Incidental Mutation 'IGL00685:Foxn2'
ID 10806
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Foxn2
Ensembl Gene ENSMUSG00000034998
Gene Name forkhead box N2
Synonyms Fkh19, 6030465J18Rik, HTLF, 3230402J05Rik
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.254) question?
Stock # IGL00685
Quality Score
Status
Chromosome 17
Chromosomal Location 88748139-88797961 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 88770305 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 51 (S51P)
Ref Sequence ENSEMBL: ENSMUSP00000116123 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000112238] [ENSMUST00000141052] [ENSMUST00000155640]
AlphaFold E9Q7L6
Predicted Effect probably benign
Transcript: ENSMUST00000112238
AA Change: S51P

PolyPhen 2 Score 0.010 (Sensitivity: 0.96; Specificity: 0.77)
SMART Domains Protein: ENSMUSP00000107857
Gene: ENSMUSG00000034998
AA Change: S51P

DomainStartEndE-ValueType
FH 110 202 7.42e-50 SMART
low complexity region 314 323 N/A INTRINSIC
low complexity region 348 358 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000134107
Predicted Effect probably benign
Transcript: ENSMUST00000141052
AA Change: S51P

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000118378
Gene: ENSMUSG00000034998
AA Change: S51P

DomainStartEndE-ValueType
FH 110 203 2.15e-37 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000155640
AA Change: S51P

PolyPhen 2 Score 0.020 (Sensitivity: 0.95; Specificity: 0.80)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a forkhead domain binding protein and may function in the transcriptional regulation of the human T-cell leukemia virus long terminal repeat. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 5 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Fra10ac1 T A 19: 38,190,012 (GRCm39) K217N probably damaging Het
Klra9 T A 6: 130,159,369 (GRCm39) I215F probably damaging Het
Manea A G 4: 26,340,578 (GRCm39) L128P probably damaging Het
Odf2l A T 3: 144,833,634 (GRCm39) N138Y possibly damaging Het
Tas2r102 A G 6: 132,739,488 (GRCm39) N132S possibly damaging Het
Other mutations in Foxn2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00952:Foxn2 APN 17 88,783,308 (GRCm39) missense probably benign 0.03
IGL02232:Foxn2 APN 17 88,770,479 (GRCm39) missense probably benign 0.03
IGL02882:Foxn2 APN 17 88,770,375 (GRCm39) missense probably damaging 1.00
IGL02974:Foxn2 APN 17 88,770,543 (GRCm39) missense probably damaging 1.00
R1170:Foxn2 UTSW 17 88,781,094 (GRCm39) critical splice acceptor site probably benign
R1826:Foxn2 UTSW 17 88,794,233 (GRCm39) missense possibly damaging 0.87
R3825:Foxn2 UTSW 17 88,791,837 (GRCm39) missense probably damaging 0.98
R4761:Foxn2 UTSW 17 88,770,136 (GRCm39) splice site probably null
R5914:Foxn2 UTSW 17 88,770,138 (GRCm39) splice site probably null
R6735:Foxn2 UTSW 17 88,794,223 (GRCm39) missense probably benign
R7461:Foxn2 UTSW 17 88,794,311 (GRCm39) missense possibly damaging 0.93
R7613:Foxn2 UTSW 17 88,794,311 (GRCm39) missense possibly damaging 0.93
X0026:Foxn2 UTSW 17 88,794,161 (GRCm39) missense probably benign 0.00
Posted On 2012-12-06