Incidental Mutation 'IGL00823:Tmem255b'
ID 10672
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tmem255b
Ensembl Gene ENSMUSG00000038457
Gene Name transmembrane protein 255B
Synonyms Fam70b, LOC272465
Accession Numbers
Essential gene? Probably non essential (E-score: 0.057) question?
Stock # IGL00823
Quality Score
Status
Chromosome 8
Chromosomal Location 13485189-13518473 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 13507054 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Threonine at position 261 (M261T)
Ref Sequence ENSEMBL: ENSMUSP00000130504 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000167071] [ENSMUST00000167505] [ENSMUST00000210804]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000167071
AA Change: M240T

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000127421
Gene: ENSMUSG00000038457
AA Change: M240T

DomainStartEndE-ValueType
Pfam:FAM70 1 68 8.2e-28 PFAM
Pfam:FAM70 66 307 1.8e-119 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000167505
AA Change: M261T

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000130504
Gene: ENSMUSG00000038457
AA Change: M261T

DomainStartEndE-ValueType
Pfam:FAM70 6 328 6e-166 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000209950
Predicted Effect probably benign
Transcript: ENSMUST00000210804
Predicted Effect noncoding transcript
Transcript: ENSMUST00000211356
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aasdh T C 5: 77,026,381 (GRCm39) probably benign Het
Adam5 T C 8: 25,308,758 (GRCm39) E39G probably benign Het
Anapc7 G A 5: 122,571,540 (GRCm39) W205* probably null Het
Arhgap5 C T 12: 52,565,525 (GRCm39) T832I possibly damaging Het
Arhgef10 T A 8: 14,990,378 (GRCm39) probably benign Het
Atg5 A G 10: 44,239,040 (GRCm39) T274A probably benign Het
Baiap2l2 G T 15: 79,168,765 (GRCm39) probably benign Het
Brap T A 5: 121,803,290 (GRCm39) M146K probably damaging Het
Brpf1 T C 6: 113,298,847 (GRCm39) S1074P probably benign Het
Camta1 A C 4: 151,169,058 (GRCm39) I231R probably benign Het
Ccdc15 C T 9: 37,231,709 (GRCm39) G205D probably benign Het
Cd6 G T 19: 10,773,758 (GRCm39) probably benign Het
Cdh17 T G 4: 11,783,412 (GRCm39) S219R possibly damaging Het
Cgn G A 3: 94,674,519 (GRCm39) R873W probably damaging Het
Ctnna3 C T 10: 63,373,322 (GRCm39) P41L possibly damaging Het
Dmbt1 T C 7: 130,659,888 (GRCm39) W484R probably benign Het
Dmd A G X: 83,469,419 (GRCm39) probably null Het
Dnah17 C T 11: 117,937,987 (GRCm39) V3347I probably benign Het
Fgd5 T A 6: 91,965,440 (GRCm39) S400T possibly damaging Het
Kitl C A 10: 99,923,206 (GRCm39) probably benign Het
Lamc3 A T 2: 31,808,533 (GRCm39) D763V probably damaging Het
Lgmn T C 12: 102,364,435 (GRCm39) probably benign Het
Lpcat2 T G 8: 93,591,598 (GRCm39) W81G possibly damaging Het
Myh13 A G 11: 67,246,773 (GRCm39) I1165V probably benign Het
Nf1 A G 11: 79,456,343 (GRCm39) D599G probably damaging Het
Nin T C 12: 70,061,567 (GRCm39) N2099S probably benign Het
Nlrc4 T C 17: 74,754,985 (GRCm39) D77G probably benign Het
Otub1 A G 19: 7,181,416 (GRCm39) probably benign Het
Pabir2 A T X: 52,334,208 (GRCm39) C222S probably damaging Het
Pah A G 10: 87,406,193 (GRCm39) Y174C probably null Het
Rbbp5 G A 1: 132,417,444 (GRCm39) V88I probably damaging Het
Scn1a C T 2: 66,155,279 (GRCm39) R560H probably benign Het
Snx5 T C 2: 144,097,485 (GRCm39) I217V probably benign Het
Syne2 T C 12: 76,036,016 (GRCm39) S3769P probably damaging Het
Tent2 T C 13: 93,322,905 (GRCm39) T15A probably benign Het
Top3b T C 16: 16,705,486 (GRCm39) I417T probably damaging Het
Tspan2 T C 3: 102,665,549 (GRCm39) probably null Het
Ttn T C 2: 76,540,057 (GRCm39) T34310A possibly damaging Het
Ush2a G A 1: 188,643,640 (GRCm39) C4334Y possibly damaging Het
Wdpcp A G 11: 21,609,995 (GRCm39) D21G probably damaging Het
Yy2 A C X: 156,351,207 (GRCm39) D186E probably benign Het
Other mutations in Tmem255b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02635:Tmem255b APN 8 13,505,195 (GRCm39) missense probably damaging 1.00
IGL02679:Tmem255b APN 8 13,507,055 (GRCm39) missense probably benign 0.04
IGL02945:Tmem255b APN 8 13,505,141 (GRCm39) missense probably damaging 0.98
IGL03007:Tmem255b APN 8 13,507,066 (GRCm39) missense possibly damaging 0.94
IGL03146:Tmem255b APN 8 13,504,174 (GRCm39) missense probably damaging 1.00
R2278:Tmem255b UTSW 8 13,501,081 (GRCm39) missense probably damaging 1.00
R2410:Tmem255b UTSW 8 13,491,278 (GRCm39) missense probably benign 0.22
R3081:Tmem255b UTSW 8 13,501,048 (GRCm39) missense probably damaging 0.99
R4498:Tmem255b UTSW 8 13,505,998 (GRCm39) missense probably damaging 1.00
R4612:Tmem255b UTSW 8 13,504,228 (GRCm39) missense probably benign 0.00
R6018:Tmem255b UTSW 8 13,505,138 (GRCm39) missense probably benign 0.00
R6073:Tmem255b UTSW 8 13,506,958 (GRCm39) missense probably damaging 0.98
R6240:Tmem255b UTSW 8 13,504,216 (GRCm39) missense probably damaging 1.00
R6737:Tmem255b UTSW 8 13,507,096 (GRCm39) critical splice donor site probably null
R8231:Tmem255b UTSW 8 13,504,225 (GRCm39) missense probably damaging 0.97
R9653:Tmem255b UTSW 8 13,506,005 (GRCm39) missense probably damaging 1.00
Posted On 2012-12-06