Incidental Mutation 'IGL00478:Glyat'
ID10982
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Glyat
Ensembl Gene ENSMUSG00000063683
Gene Nameglycine-N-acyltransferase
SynonymsA330009E03Rik
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL00478
Quality Score
Status
Chromosome19
Chromosomal Location12633308-12653911 bp(+) (GRCm38)
Type of Mutationsplice site
DNA Base Change (assembly) T to C at 12648133 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000114002 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000044976] [ENSMUST00000119960]
Predicted Effect probably benign
Transcript: ENSMUST00000044976
SMART Domains Protein: ENSMUSP00000043308
Gene: ENSMUSG00000063683

DomainStartEndE-ValueType
Pfam:Gly_acyl_tr_N 1 206 1.9e-90 PFAM
Pfam:Gly_acyl_tr_C 207 295 2.8e-46 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000119960
SMART Domains Protein: ENSMUSP00000114002
Gene: ENSMUSG00000063683

DomainStartEndE-ValueType
Pfam:Gly_acyl_tr_N 1 172 1.2e-91 PFAM
Pfam:Gly_acyl_tr_C 173 261 3.6e-46 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000123173
Predicted Effect noncoding transcript
Transcript: ENSMUST00000157069
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The glycine-N-acyltransferase protein conjugates glycine with acyl-CoA substrates in the mitochondria. The protein is thought to be important in the detoxification of endogenous and xenobiotic acyl-CoA's. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 19 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aars A G 8: 111,047,972 T578A possibly damaging Het
Ablim1 C T 19: 57,068,186 A359T probably damaging Het
Akap9 G A 5: 4,046,639 V2505M probably damaging Het
Alpk2 A T 18: 65,307,226 C365* probably null Het
C920021L13Rik A T 3: 95,887,485 probably benign Het
Chd3 A T 11: 69,357,062 V905E probably damaging Het
Cntrl T C 2: 35,160,601 V1529A probably damaging Het
Coro2a T C 4: 46,540,455 D488G probably benign Het
Dpf1 G T 7: 29,316,556 probably benign Het
Fga T A 3: 83,028,644 D59E probably benign Het
Ggh T A 4: 20,057,965 H175Q probably benign Het
Gpr137c T C 14: 45,278,745 V312A probably damaging Het
Myt1 T C 2: 181,801,115 S466P probably damaging Het
Nlrp5 A T 7: 23,441,788 D1078V probably damaging Het
Rad17 T C 13: 100,633,274 D259G probably damaging Het
Rpp14 G A 14: 8,083,934 G30E possibly damaging Het
Uspl1 A T 5: 149,215,214 T1075S possibly damaging Het
Vash1 T A 12: 86,680,268 I94N possibly damaging Het
Zfp770 T C 2: 114,197,465 E41G probably damaging Het
Other mutations in Glyat
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00766:Glyat APN 19 12651262 missense probably benign 0.19
IGL01288:Glyat APN 19 12650355 missense possibly damaging 0.56
IGL02296:Glyat APN 19 12651261 missense probably damaging 0.99
PIT4458001:Glyat UTSW 19 12648009 missense probably benign 0.34
R0416:Glyat UTSW 19 12651453 missense possibly damaging 0.87
R1463:Glyat UTSW 19 12648103 missense probably damaging 1.00
R1750:Glyat UTSW 19 12646315 missense probably benign 0.01
R2416:Glyat UTSW 19 12651254 missense possibly damaging 0.50
R2504:Glyat UTSW 19 12651398 missense possibly damaging 0.82
R2960:Glyat UTSW 19 12639850 missense probably damaging 1.00
R3958:Glyat UTSW 19 12639833 missense probably benign 0.05
R4126:Glyat UTSW 19 12651479 missense probably benign 0.03
R4561:Glyat UTSW 19 12651280 missense possibly damaging 0.88
R4705:Glyat UTSW 19 12651297 missense possibly damaging 0.68
R5062:Glyat UTSW 19 12650263 missense probably damaging 1.00
R5490:Glyat UTSW 19 12650281 missense probably benign 0.35
R7028:Glyat UTSW 19 12650359 missense probably benign 0.00
R7044:Glyat UTSW 19 12650265 missense probably benign 0.05
R7599:Glyat UTSW 19 12639808 missense probably damaging 0.99
Z1088:Glyat UTSW 19 12648009 missense probably benign 0.00
Posted On2012-12-06