Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01738:Vmn2r17'

105751

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r17

Ensembl Gene

ENSMUSG00000091879

Gene Name

vomeronasal 2, receptor 17

Synonyms

EG384221

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.112) question?

Stock #

IGL01738

Quality Score

Status

Chromosome

Chromosomal Location

109567879-109601253 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 109577364 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glycine to Serine at position 472 (G472S)

Ref Sequence

ENSEMBL: ENSMUSP00000131450 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000171841]

AlphaFold

E9PYF5

Predicted Effect

probably damaging
Transcript: ENSMUST00000171841
AA Change: G472S

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000131450
Gene: ENSMUSG00000091879
AA Change: G472S

Domain	Start	End	E-Value	Type
signal peptide	1	24	N/A	INTRINSIC
Pfam:ANF_receptor	76	465	7e-26	PFAM
Pfam:NCD3G	508	562	3.5e-18	PFAM
Pfam:7tm_3	593	830	4.8e-55	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 32 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4933405L10Rik	A	T	8: 106,436,668 (GRCm39)	D288V	probably damaging	Het
Agtr1a	G	A	13: 30,565,021 (GRCm39)	V29I	probably benign	Het
Akap6	G	T	12: 52,933,600 (GRCm39)	C364F	probably damaging	Het
Calcrl	T	G	2: 84,200,793 (GRCm39)	M84L	probably benign	Het
Cep128	C	A	12: 91,197,616 (GRCm39)	G402C	probably damaging	Het
Cfap43	A	G	19: 47,785,624 (GRCm39)	L422P	probably damaging	Het
Cnbd2	C	A	2: 156,217,537 (GRCm39)		probably benign	Het
Col27a1	A	G	4: 63,182,016 (GRCm39)		probably benign	Het
Cyp3a44	A	G	5: 145,731,745 (GRCm39)	S134P	probably damaging	Het
Dync2h1	A	C	9: 7,114,922 (GRCm39)	L179R	possibly damaging	Het
Ell	T	A	8: 71,034,331 (GRCm39)		probably benign	Het
Gfm1	A	G	3: 67,363,994 (GRCm39)	E490G	probably benign	Het
Glt1d1	T	G	5: 127,709,419 (GRCm39)		probably benign	Het
Gm10267	A	T	18: 44,292,342 (GRCm39)	I10K	possibly damaging	Het
Htra4	A	G	8: 25,515,727 (GRCm39)	V437A	probably damaging	Het
Ighv1-69	T	C	12: 115,587,061 (GRCm39)	Q24R	possibly damaging	Het
Igkv14-111	G	A	6: 68,233,443 (GRCm39)		probably benign	Het
Ipcef1	A	T	10: 6,840,575 (GRCm39)	I374N	probably damaging	Het
Iqgap1	T	C	7: 80,373,648 (GRCm39)	D1447G	possibly damaging	Het
Mast4	A	G	13: 102,873,749 (GRCm39)	F1681S	probably damaging	Het
Mmp3	A	T	9: 7,446,946 (GRCm39)	N42I	possibly damaging	Het
Mybpc1	G	T	10: 88,406,507 (GRCm39)	F126L	probably damaging	Het
Myo1e	A	G	9: 70,266,652 (GRCm39)	K631E	probably damaging	Het
Or8b43	A	C	9: 38,360,942 (GRCm39)	Y258S	probably damaging	Het
Pcsk5	T	A	19: 17,411,144 (GRCm39)		probably benign	Het
Serpina3b	T	G	12: 104,097,091 (GRCm39)	L124R	probably damaging	Het
Srgap2	T	C	1: 131,224,164 (GRCm39)	I95V	probably benign	Het
Sstr5	A	T	17: 25,710,584 (GRCm39)	I215N	probably damaging	Het
Top3b	G	A	16: 16,698,468 (GRCm39)	V104M	probably benign	Het
Tspan8	G	A	10: 115,653,570 (GRCm39)		probably null	Het
Vmn2r102	A	G	17: 19,898,020 (GRCm39)	Y345C	probably damaging	Het
Zmpste24	A	T	4: 120,918,308 (GRCm39)	L438Q	probably damaging	Het

Other mutations in Vmn2r17

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00325:Vmn2r17	APN	5	109,575,858 (GRCm39)	missense	probably benign	0.15
IGL01457:Vmn2r17	APN	5	109,600,898 (GRCm39)	missense	probably benign	0.00
IGL01527:Vmn2r17	APN	5	109,601,006 (GRCm39)	missense	probably damaging	1.00
IGL01693:Vmn2r17	APN	5	109,600,384 (GRCm39)	missense	probably damaging	1.00
IGL01767:Vmn2r17	APN	5	109,567,903 (GRCm39)	missense	probably benign	0.01
IGL01932:Vmn2r17	APN	5	109,574,916 (GRCm39)	missense	probably benign	0.00
IGL01970:Vmn2r17	APN	5	109,575,813 (GRCm39)	missense	probably damaging	0.97
IGL02009:Vmn2r17	APN	5	109,600,714 (GRCm39)	missense	possibly damaging	0.67
IGL02365:Vmn2r17	APN	5	109,601,175 (GRCm39)	missense	probably damaging	1.00
IGL02385:Vmn2r17	APN	5	109,582,247 (GRCm39)	missense	probably damaging	1.00
IGL02457:Vmn2r17	APN	5	109,601,012 (GRCm39)	missense	probably damaging	1.00
IGL02646:Vmn2r17	APN	5	109,600,946 (GRCm39)	missense	probably damaging	1.00
IGL02741:Vmn2r17	APN	5	109,568,077 (GRCm39)	missense	probably benign
IGL03213:Vmn2r17	APN	5	109,582,256 (GRCm39)	critical splice donor site	probably null
IGL03216:Vmn2r17	APN	5	109,600,756 (GRCm39)	missense	probably damaging	1.00
IGL03342:Vmn2r17	APN	5	109,575,782 (GRCm39)	missense	probably damaging	1.00
IGL03408:Vmn2r17	APN	5	109,577,238 (GRCm39)	splice site	probably benign
R0349:Vmn2r17	UTSW	5	109,576,202 (GRCm39)	missense	probably damaging	1.00
R0418:Vmn2r17	UTSW	5	109,600,747 (GRCm39)	missense	probably damaging	1.00
R0800:Vmn2r17	UTSW	5	109,575,192 (GRCm39)	splice site	probably benign
R0836:Vmn2r17	UTSW	5	109,575,822 (GRCm39)	missense	possibly damaging	0.89
R1715:Vmn2r17	UTSW	5	109,576,110 (GRCm39)	missense	probably benign	0.00
R1738:Vmn2r17	UTSW	5	109,576,377 (GRCm39)	missense	probably benign	0.10
R1801:Vmn2r17	UTSW	5	109,576,344 (GRCm39)	missense	probably damaging	1.00
R2054:Vmn2r17	UTSW	5	109,600,352 (GRCm39)	missense	probably damaging	0.98
R2060:Vmn2r17	UTSW	5	109,575,075 (GRCm39)	missense	probably benign	0.00
R2192:Vmn2r17	UTSW	5	109,582,144 (GRCm39)	missense	possibly damaging	0.81
R2315:Vmn2r17	UTSW	5	109,575,897 (GRCm39)	missense	probably damaging	1.00
R2374:Vmn2r17	UTSW	5	109,575,104 (GRCm39)	missense	probably benign
R3612:Vmn2r17	UTSW	5	109,577,463 (GRCm39)	missense	probably benign	0.00
R3832:Vmn2r17	UTSW	5	109,576,262 (GRCm39)	missense	probably damaging	1.00
R4273:Vmn2r17	UTSW	5	109,600,832 (GRCm39)	missense	probably benign	0.44
R4494:Vmn2r17	UTSW	5	109,576,335 (GRCm39)	missense	probably damaging	1.00
R4597:Vmn2r17	UTSW	5	109,577,428 (GRCm39)	missense	probably benign	0.01
R4675:Vmn2r17	UTSW	5	109,575,049 (GRCm39)	missense	probably benign	0.00
R4701:Vmn2r17	UTSW	5	109,575,849 (GRCm39)	missense	probably damaging	0.99
R4754:Vmn2r17	UTSW	5	109,600,715 (GRCm39)	missense	probably damaging	0.99
R4841:Vmn2r17	UTSW	5	109,582,246 (GRCm39)	missense	probably damaging	1.00
R4842:Vmn2r17	UTSW	5	109,582,246 (GRCm39)	missense	probably damaging	1.00
R4865:Vmn2r17	UTSW	5	109,574,985 (GRCm39)	missense	probably damaging	1.00
R4902:Vmn2r17	UTSW	5	109,601,220 (GRCm39)	missense	probably benign	0.14
R4989:Vmn2r17	UTSW	5	109,575,739 (GRCm39)	missense	probably benign	0.07
R5101:Vmn2r17	UTSW	5	109,576,217 (GRCm39)	missense	probably damaging	0.99
R5109:Vmn2r17	UTSW	5	109,577,342 (GRCm39)	missense	probably benign	0.06
R5123:Vmn2r17	UTSW	5	109,575,774 (GRCm39)	missense	possibly damaging	0.90
R5474:Vmn2r17	UTSW	5	109,582,150 (GRCm39)	missense	probably damaging	1.00
R5485:Vmn2r17	UTSW	5	109,567,972 (GRCm39)	missense	probably benign	0.06
R5611:Vmn2r17	UTSW	5	109,576,030 (GRCm39)	missense	probably damaging	0.97
R5652:Vmn2r17	UTSW	5	109,577,430 (GRCm39)	missense	probably benign	0.10
R5717:Vmn2r17	UTSW	5	109,575,140 (GRCm39)	missense	possibly damaging	0.94
R5735:Vmn2r17	UTSW	5	109,600,716 (GRCm39)	missense	possibly damaging	0.67
R5766:Vmn2r17	UTSW	5	109,575,139 (GRCm39)	missense	possibly damaging	0.46
R6645:Vmn2r17	UTSW	5	109,576,247 (GRCm39)	missense	probably damaging	1.00
R6786:Vmn2r17	UTSW	5	109,575,695 (GRCm39)	missense	probably benign	0.30
R6821:Vmn2r17	UTSW	5	109,577,331 (GRCm39)	missense	probably damaging	1.00
R6979:Vmn2r17	UTSW	5	109,576,265 (GRCm39)	missense	possibly damaging	0.46
R6984:Vmn2r17	UTSW	5	109,600,533 (GRCm39)	missense	probably benign	0.10
R7269:Vmn2r17	UTSW	5	109,576,337 (GRCm39)	missense	possibly damaging	0.88
R7509:Vmn2r17	UTSW	5	109,575,695 (GRCm39)	missense	probably benign	0.30
R7736:Vmn2r17	UTSW	5	109,600,757 (GRCm39)	missense	probably benign	0.05
R7789:Vmn2r17	UTSW	5	109,600,831 (GRCm39)	missense	possibly damaging	0.77
R7814:Vmn2r17	UTSW	5	109,575,739 (GRCm39)	missense	probably benign	0.07
R7847:Vmn2r17	UTSW	5	109,568,063 (GRCm39)	missense	probably damaging	1.00
R7863:Vmn2r17	UTSW	5	109,568,035 (GRCm39)	missense	probably benign
R7893:Vmn2r17	UTSW	5	109,575,944 (GRCm39)	missense	probably benign	0.05
R8234:Vmn2r17	UTSW	5	109,601,235 (GRCm39)	missense	probably benign	0.01
R8382:Vmn2r17	UTSW	5	109,576,387 (GRCm39)	missense	probably benign	0.01
R8435:Vmn2r17	UTSW	5	109,576,172 (GRCm39)	missense	probably benign	0.01
R8465:Vmn2r17	UTSW	5	109,600,691 (GRCm39)	missense	probably damaging	0.99
R8555:Vmn2r17	UTSW	5	109,600,810 (GRCm39)	missense	probably damaging	0.99
R8900:Vmn2r17	UTSW	5	109,575,863 (GRCm39)	missense	probably benign	0.25
R9293:Vmn2r17	UTSW	5	109,600,712 (GRCm39)	missense	probably damaging	1.00
R9308:Vmn2r17	UTSW	5	109,600,505 (GRCm39)	missense	probably damaging	0.98
R9378:Vmn2r17	UTSW	5	109,575,732 (GRCm39)	missense	possibly damaging	0.94
R9597:Vmn2r17	UTSW	5	109,575,669 (GRCm39)	missense	probably damaging	1.00

Posted On

2014-01-21