Incidental Mutation 'IGL00799:Fam151b'
ID10637
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Fam151b
Ensembl Gene ENSMUSG00000034334
Gene Namefamily with sequence similarity 151, member B
Synonyms4930405M20Rik
Accession Numbers

NCBI RefSeq: NM_001163627.1; MGI:1921192

Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL00799
Quality Score
Status
Chromosome13
Chromosomal Location92449625-92484015 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to A at 92477853 bp
ZygosityHeterozygous
Amino Acid Change Lysine to Asparagine at position 42 (K42N)
Ref Sequence ENSEMBL: ENSMUSP00000153204 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000040106] [ENSMUST00000225299]
Predicted Effect possibly damaging
Transcript: ENSMUST00000040106
AA Change: K42N

PolyPhen 2 Score 0.786 (Sensitivity: 0.85; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000045024
Gene: ENSMUSG00000034334
AA Change: K42N

DomainStartEndE-ValueType
Pfam:DUF2181 29 263 2.3e-102 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000225299
AA Change: K42N

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Coding Region Coverage
Validation Efficiency
Allele List at MGI

All alleles(2) : Targeted(2)

Other mutations in this stock
Total: 19 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
AI314180 T A 4: 58,828,047 I981F possibly damaging Het
Boc G T 16: 44,492,955 D515E probably benign Het
Cenpe T A 3: 135,228,917 probably null Het
Ctcf A G 8: 105,677,336 D608G unknown Het
Dab2ip A G 2: 35,707,775 I99V probably benign Het
Ehd2 C T 7: 15,963,467 A139T possibly damaging Het
Gapvd1 A T 2: 34,699,860 D1002E probably benign Het
Gm13124 A T 4: 144,555,273 H316Q probably benign Het
Gusb T C 5: 129,999,381 Y290C probably damaging Het
Hoxd10 A G 2: 74,692,442 S155G probably benign Het
Hp A G 8: 109,575,618 probably null Het
Ift122 T C 6: 115,877,536 S112P probably damaging Het
Iqgap2 A G 13: 95,657,944 probably benign Het
Mtbp T A 15: 55,617,508 L290* probably null Het
Nr5a2 T A 1: 136,890,798 D330V probably damaging Het
R3hdm1 T A 1: 128,174,963 L157Q probably damaging Het
Rad21 A T 15: 51,976,125 D116E possibly damaging Het
Slc23a3 A T 1: 75,133,281 I114N possibly damaging Het
Syne1 A G 10: 5,347,878 I1140L probably benign Het
Other mutations in Fam151b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02253:Fam151b APN 13 92477927 missense probably damaging 1.00
IGL03084:Fam151b APN 13 92468026 missense probably damaging 0.97
IGL03130:Fam151b APN 13 92450193 missense probably benign 0.01
P0015:Fam151b UTSW 13 92467944 critical splice donor site probably null
R0067:Fam151b UTSW 13 92473996 missense probably benign 0.08
R0067:Fam151b UTSW 13 92473996 missense probably benign 0.08
R0348:Fam151b UTSW 13 92450181 missense probably benign 0.00
R1404:Fam151b UTSW 13 92473972 missense probably damaging 1.00
R1404:Fam151b UTSW 13 92473972 missense probably damaging 1.00
R1482:Fam151b UTSW 13 92450166 missense probably benign 0.03
R1837:Fam151b UTSW 13 92474131 intron probably benign
R1891:Fam151b UTSW 13 92450170 missense probably benign 0.00
R1957:Fam151b UTSW 13 92477902 missense probably damaging 1.00
R1957:Fam151b UTSW 13 92477903 missense probably damaging 1.00
R2175:Fam151b UTSW 13 92477918 missense probably damaging 0.99
R4583:Fam151b UTSW 13 92468109 missense probably damaging 1.00
R6762:Fam151b UTSW 13 92468050 missense possibly damaging 0.79
R8153:Fam151b UTSW 13 92477902 missense probably damaging 1.00
X0021:Fam151b UTSW 13 92450226 missense probably benign 0.06
Posted On2012-12-06