Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL00767:Mindy2'

10668

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Mindy2

Ensembl Gene

ENSMUSG00000042444

Gene Name

MINDY lysine 48 deubiquitinase 2

Synonyms

B230380D07Rik, Fam63b

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.129) question?

Stock #

IGL00767

Quality Score

Status

Chromosome

Chromosomal Location

70599014-70657174 bp(-) (GRCm38)

Type of Mutation

critical splice donor site (2 bp from exon)

DNA Base Change (assembly)

A to G at 70634003 bp

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000150300 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000049031] [ENSMUST00000213380]

Predicted Effect

probably null
Transcript: ENSMUST00000049031

SMART Domains

Protein: ENSMUSP00000037035
Gene: ENSMUSG00000042444

Domain	Start	End	E-Value	Type
low complexity region	22	41	N/A	INTRINSIC
low complexity region	79	86	N/A	INTRINSIC
low complexity region	126	173	N/A	INTRINSIC
low complexity region	186	195	N/A	INTRINSIC
Pfam:DUF544	250	373	6.9e-42	PFAM
low complexity region	498	508	N/A	INTRINSIC
low complexity region	535	570	N/A	INTRINSIC
low complexity region	578	595	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000213380

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000214293

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 20 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2810474O19Rik	T	C	6: 149,334,750		probably benign	Het
Anpep	A	C	7: 79,840,890	S293A	probably benign	Het
Dgkh	T	A	14: 78,587,261		probably benign	Het
Dlg5	T	A	14: 24,165,285	T657S	probably damaging	Het
Hpf1	A	G	8: 60,896,802	I155V	probably benign	Het
Il12rb2	T	C	6: 67,303,562	I554V	possibly damaging	Het
Nostrin	A	G	2: 69,175,775	T268A	probably benign	Het
Npy6r	A	G	18: 44,276,318	T269A	probably benign	Het
Nt5dc3	T	A	10: 86,820,273		probably benign	Het
Osgin2	G	A	4: 16,006,377	H106Y	probably damaging	Het
Pdlim3	G	A	8: 45,896,790	G46R	probably damaging	Het
Pdpk1	T	G	17: 24,106,861	K147N	possibly damaging	Het
Pfkfb3	T	C	2: 11,488,754	D137G	probably damaging	Het
Polg	G	A	7: 79,451,925	P1048S	probably damaging	Het
Ptcd3	A	T	6: 71,903,448	I97K	probably damaging	Het
Serpinb10	G	T	1: 107,536,077	V30F	possibly damaging	Het
Stk17b	A	G	1: 53,764,023		probably benign	Het
Tll1	G	A	8: 64,071,321	R444C	probably damaging	Het
Ttbk2	A	G	2: 120,745,745	V848A	probably benign	Het
Ttn	T	C	2: 76,885,673		probably benign	Het

Other mutations in Mindy2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00770:Mindy2	APN	9	70631033	missense	probably benign	0.05
IGL00774:Mindy2	APN	9	70631033	missense	probably benign	0.05
IGL01889:Mindy2	APN	9	70631162	splice site	probably benign
IGL02860:Mindy2	APN	9	70656544	missense	probably damaging	1.00
R0100:Mindy2	UTSW	9	70607449	splice site	probably benign
R0563:Mindy2	UTSW	9	70631052	missense	possibly damaging	0.77
R1109:Mindy2	UTSW	9	70631079	nonsense	probably null
R1446:Mindy2	UTSW	9	70607456	critical splice donor site	probably null
R1736:Mindy2	UTSW	9	70631030	missense	probably damaging	1.00
R2156:Mindy2	UTSW	9	70656592	missense	probably benign	0.01
R4091:Mindy2	UTSW	9	70634060	missense	probably damaging	0.98
R4290:Mindy2	UTSW	9	70631094	missense	probably damaging	1.00
R4626:Mindy2	UTSW	9	70626781	missense	probably damaging	1.00
R4791:Mindy2	UTSW	9	70634001	splice site	probably null
R4973:Mindy2	UTSW	9	70605171	missense	possibly damaging	0.86
R6077:Mindy2	UTSW	9	70631081	missense	probably damaging	1.00
R6237:Mindy2	UTSW	9	70605198	missense	possibly damaging	0.72
R6872:Mindy2	UTSW	9	70616762	critical splice donor site	probably null
R7307:Mindy2	UTSW	9	70610959	missense	possibly damaging	0.89
R7521:Mindy2	UTSW	9	70607510	missense	probably benign	0.18
R7638:Mindy2	UTSW	9	70616859	missense	probably damaging	1.00

Posted On

2012-12-06