Incidental Mutation 'IGL00715:Fmo2'
ID10788
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Fmo2
Ensembl Gene ENSMUSG00000040170
Gene Nameflavin containing monooxygenase 2
Synonyms2310008D08Rik, 2310042I22Rik
Accession Numbers

Genbank: NM_018881

Is this an essential gene? Probably non essential (E-score: 0.065) question?
Stock #IGL00715
Quality Score
Status
Chromosome1
Chromosomal Location162874317-162898726 bp(-) (GRCm38)
Type of Mutationnonsense
DNA Base Change (assembly) T to A at 162888713 bp
ZygosityHeterozygous
Amino Acid Change Lysine to Stop codon at position 102 (K102*)
Ref Sequence ENSEMBL: ENSMUSP00000114226 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000045902] [ENSMUST00000111510] [ENSMUST00000143123]
Predicted Effect probably null
Transcript: ENSMUST00000045902
AA Change: K102*
SMART Domains Protein: ENSMUSP00000044405
Gene: ENSMUSG00000040170
AA Change: K102*

DomainStartEndE-ValueType
Pfam:FMO-like 2 533 8.7e-296 PFAM
Pfam:Pyr_redox_2 3 230 6.4e-12 PFAM
Pfam:Pyr_redox_3 6 220 4.4e-10 PFAM
Pfam:K_oxygenase 69 233 2.2e-11 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000111510
AA Change: K102*
SMART Domains Protein: ENSMUSP00000107135
Gene: ENSMUSG00000040170
AA Change: K102*

DomainStartEndE-ValueType
Pfam:FMO-like 2 533 8.7e-296 PFAM
Pfam:Pyr_redox_2 4 446 1.3e-6 PFAM
Pfam:Pyr_redox_3 6 220 8e-17 PFAM
Pfam:NAD_binding_8 7 72 4.3e-6 PFAM
Pfam:K_oxygenase 78 333 1.3e-12 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000143123
AA Change: K102*
SMART Domains Protein: ENSMUSP00000114226
Gene: ENSMUSG00000040170
AA Change: K102*

DomainStartEndE-ValueType
Pfam:FMO-like 2 161 1.2e-99 PFAM
Pfam:Pyr_redox_3 6 159 1.6e-8 PFAM
Pfam:NAD_binding_8 7 80 1.4e-7 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000156860
Predicted Effect noncoding transcript
Transcript: ENSMUST00000194061
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a flavin-containing monooxygenase family member. It is an NADPH-dependent enzyme that catalyzes the N-oxidation of some primary alkylamines through an N-hydroxylamine intermediate. However, some human populations contain an allele (FMO2*2A) with a premature stop codon, resulting in a protein that is C-terminally-truncated, has no catalytic activity, and is likely degraded rapidly. This gene is found in a cluster with other related family members on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]
Allele List at MGI
Other mutations in this stock
Total: 25 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actr3 C T 1: 125,395,076 A385T probably damaging Het
Cdh17 A T 4: 11,797,780 probably benign Het
Cntnap1 C T 11: 101,183,205 probably benign Het
Dhrs7 T A 12: 72,652,390 M296L probably damaging Het
Foxn3 T C 12: 99,196,607 E345G possibly damaging Het
Gabrg1 A G 5: 70,815,955 probably null Het
Gp1ba A C 11: 70,639,918 probably benign Het
Grwd1 A G 7: 45,830,613 Y57H probably damaging Het
Hars2 G A 18: 36,785,936 C83Y probably damaging Het
Il5ra C T 6: 106,712,474 probably benign Het
Itpr3 T C 17: 27,083,629 V87A probably benign Het
Lrig2 A G 3: 104,463,948 V455A probably damaging Het
P2ry10 T A X: 107,102,583 S41R probably damaging Het
Plcb2 C T 2: 118,713,734 probably null Het
Plod2 G A 9: 92,598,614 R420H probably damaging Het
Prkcd T C 14: 30,596,003 N656S probably damaging Het
Serpinb6a A G 13: 33,931,512 F42S possibly damaging Het
Sis A G 3: 72,934,124 I786T probably damaging Het
Slc5a11 C T 7: 123,250,174 A194V probably null Het
Spo11 T C 2: 172,989,032 probably null Het
Trap1a A G X: 139,334,234 D94G unknown Het
Urb1 A G 16: 90,753,321 probably null Het
Usp1 T C 4: 98,934,581 probably null Het
Zfp300 T C X: 21,084,254 D34G probably damaging Het
Zfp507 T C 7: 35,794,712 E302G possibly damaging Het
Other mutations in Fmo2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01299:Fmo2 APN 1 162878030 missense probably benign
IGL02617:Fmo2 APN 1 162876921 missense probably damaging 1.00
IGL02994:Fmo2 APN 1 162880620 missense probably damaging 1.00
IGL03270:Fmo2 APN 1 162882026 missense probably damaging 1.00
F5493:Fmo2 UTSW 1 162880532 missense probably benign 0.41
R0058:Fmo2 UTSW 1 162886324 missense probably benign 0.38
R0058:Fmo2 UTSW 1 162886324 missense probably benign 0.38
R0501:Fmo2 UTSW 1 162876928 missense probably benign 0.00
R0658:Fmo2 UTSW 1 162876774 missense possibly damaging 0.57
R0800:Fmo2 UTSW 1 162876814 missense probably benign 0.00
R2223:Fmo2 UTSW 1 162898244 missense probably damaging 1.00
R4360:Fmo2 UTSW 1 162882014 missense probably damaging 0.99
R4523:Fmo2 UTSW 1 162887708 missense probably benign 0.44
R4755:Fmo2 UTSW 1 162888805 missense probably damaging 1.00
R6087:Fmo2 UTSW 1 162880433 missense probably benign 0.45
R6219:Fmo2 UTSW 1 162880516 missense probably damaging 0.97
R6668:Fmo2 UTSW 1 162877048 missense probably benign 0.15
R7042:Fmo2 UTSW 1 162880657 missense probably damaging 1.00
R7291:Fmo2 UTSW 1 162887702 missense probably benign 0.06
R7560:Fmo2 UTSW 1 162888749 missense probably damaging 1.00
R7580:Fmo2 UTSW 1 162877044 missense possibly damaging 0.46
R7657:Fmo2 UTSW 1 162888844 missense probably damaging 1.00
Z1176:Fmo2 UTSW 1 162887598 missense probably benign 0.01
Z1176:Fmo2 UTSW 1 162898274 missense probably damaging 1.00
Posted On2012-12-06