Incidental Mutation 'IGL00828:Zfp980'
ID10996
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp980
Ensembl Gene ENSMUSG00000058186
Gene Namezinc finger protein 980
SynonymsGm13242
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.322) question?
Stock #IGL00828
Quality Score
Status
Chromosome4
Chromosomal Location145670685-145704441 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 145701991 bp
ZygosityHeterozygous
Amino Acid Change Histidine to Leucine at position 430 (H430L)
Ref Sequence ENSEMBL: ENSMUSP00000137589 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000105738] [ENSMUST00000180014]
Predicted Effect probably benign
Transcript: ENSMUST00000105738
AA Change: H430L

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000101364
Gene: ENSMUSG00000058186
AA Change: H430L

DomainStartEndE-ValueType
KRAB 28 90 1.46e-16 SMART
low complexity region 235 246 N/A INTRINSIC
ZnF_C2H2 251 273 1.84e-4 SMART
ZnF_C2H2 279 301 3.49e-5 SMART
ZnF_C2H2 307 329 1.95e-3 SMART
ZnF_C2H2 335 357 5.67e-5 SMART
ZnF_C2H2 363 385 1.98e-4 SMART
ZnF_C2H2 391 413 1.98e-4 SMART
ZnF_C2H2 419 441 2.4e-3 SMART
ZnF_C2H2 447 469 1.22e-4 SMART
ZnF_C2H2 475 497 5.67e-5 SMART
ZnF_C2H2 503 525 1.98e-4 SMART
ZnF_C2H2 531 553 6.88e-4 SMART
ZnF_C2H2 559 581 1.58e-3 SMART
ZnF_C2H2 587 609 1.22e-4 SMART
ZnF_C2H2 615 635 1.26e1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000180014
AA Change: H430L

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000137589
Gene: ENSMUSG00000058186
AA Change: H430L

DomainStartEndE-ValueType
KRAB 28 90 1.46e-16 SMART
low complexity region 235 246 N/A INTRINSIC
ZnF_C2H2 251 273 1.84e-4 SMART
ZnF_C2H2 279 301 3.49e-5 SMART
ZnF_C2H2 307 329 1.95e-3 SMART
ZnF_C2H2 335 357 5.67e-5 SMART
ZnF_C2H2 363 385 1.98e-4 SMART
ZnF_C2H2 391 413 1.98e-4 SMART
ZnF_C2H2 419 441 2.4e-3 SMART
ZnF_C2H2 447 469 1.22e-4 SMART
ZnF_C2H2 475 497 5.67e-5 SMART
ZnF_C2H2 503 525 1.98e-4 SMART
ZnF_C2H2 531 553 6.88e-4 SMART
ZnF_C2H2 559 581 1.58e-3 SMART
ZnF_C2H2 587 609 1.22e-4 SMART
ZnF_C2H2 615 635 1.26e1 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000180968
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 10 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrb3 T A 1: 25,488,119 I372F possibly damaging Het
Dcaf6 G A 1: 165,338,347 probably benign Het
Dph7 A T 2: 24,971,643 Q356L probably benign Het
Gpr107 A T 2: 31,177,783 probably null Het
Kmt2a T C 9: 44,820,776 probably benign Het
Pign A T 1: 105,554,120 Y816N probably damaging Het
Slc17a5 G A 9: 78,578,551 A84V probably benign Het
Trim6 A G 7: 104,230,743 T230A probably benign Het
Usp40 G A 1: 87,978,306 probably benign Het
Zmpste24 G A 4: 121,074,520 R303C possibly damaging Het
Other mutations in Zfp980
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0164:Zfp980 UTSW 4 145701997 missense probably benign
R0164:Zfp980 UTSW 4 145701997 missense probably benign
R1186:Zfp980 UTSW 4 145702083 missense probably benign
R1761:Zfp980 UTSW 4 145702042 missense probably damaging 1.00
R3726:Zfp980 UTSW 4 145702083 missense probably benign
R4049:Zfp980 UTSW 4 145702600 missense probably damaging 1.00
R4467:Zfp980 UTSW 4 145702083 missense probably benign
R4610:Zfp980 UTSW 4 145702083 missense probably benign
R4622:Zfp980 UTSW 4 145702057 missense probably damaging 1.00
R4873:Zfp980 UTSW 4 145702083 missense probably benign
R5008:Zfp980 UTSW 4 145702083 missense probably benign
R5027:Zfp980 UTSW 4 145702083 missense probably benign
R5497:Zfp980 UTSW 4 145701447 missense probably damaging 1.00
R5995:Zfp980 UTSW 4 145701909 nonsense probably null
R6125:Zfp980 UTSW 4 145702638 makesense probably null
R7353:Zfp980 UTSW 4 145702144 missense probably benign 0.06
R7675:Zfp980 UTSW 4 145701594 nonsense probably null
Posted On2012-12-06