Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00686:Fam135b'

10627

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Fam135b

Ensembl Gene

ENSMUSG00000036800

Gene Name

family with sequence similarity 135, member B

Synonyms

1700010C24Rik, A830008O07Rik

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL00686

Quality Score

Status

Chromosome

Chromosomal Location

71431609-71727838 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 71462319 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Serine to Proline at position 1009 (S1009P)

Ref Sequence

ENSEMBL: ENSMUSP00000022953 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000022953]

AlphaFold

Q9DAI6

Predicted Effect

probably benign
Transcript: ENSMUST00000022953
AA Change: S1009P

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)

SMART Domains

Protein: ENSMUSP00000022953
Gene: ENSMUSG00000036800
AA Change: S1009P

Domain	Start	End	E-Value	Type
Pfam:DUF3657	111	172	1.9e-19	PFAM
low complexity region	744	757	N/A	INTRINSIC
low complexity region	1124	1130	N/A	INTRINSIC
Pfam:DUF676	1132	1328	2.7e-60	PFAM
Pfam:PGAP1	1135	1309	3.2e-9	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000229634

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 6 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4932438H23Rik	A	G	16: 91,055,601 (GRCm38)	S216P	possibly damaging	Het
Btk	A	G	X: 134,559,264 (GRCm38)	Y152H	probably damaging	Het
Casp8ap2	A	G	4: 32,641,433 (GRCm38)	D829G	probably damaging	Het
Fam57b	C	T	7: 126,825,003 (GRCm38)		probably benign	Het
Glt8d2	T	A	10: 82,651,513 (GRCm38)	N298Y	possibly damaging	Het
Samt4	C	T	X: 154,484,132 (GRCm38)	T89I	probably benign	Het

Other mutations in Fam135b

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00088:Fam135b	APN	15	71,450,494 (GRCm38)	missense	probably damaging	1.00
IGL00565:Fam135b	APN	15	71,471,512 (GRCm38)	missense	probably benign
IGL00645:Fam135b	APN	15	71,462,546 (GRCm38)	missense	probably damaging	1.00
IGL00857:Fam135b	APN	15	71,463,616 (GRCm38)	missense	probably benign	0.16
IGL01443:Fam135b	APN	15	71,463,364 (GRCm38)	missense	probably benign	0.02
IGL01690:Fam135b	APN	15	71,456,935 (GRCm38)	missense	probably benign	0.19
IGL01920:Fam135b	APN	15	71,622,036 (GRCm38)	missense	possibly damaging	0.94
IGL01987:Fam135b	APN	15	71,462,115 (GRCm38)	missense	probably benign
IGL02154:Fam135b	APN	15	71,448,710 (GRCm38)	missense	probably benign	0.12
IGL03107:Fam135b	APN	15	71,463,561 (GRCm38)	missense	probably benign
IGL03264:Fam135b	APN	15	71,462,788 (GRCm38)	missense	probably benign
IGL03055:Fam135b	UTSW	15	71,622,034 (GRCm38)	missense	possibly damaging	0.51
R0010:Fam135b	UTSW	15	71,622,032 (GRCm38)	missense	probably damaging	1.00
R0010:Fam135b	UTSW	15	71,622,032 (GRCm38)	missense	probably damaging	1.00
R0230:Fam135b	UTSW	15	71,446,037 (GRCm38)	missense	probably benign	0.02
R0413:Fam135b	UTSW	15	71,463,821 (GRCm38)	missense	probably benign	0.45
R0524:Fam135b	UTSW	15	71,462,284 (GRCm38)	missense	probably benign	0.00
R0565:Fam135b	UTSW	15	71,490,837 (GRCm38)	missense	possibly damaging	0.88
R0628:Fam135b	UTSW	15	71,448,656 (GRCm38)	splice site	probably benign
R1415:Fam135b	UTSW	15	71,456,928 (GRCm38)	missense	probably damaging	0.99
R1462:Fam135b	UTSW	15	71,621,996 (GRCm38)	splice site	probably benign
R1701:Fam135b	UTSW	15	71,459,729 (GRCm38)	missense	probably damaging	1.00
R1797:Fam135b	UTSW	15	71,452,441 (GRCm38)	missense	probably benign	0.41
R1807:Fam135b	UTSW	15	71,463,912 (GRCm38)	missense	probably benign
R1835:Fam135b	UTSW	15	71,490,711 (GRCm38)	missense	probably damaging	1.00
R1905:Fam135b	UTSW	15	71,532,987 (GRCm38)	missense	probably damaging	1.00
R1937:Fam135b	UTSW	15	71,622,014 (GRCm38)	missense	probably damaging	1.00
R1998:Fam135b	UTSW	15	71,452,404 (GRCm38)	missense	probably damaging	0.98
R2076:Fam135b	UTSW	15	71,478,243 (GRCm38)	missense	probably damaging	0.99
R2518:Fam135b	UTSW	15	71,463,911 (GRCm38)	missense	probably benign	0.00
R3110:Fam135b	UTSW	15	71,464,030 (GRCm38)	missense	probably benign	0.05
R3112:Fam135b	UTSW	15	71,464,030 (GRCm38)	missense	probably benign	0.05
R3932:Fam135b	UTSW	15	71,450,431 (GRCm38)	missense	probably benign	0.29
R4361:Fam135b	UTSW	15	71,490,827 (GRCm38)	missense	probably damaging	1.00
R4397:Fam135b	UTSW	15	71,448,676 (GRCm38)	missense	probably benign	0.17
R4435:Fam135b	UTSW	15	71,448,739 (GRCm38)	missense	probably damaging	1.00
R4645:Fam135b	UTSW	15	71,462,340 (GRCm38)	missense	probably benign
R4740:Fam135b	UTSW	15	71,464,071 (GRCm38)	missense	probably benign	0.01
R4748:Fam135b	UTSW	15	71,464,055 (GRCm38)	missense	probably benign	0.00
R4754:Fam135b	UTSW	15	71,462,951 (GRCm38)	missense	probably benign	0.01
R5044:Fam135b	UTSW	15	71,462,711 (GRCm38)	missense	probably benign	0.02
R5469:Fam135b	UTSW	15	71,446,043 (GRCm38)	missense	probably benign	0.16
R5617:Fam135b	UTSW	15	71,622,016 (GRCm38)	missense	probably damaging	1.00
R5642:Fam135b	UTSW	15	71,462,136 (GRCm38)	missense	probably damaging	1.00
R5778:Fam135b	UTSW	15	71,479,032 (GRCm38)	missense	probably damaging	1.00
R5891:Fam135b	UTSW	15	71,525,803 (GRCm38)	missense	probably damaging	1.00
R5958:Fam135b	UTSW	15	71,462,895 (GRCm38)	missense
R5982:Fam135b	UTSW	15	71,448,669 (GRCm38)	critical splice donor site	probably null
R5987:Fam135b	UTSW	15	71,490,848 (GRCm38)	missense	probably benign	0.00
R6535:Fam135b	UTSW	15	71,622,075 (GRCm38)	missense	probably damaging	0.99
R6734:Fam135b	UTSW	15	71,462,780 (GRCm38)	missense	probably benign	0.02
R6887:Fam135b	UTSW	15	71,463,315 (GRCm38)	missense	probably damaging	1.00
R7028:Fam135b	UTSW	15	71,471,563 (GRCm38)	missense	probably damaging	1.00
R7035:Fam135b	UTSW	15	71,462,253 (GRCm38)	missense	possibly damaging	0.77
R7097:Fam135b	UTSW	15	71,622,068 (GRCm38)	missense	possibly damaging	0.92
R7143:Fam135b	UTSW	15	71,479,151 (GRCm38)	missense	probably benign	0.44
R7414:Fam135b	UTSW	15	71,478,256 (GRCm38)	missense	probably damaging	0.97
R7439:Fam135b	UTSW	15	71,463,680 (GRCm38)	missense	probably damaging	0.98
R7441:Fam135b	UTSW	15	71,463,680 (GRCm38)	missense	probably damaging	0.98
R7545:Fam135b	UTSW	15	71,450,510 (GRCm38)	missense	possibly damaging	0.95
R7615:Fam135b	UTSW	15	71,463,323 (GRCm38)	missense	probably damaging	1.00
R7642:Fam135b	UTSW	15	71,479,142 (GRCm38)	missense	possibly damaging	0.51
R7649:Fam135b	UTSW	15	71,462,580 (GRCm38)	missense	probably benign	0.00
R7686:Fam135b	UTSW	15	71,463,384 (GRCm38)	missense	possibly damaging	0.68
R7866:Fam135b	UTSW	15	71,462,076 (GRCm38)	missense	probably benign	0.00
R8006:Fam135b	UTSW	15	71,462,334 (GRCm38)	missense	probably benign	0.00
R8068:Fam135b	UTSW	15	71,532,978 (GRCm38)	missense	probably damaging	1.00
R8167:Fam135b	UTSW	15	71,532,991 (GRCm38)	missense	probably null	1.00
R8252:Fam135b	UTSW	15	71,533,023 (GRCm38)	missense	probably benign	0.10
R8548:Fam135b	UTSW	15	71,462,810 (GRCm38)	missense	probably damaging	0.99
R8833:Fam135b	UTSW	15	71,462,934 (GRCm38)	missense	probably benign	0.04
R8955:Fam135b	UTSW	15	71,462,214 (GRCm38)	missense	possibly damaging	0.85
R8961:Fam135b	UTSW	15	71,532,963 (GRCm38)	missense	probably damaging	1.00
R8987:Fam135b	UTSW	15	71,462,340 (GRCm38)	missense	probably benign	0.00
R9149:Fam135b	UTSW	15	71,462,895 (GRCm38)	missense
R9161:Fam135b	UTSW	15	71,462,568 (GRCm38)	missense	possibly damaging	0.91
R9227:Fam135b	UTSW	15	71,464,007 (GRCm38)	missense	probably benign	0.28
R9230:Fam135b	UTSW	15	71,464,007 (GRCm38)	missense	probably benign	0.28
R9365:Fam135b	UTSW	15	71,462,964 (GRCm38)	missense	probably benign	0.00
R9622:Fam135b	UTSW	15	71,525,837 (GRCm38)	missense	probably damaging	0.98
R9758:Fam135b	UTSW	15	71,452,350 (GRCm38)	missense	probably benign	0.28
R9759:Fam135b	UTSW	15	71,463,840 (GRCm38)	missense	probably benign	0.44
T0722:Fam135b	UTSW	15	71,463,885 (GRCm38)	missense	probably damaging	1.00
T0975:Fam135b	UTSW	15	71,463,885 (GRCm38)	missense	probably damaging	1.00
Z1177:Fam135b	UTSW	15	71,622,076 (GRCm38)	start codon destroyed	probably null	0.06

Posted On

2012-12-06