Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01739:Mos'

105821

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Mos

Ensembl Gene

ENSMUSG00000078365

Gene Name

Moloney sarcoma oncogene

Synonyms

c-mos

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL01739

Quality Score

Status

Chromosome

Chromosomal Location

3870658-3872105 bp(-) (GRCm39)

Type of Mutation

utr 5 prime

DNA Base Change (assembly)

A to G at 3871816 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000100789 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000105158]

AlphaFold

P00536

Predicted Effect

probably benign
Transcript: ENSMUST00000105158

SMART Domains

Protein: ENSMUSP00000100789
Gene: ENSMUSG00000078365

Domain	Start	End	E-Value	Type
low complexity region	39	54	N/A	INTRINSIC
Pfam:Pkinase_Tyr	63	335	9e-41	PFAM
Pfam:Pkinase	64	334	6.3e-43	PFAM

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] MOS is a serine/threonine kinase that activates the MAP kinase cascade through direct phosphorylation of the MAP kinase activator MEK (MAP2K1; MIM 176872) (Prasad et al., 2008 [PubMed 18246541]).[supplied by OMIM, Jul 2009]
PHENOTYPE: Mutations that inactivate the gene result in female infertility and an increased susceptibility to tumors. Oocytes progress through meiosis II without arrest and undergo spontaneous parthenogenetic activation. Male mice are fertile and show no spermatogenic defects. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 42 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acp4	G	T	7: 43,906,210 (GRCm39)	Y88*	probably null	Het
Aftph	T	C	11: 20,676,994 (GRCm39)	D205G	probably damaging	Het
Arhgap31	T	C	16: 38,423,793 (GRCm39)	I758V	probably benign	Het
Atg9b	A	G	5: 24,591,513 (GRCm39)		probably null	Het
Auts2	T	C	5: 131,469,056 (GRCm39)	T754A	probably benign	Het
Birc6	A	G	17: 74,966,216 (GRCm39)	M4048V	probably benign	Het
Cacna1s	T	C	1: 136,024,870 (GRCm39)		probably null	Het
Cmpk1	C	T	4: 114,822,121 (GRCm39)	A143T	probably benign	Het
Cstf2t	C	A	19: 31,060,536 (GRCm39)	P24Q	probably damaging	Het
Cwc22	A	G	2: 77,757,640 (GRCm39)	S163P	probably damaging	Het
Dnaaf11	T	A	15: 66,321,326 (GRCm39)	M272L	probably benign	Het
Faf1	T	A	4: 109,534,278 (GRCm39)		probably benign	Het
Focad	T	A	4: 88,289,043 (GRCm39)	I1279N	unknown	Het
Gp5	T	C	16: 30,127,459 (GRCm39)	D405G	possibly damaging	Het
Guf1	C	A	5: 69,718,501 (GRCm39)	N213K	probably damaging	Het
Hacd4	T	C	4: 88,341,285 (GRCm39)	T145A	probably damaging	Het
Itga11	T	C	9: 62,681,399 (GRCm39)	M1005T	probably benign	Het
Mast4	T	A	13: 102,910,781 (GRCm39)	T621S	probably damaging	Het
Mme	T	C	3: 63,247,534 (GRCm39)	M273T	possibly damaging	Het
Msln	C	T	17: 25,969,004 (GRCm39)		probably null	Het
Mtg1	A	T	7: 139,730,149 (GRCm39)	Q315L	probably benign	Het
Myh1	A	G	11: 67,105,354 (GRCm39)	E1048G	probably damaging	Het
Ndufa9	C	T	6: 126,821,777 (GRCm39)	G66D	probably damaging	Het
Nr1i2	T	C	16: 38,086,333 (GRCm39)	K44R	probably benign	Het
Nup155	T	A	15: 8,165,272 (GRCm39)	M636K	probably benign	Het
Or12d12	A	T	17: 37,610,673 (GRCm39)	F213L	probably benign	Het
Or5b96	T	A	19: 12,867,513 (GRCm39)	T143S	probably benign	Het
Pde4b	A	T	4: 102,458,832 (GRCm39)	Q496L	probably damaging	Het
Plekha6	T	C	1: 133,187,869 (GRCm39)	V130A	probably benign	Het
Prag1	A	G	8: 36,569,834 (GRCm39)	N139S	probably benign	Het
Rbpj-ps3	T	C	6: 46,507,694 (GRCm39)	T19A	probably benign	Het
Scai	A	G	2: 38,984,803 (GRCm39)		probably benign	Het
Slc12a7	A	G	13: 73,947,733 (GRCm39)	T617A	probably benign	Het
Slc15a2	T	C	16: 36,576,592 (GRCm39)	M481V	probably benign	Het
Snx5	A	G	2: 144,112,325 (GRCm39)	L8P	probably benign	Het
Spg11	C	T	2: 121,945,152 (GRCm39)	A123T	probably damaging	Het
Supt6	T	A	11: 78,113,013 (GRCm39)	I977F	probably damaging	Het
Tjp3	T	C	10: 81,114,490 (GRCm39)	D442G	probably benign	Het
Ttc21b	A	T	2: 66,068,200 (GRCm39)	N275K	probably benign	Het
Vmn2r50	A	G	7: 9,771,364 (GRCm39)	F779S	probably damaging	Het
Xirp2	A	T	2: 67,345,482 (GRCm39)	R2574S	probably benign	Het
Zbp1	T	C	2: 173,054,038 (GRCm39)	E161G	possibly damaging	Het

Other mutations in Mos

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00848:Mos	APN	4	3,871,459 (GRCm39)	missense	probably damaging	1.00
IGL01302:Mos	APN	4	3,871,815 (GRCm39)	utr 5 prime	probably benign
IGL01867:Mos	APN	4	3,870,845 (GRCm39)	missense	probably benign	0.33
IGL02647:Mos	APN	4	3,870,961 (GRCm39)	missense	probably damaging	1.00
PIT4418001:Mos	UTSW	4	3,870,814 (GRCm39)	missense	possibly damaging	0.86
R0967:Mos	UTSW	4	3,870,932 (GRCm39)	missense	probably benign
R4927:Mos	UTSW	4	3,871,093 (GRCm39)	missense	probably damaging	1.00
R5729:Mos	UTSW	4	3,870,971 (GRCm39)	missense	probably benign	0.01
R6947:Mos	UTSW	4	3,871,585 (GRCm39)	missense	probably damaging	1.00
R8359:Mos	UTSW	4	3,871,097 (GRCm39)	missense	probably damaging	1.00
R8526:Mos	UTSW	4	3,871,709 (GRCm39)	missense	probably damaging	0.99
R9106:Mos	UTSW	4	3,871,457 (GRCm39)	missense	probably benign	0.44
R9336:Mos	UTSW	4	3,870,886 (GRCm39)	missense	probably damaging	1.00
R9347:Mos	UTSW	4	3,871,763 (GRCm39)	missense	probably benign	0.02
R9683:Mos	UTSW	4	3,871,186 (GRCm39)	missense	probably benign	0.02

Posted On

2014-01-21