Incidental Mutation 'IGL00763:Galp'
ID 10906
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Galp
Ensembl Gene ENSMUSG00000034660
Gene Name galanin-like peptide
Synonyms
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL00763
Quality Score
Status
Chromosome 7
Chromosomal Location 6200089-6219136 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 6211499 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Cysteine at position 40 (Y40C)
Ref Sequence ENSEMBL: ENSMUSP00000037408 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000037553]
AlphaFold Q810H5
Predicted Effect probably damaging
Transcript: ENSMUST00000037553
AA Change: Y40C

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000037408
Gene: ENSMUSG00000034660
AA Change: Y40C

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:Galanin 32 45 7.5e-10 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000130076
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the galanin family of neuropeptides. The encoded protein binds galanin receptors 1, 2 and 3 with the highest affinity for galanin receptor 3 and has been implicated in biological processes involving the central nervous system including hypothalamic regulation of metabolism and reproduction. A peptide encoded by a splice variant of this gene, termed alarin, has vasoactive properties, displays antimicrobial activity against E. coli, and may serve as a marker for neuroblastic tumors.[provided by RefSeq, Nov 2014]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit resistance to diet induced obesity. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 29 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Bmp3 A C 5: 99,020,238 (GRCm39) R220S possibly damaging Het
Bms1 A G 6: 118,395,363 (GRCm39) probably benign Het
Ccdc138 T A 10: 58,411,537 (GRCm39) F635Y probably damaging Het
Ccdc81 T C 7: 89,518,823 (GRCm39) probably benign Het
Cntnap5a T C 1: 116,045,407 (GRCm39) I341T possibly damaging Het
Cog5 C T 12: 31,715,531 (GRCm39) probably benign Het
Dcaf4 G A 12: 83,586,107 (GRCm39) R358H probably damaging Het
Ddx10 A C 9: 53,071,326 (GRCm39) probably benign Het
Fgf15 T A 7: 144,453,629 (GRCm39) F201I probably damaging Het
Ints6 A G 14: 62,938,314 (GRCm39) probably benign Het
Iqcb1 A T 16: 36,676,649 (GRCm39) probably benign Het
Kif19a G A 11: 114,657,994 (GRCm39) V18I probably benign Het
Lypd8l T G 11: 58,503,707 (GRCm39) probably benign Het
Morc1 A C 16: 48,432,689 (GRCm39) Q719P probably damaging Het
Pla2g4a T C 1: 149,727,076 (GRCm39) D568G probably damaging Het
Plscr4 A G 9: 92,366,998 (GRCm39) E204G probably null Het
Rasgrf1 A G 9: 89,853,073 (GRCm39) T403A probably benign Het
Sec16b A G 1: 157,356,827 (GRCm39) T12A probably benign Het
Slc12a7 A T 13: 73,942,201 (GRCm39) N359I possibly damaging Het
Slc14a2 G T 18: 78,235,453 (GRCm39) D241E probably damaging Het
Slc23a2 G T 2: 131,943,420 (GRCm39) A27E probably benign Het
Slc38a8 T C 8: 120,220,958 (GRCm39) I200M probably benign Het
Thrap3 C T 4: 126,059,371 (GRCm39) G892S probably benign Het
Tmc6 A G 11: 117,669,872 (GRCm39) L20P probably damaging Het
Tnfsfm13 T C 11: 69,575,536 (GRCm39) D256G probably benign Het
Tonsl C T 15: 76,518,068 (GRCm39) A605T probably damaging Het
Usp28 A G 9: 48,939,463 (GRCm39) T240A probably benign Het
Zap70 A T 1: 36,818,333 (GRCm39) D340V possibly damaging Het
Zfp512b A T 2: 181,231,944 (GRCm39) F100I probably damaging Het
Other mutations in Galp
AlleleSourceChrCoordTypePredicted EffectPPH Score
R3713:Galp UTSW 7 6,216,836 (GRCm39) missense probably damaging 0.98
R9069:Galp UTSW 7 6,214,347 (GRCm39) missense possibly damaging 0.92
Posted On 2012-12-06