y167F probably benign Het
Hydin T A 8: 111,217,421 (GRCm39) Y1436* probably null Het
Il12a G A 3: 68,598,888 (GRCm39) C2Y possibly damaging Het
Inpp5a T C 7: 139,034,006 (GRCm39) Y38H possibly damaging Het
Jmy A C 13: 93,596,159 (GRCm39) L490R probably damaging Het
Kif26a T A 12: 112,143,262 (GRCm39) L1172H probably benign Het
Kmo A T 1: 175,482,668 (GRCm39) M331L probably benign Het
Lonp1 G A 17: 56,923,026 (GRCm39) T627M probably damaging Het
Lrrc41 T C 4: 115,950,331 (GRCm39) probably null Het
Mast4 A T 13: 102,874,123 (GRCm39) S1556R probably damaging Het
Mmel1 A G 4: 154,976,408 (GRCm39) N490S probably benign Het
Mpped2 A G 2: 106,614,158 (GRCm39) D164G probably damaging Het
Nap1l1 A G 10: 111,328,760 (GRCm39) T230A probably benign Het
Nrap C A 19: 56,338,741 (GRCm39) A913S probably damaging Het
Nudt16 G T 9: 105,008,707 (GRCm39) Q65K probably benign Het
Or1e23 C A 11: 73,407,462 (GRCm39) A188S probably benign Het
Or5ac17 T G 16: 59,036,792 (GRCm39) L61F probably benign Het
Or5ac19 T A 16: 59,089,213 (GRCm39) K272N probably benign Het
Or5al5 T A 2: 85,962,012 (GRCm39) probably benign Het
Or6c76b T A 10: 129,692,671 (GRCm39) C95S probably benign Het
Parp14 A G 16: 35,678,970 (GRCm39) F333L probably benign Het
Pi4ka G T 16: 17,115,124 (GRCm39) Q1422K probably benign Het
Polr3c T C 3: 96,620,836 (GRCm39) E494G probably damaging Het
Prss42 C A 9: 110,627,411 (GRCm39) P49Q probably benign Het
Ptpra C T 2: 130,385,997 (GRCm39) T568I probably damaging Het
Ring1 T C 17: 34,242,294 (GRCm39) D71G probably damaging Het
Siae T A 9: 37,542,782 (GRCm39) S193T probably damaging Het
Slf2 T C 19: 44,961,706 (GRCm39) probably null Het
Spinkl T A 18: 44,307,639 (GRCm39) K7N possibly damaging Het
Tbk1 G A 10: 121,407,888 (GRCm39) R82* probably null Het
Tcf12 T C 9: 71,829,930 (GRCm39) probably null Het
Tcl1b5 G A 12: 105,145,214 (GRCm39) M59I probably benign Het
Thumpd3 C A 6: 113,043,806 (GRCm39) T407K probably damaging Het
Timm29 T C 9: 21,505,031 (GRCm39) V233A probably damaging Het
Tns3 A G 11: 8,469,192 (GRCm39) probably benign Het
Ubash3b T C 9: 40,937,543 (GRCm39) probably benign Het
Ugdh G T 5: 65,580,031 (GRCm39) T253K probably benign Het
Zfp143 T A 7: 109,671,416 (GRCm39) probably benign Het
Zfp738 A G 13: 67,831,563 (GRCm39) probably benign Het
Other mutations in Fbxw22
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00592:Fbxw22 APN 9 109,213,108 (GRCm39) missense possibly damaging 0.68
IGL00655:Fbxw22 APN 9 109,211,312 (GRCm39) splice site probably benign
IGL01122:Fbxw22 APN 9 109,215,739 (GRCm39) missense probably damaging 0.99
IGL01419:Fbxw22 APN 9 109,210,790 (GRCm39) missense probably benign 0.03
IGL01455:Fbxw22 APN 9 109,214,062 (GRCm39) missense probably benign
IGL01486:Fbxw22 APN 9 109,207,941 (GRCm39) missense probably damaging 1.00
IGL02106:Fbxw22 APN 9 109,231,087 (GRCm39) missense possibly damaging 0.86
IGL02255:Fbxw22 APN 9 109,215,619 (GRCm39) splice site probably benign
IGL02466:Fbxw22 APN 9 109,214,160 (GRCm39) missense probably damaging 1.00
IGL02820:Fbxw22 APN 9 109,215,732 (GRCm39) missense probably damaging 1.00
R0395:Fbxw22 UTSW 9 109,210,753 (GRCm39) missense probably damaging 1.00
R0705:Fbxw22 UTSW 9 109,232,164 (GRCm39) missense possibly damaging 0.92
R0741:Fbxw22 UTSW 9 109,211,287 (GRCm39) missense probably benign 0.01
R1603:Fbxw22 UTSW 9 109,207,915 (GRCm39) missense probably benign 0.00
R1673:Fbxw22 UTSW 9 109,211,196 (GRCm39) missense possibly damaging 0.93
R1874:Fbxw22 UTSW 9 109,214,179 (GRCm39) nonsense probably null
R2265:Fbxw22 UTSW 9 109,213,062 (GRCm39) missense probably benign 0.02
R2269:Fbxw22 UTSW 9 109,213,062 (GRCm39) missense probably benign 0.02
R2385:Fbxw22 UTSW 9 109,211,210 (GRCm39) missense probably damaging 1.00
R4329:Fbxw22 UTSW 9 109,213,111 (GRCm39) missense probably damaging 1.00
R4695:Fbxw22 UTSW 9 109,207,939 (GRCm39) missense probably damaging 1.00
R4731:Fbxw22 UTSW 9 109,207,937 (GRCm39) missense probably benign 0.02
R4915:Fbxw22 UTSW 9 109,213,009 (GRCm39) missense probably damaging 1.00
R5010:Fbxw22 UTSW 9 109,232,492 (GRCm39) missense probably benign 0.40
R5070:Fbxw22 UTSW 9 109,214,183 (GRCm39) missense probably benign
R5319:Fbxw22 UTSW 9 109,213,015 (GRCm39) missense possibly damaging 0.52
R5571:Fbxw22 UTSW 9 109,232,156 (GRCm39) missense probably damaging 1.00
R5765:Fbxw22 UTSW 9 109,214,064 (GRCm39) missense probably benign 0.00
R5846:Fbxw22 UTSW 9 109,215,829 (GRCm39) missense probably benign
R6002:Fbxw22 UTSW 9 109,210,750 (GRCm39) nonsense probably null
R6180:Fbxw22 UTSW 9 109,215,747 (GRCm39) missense probably damaging 1.00
R6313:Fbxw22 UTSW 9 109,232,465 (GRCm39) missense probably damaging 0.99
R6860:Fbxw22 UTSW 9 109,213,030 (GRCm39) missense probably benign 0.01
R6949:Fbxw22 UTSW 9 109,211,144 (GRCm39) missense probably benign 0.06
R7084:Fbxw22 UTSW 9 109,233,291 (GRCm39) missense probably damaging 1.00
R7296:Fbxw22 UTSW 9 109,211,143 (GRCm39) missense probably benign
R8499:Fbxw22 UTSW 9 109,214,068 (GRCm39) missense probably benign 0.00
R9088:Fbxw22 UTSW 9 109,207,952 (GRCm39) missense probably damaging 1.00
R9301:Fbxw22 UTSW 9 109,215,653 (GRCm39) missense possibly damaging 0.60
R9501:Fbxw22 UTSW 9 109,207,920 (GRCm39) missense probably benign 0.01
R9600:Fbxw22 UTSW 9 109,212,986 (GRCm39) missense probably damaging 1.00
Posted On 2014-01-21