Incidental Mutation 'IGL00861:Oosp3'
| ID |
11034 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Oosp3
|
| Ensembl Gene |
ENSMUSG00000055933 |
| Gene Name |
oocyte secreted protein 3 |
| Synonyms |
Gm97, LOC225923 |
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.255)
|
| Stock # |
IGL00861
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
19 |
| Chromosomal Location |
11674419-11689222 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 11689004 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Glycine
at position 84
(D84G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000112874
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000069760]
[ENSMUST00000119053]
|
| AlphaFold |
G5E8D7 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000069760
AA Change: D182G
PolyPhen 2
Score 0.026 (Sensitivity: 0.95; Specificity: 0.81)
|
| SMART Domains |
Protein: ENSMUSP00000064913
Gene: ENSMUSG00000055933
AA Change: D182G
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
21 |
N/A |
INTRINSIC |
|
PDB:3EF7|B
|
25 |
118 |
1e-5 |
PDB |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000119053
AA Change: D84G
PolyPhen 2
Score 0.026 (Sensitivity: 0.95; Specificity: 0.81)
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 22 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adm2 |
G |
A |
15: 89,207,488 (GRCm39) |
|
probably benign |
Het |
| Ambra1 |
T |
A |
2: 91,601,271 (GRCm39) |
D189E |
possibly damaging |
Het |
| Atg16l1 |
G |
A |
1: 87,702,560 (GRCm39) |
G274S |
probably damaging |
Het |
| Cdh20 |
C |
A |
1: 109,988,718 (GRCm39) |
|
probably benign |
Het |
| Chat |
T |
C |
14: 32,170,980 (GRCm39) |
Y173C |
probably damaging |
Het |
| Crygd |
C |
T |
1: 65,101,250 (GRCm39) |
R115Q |
probably benign |
Het |
| Ctnnd1 |
T |
C |
2: 84,434,096 (GRCm39) |
D874G |
probably damaging |
Het |
| Dbt |
G |
A |
3: 116,339,763 (GRCm39) |
G384S |
probably benign |
Het |
| Depdc5 |
T |
C |
5: 33,125,158 (GRCm39) |
|
probably null |
Het |
| Eef1b2 |
G |
A |
1: 63,217,665 (GRCm39) |
G91R |
probably damaging |
Het |
| Fut10 |
G |
T |
8: 31,725,733 (GRCm39) |
V163F |
probably damaging |
Het |
| Glmn |
A |
T |
5: 107,718,005 (GRCm39) |
M304K |
possibly damaging |
Het |
| Klra6 |
A |
G |
6: 130,000,663 (GRCm39) |
V47A |
possibly damaging |
Het |
| Lgi2 |
T |
C |
5: 52,695,463 (GRCm39) |
K491E |
probably benign |
Het |
| Lrrc72 |
T |
A |
12: 36,271,507 (GRCm39) |
Q138L |
probably benign |
Het |
| Nherf4 |
A |
G |
9: 44,160,933 (GRCm39) |
L211P |
possibly damaging |
Het |
| Nxph2 |
T |
A |
2: 23,289,974 (GRCm39) |
F109I |
probably damaging |
Het |
| Poc1b |
C |
T |
10: 98,965,514 (GRCm39) |
R106C |
probably benign |
Het |
| Ptk2 |
A |
G |
15: 73,134,396 (GRCm39) |
S568P |
probably damaging |
Het |
| Slc4a5 |
A |
G |
6: 83,276,453 (GRCm39) |
I1093V |
probably benign |
Het |
| Snx2 |
G |
A |
18: 53,343,869 (GRCm39) |
|
probably null |
Het |
| Washc5 |
G |
T |
15: 59,209,125 (GRCm39) |
T1033K |
probably damaging |
Het |
|
| Other mutations in Oosp3 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01959:Oosp3
|
APN |
19 |
11,678,286 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02006:Oosp3
|
APN |
19 |
11,676,784 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02231:Oosp3
|
APN |
19 |
11,676,803 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02836:Oosp3
|
APN |
19 |
11,678,332 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1669:Oosp3
|
UTSW |
19 |
11,678,378 (GRCm39) |
splice site |
probably benign |
|
|
R2045:Oosp3
|
UTSW |
19 |
11,676,733 (GRCm39) |
missense |
probably benign |
0.03 |
|
R2852:Oosp3
|
UTSW |
19 |
11,676,896 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4820:Oosp3
|
UTSW |
19 |
11,688,997 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5030:Oosp3
|
UTSW |
19 |
11,678,308 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5524:Oosp3
|
UTSW |
19 |
11,682,794 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R5641:Oosp3
|
UTSW |
19 |
11,674,537 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5933:Oosp3
|
UTSW |
19 |
11,682,753 (GRCm39) |
missense |
probably benign |
0.07 |
|
R7018:Oosp3
|
UTSW |
19 |
11,676,783 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7585:Oosp3
|
UTSW |
19 |
11,678,322 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7958:Oosp3
|
UTSW |
19 |
11,682,820 (GRCm39) |
missense |
probably benign |
0.07 |
|
R9238:Oosp3
|
UTSW |
19 |
11,676,753 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9684:Oosp3
|
UTSW |
19 |
11,682,806 (GRCm39) |
missense |
probably benign |
0.31 |
|
| Posted On |
2012-12-06 |
Incidental Mutation