Incidental Mutation 'IGL01737:Trim12c'
ID105725
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Trim12c
Ensembl Gene ENSMUSG00000057143
Gene Nametripartite motif-containing 12C
SynonymsTrim12-2, 9230105E10Rik
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.081) question?
Stock #IGL01737
Quality Score
Status
Chromosome7
Chromosomal Location104338754-104353362 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 104348062 bp
ZygosityHeterozygous
Amino Acid Change Cysteine to Arginine at position 96 (C96R)
Ref Sequence ENSEMBL: ENSMUSP00000116775 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000059037] [ENSMUST00000130139]
Predicted Effect probably damaging
Transcript: ENSMUST00000059037
AA Change: C96R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000060100
Gene: ENSMUSG00000057143
AA Change: C96R

DomainStartEndE-ValueType
RING 15 58 5.51e-7 SMART
BBOX 91 132 4.83e-12 SMART
low complexity region 196 209 N/A INTRINSIC
Pfam:SPRY 351 493 8.7e-14 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000130139
AA Change: C96R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000116775
Gene: ENSMUSG00000057143
AA Change: C96R

DomainStartEndE-ValueType
RING 15 58 5.51e-7 SMART
BBOX 91 132 4.83e-12 SMART
low complexity region 196 209 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 24 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts6 A G 13: 104,390,135 I524V probably damaging Het
Atxn2 T A 5: 121,797,344 M336K probably damaging Het
Bcr T A 10: 75,154,951 F763Y probably damaging Het
Bdnf A G 2: 109,723,755 Y158C probably damaging Het
Ccdc92 T C 5: 124,835,856 E203G probably damaging Het
Cyp2j12 T C 4: 96,122,658 *72W probably null Het
Def6 G T 17: 28,223,727 R288L possibly damaging Het
Foxn1 T G 11: 78,360,906 S500R possibly damaging Het
Gss T C 2: 155,567,806 K77E probably damaging Het
Habp2 G A 19: 56,316,307 G410D probably benign Het
Krt36 A T 11: 100,104,120 C209S possibly damaging Het
Mmrn1 T C 6: 60,977,161 F809L probably benign Het
Mptx2 C A 1: 173,274,841 V94F probably damaging Het
Myh4 G T 11: 67,243,419 probably benign Het
N4bp2l1 G T 5: 150,594,316 H41N possibly damaging Het
Ndnf T A 6: 65,703,555 S273T probably benign Het
Nt5c1b A T 12: 10,390,108 Y624F possibly damaging Het
Prss8 C T 7: 127,926,580 V256M probably damaging Het
Ramp1 T C 1: 91,223,099 probably benign Het
Sf3b2 A G 19: 5,279,838 probably benign Het
Tfdp2 G A 9: 96,300,412 R235Q possibly damaging Het
Tle1 C T 4: 72,197,821 probably benign Het
Tmprss11e A G 5: 86,719,734 V159A probably damaging Het
Usp24 A G 4: 106,387,734 D1256G probably benign Het
Other mutations in Trim12c
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01612:Trim12c APN 7 104348215 missense possibly damaging 0.81
IGL01645:Trim12c APN 7 104345054 nonsense probably null
IGL02184:Trim12c APN 7 104348223 missense probably benign 0.00
IGL02309:Trim12c APN 7 104344956 missense possibly damaging 0.72
IGL02323:Trim12c APN 7 104348266 missense probably benign 0.00
IGL02656:Trim12c APN 7 104341203 missense probably damaging 1.00
R0127:Trim12c UTSW 7 104340906 splice site probably null
R0554:Trim12c UTSW 7 104344962 missense probably damaging 0.96
R1480:Trim12c UTSW 7 104348244 missense probably damaging 1.00
R1501:Trim12c UTSW 7 104340888 unclassified probably benign
R2058:Trim12c UTSW 7 104348191 missense possibly damaging 0.81
R2059:Trim12c UTSW 7 104348191 missense possibly damaging 0.81
R3838:Trim12c UTSW 7 104340868 unclassified probably benign
R3870:Trim12c UTSW 7 104348337 missense probably benign 0.00
R4896:Trim12c UTSW 7 104340948 missense probably damaging 0.99
R6288:Trim12c UTSW 7 104346729 missense probably benign 0.19
R6522:Trim12c UTSW 7 104348324 missense probably benign 0.38
R6562:Trim12c UTSW 7 104345134 splice site probably null
R6801:Trim12c UTSW 7 104348130 missense probably damaging 1.00
R7016:Trim12c UTSW 7 104348206 missense
R7811:Trim12c UTSW 7 104341262 missense unknown
R8076:Trim12c UTSW 7 104340830 missense unknown
R8147:Trim12c UTSW 7 104341958 missense unknown
X0062:Trim12c UTSW 7 104346680 missense probably benign 0.13
Z1176:Trim12c UTSW 7 104341136 missense unknown
Posted On2014-01-21