Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL00473:Gpr15'

11098

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Gpr15

Ensembl Gene

ENSMUSG00000047293

Gene Name

G protein-coupled receptor 15

Synonyms

4933439K08Rik

Accession Numbers

Is this an essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL00473

Quality Score

Status

Chromosome

Chromosomal Location

58717433-58719070 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 58718078 bp

Zygosity

Heterozygous

Amino Acid Change

Cysteine to Tyrosine at position 216 (C216Y)

Ref Sequence

ENSEMBL: ENSMUSP00000086731 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000089318]

Predicted Effect

probably damaging
Transcript: ENSMUST00000089318
AA Change: C216Y

PolyPhen 2 Score 0.992 (Sensitivity: 0.70; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000086731
Gene: ENSMUSG00000047293
AA Change: C216Y

Domain	Start	End	E-Value	Type
Pfam:7tm_1	50	302	1.3e-46	PFAM
Pfam:7TM_GPCR_Srv	66	317	7.1e-9	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000231342

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000232532

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a G protein-coupled receptor that acts as a chemokine receptor for human immunodeficiency virus type 1 and 2. The encoded protein localizes to the cell membrane. [provided by RefSeq, Nov 2012]
PHENOTYPE: Mice homozygous for a a knock-out allele exhibit impaired regulatory T cell homing in the large intestine mucosa. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 30 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
3110043O21Rik	C	T	4: 35,213,616	G178E	possibly damaging	Het
Arcn1	A	G	9: 44,757,147	V264A	probably benign	Het
Asap1	T	C	15: 64,173,215		probably benign	Het
Brpf1	A	C	6: 113,316,684	Q571H	probably damaging	Het
Creb3	G	T	4: 43,565,517	R232L	probably benign	Het
Cst10	G	T	2: 149,405,373	S3I	unknown	Het
Cyp4a14	A	G	4: 115,489,952		probably benign	Het
Daxx	C	T	17: 33,911,607	Q199*	probably null	Het
Eml5	A	G	12: 98,805,492		probably benign	Het
Gbp6	T	A	5: 105,274,279	K520*	probably null	Het
Gcfc2	T	A	6: 81,944,374	C454S	probably damaging	Het
Gm9894	T	A	13: 67,765,117		noncoding transcript	Het
Gzmn	T	C	14: 56,166,979	K134E	probably benign	Het
Kat2b	T	G	17: 53,663,623	I679S	possibly damaging	Het
Klhl10	A	G	11: 100,456,414	Y478C	probably damaging	Het
Mapt	A	G	11: 104,287,183	D54G	probably damaging	Het
Mocs1	A	G	17: 49,433,201	E52G	probably benign	Het
Plekhn1	T	G	4: 156,223,363	T369P	probably damaging	Het
Prdm6	T	A	18: 53,540,285	F172L	probably benign	Het
Prl7b1	A	T	13: 27,604,590	V94D	probably damaging	Het
Rasal2	T	C	1: 157,147,817	T1116A	probably benign	Het
Rreb1	A	T	13: 37,930,791	K709*	probably null	Het
Ruvbl1	A	T	6: 88,491,568	R357W	probably damaging	Het
Slc4a5	T	C	6: 83,296,597	L973P	probably damaging	Het
Srp72	A	G	5: 76,984,176	Y234C	probably damaging	Het
Synrg	G	A	11: 84,039,246	M1070I	probably damaging	Het
Zan	A	T	5: 137,464,250	I889K	possibly damaging	Het
Zbtb40	G	A	4: 136,987,340	T1046M	probably damaging	Het
Zfp978	A	G	4: 147,390,860	N288S	probably benign	Het
Zfpm2	A	T	15: 41,099,287	K247M	probably damaging	Het

Other mutations in Gpr15

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02616:Gpr15	APN	16	58718204	missense	probably damaging	1.00
IGL03381:Gpr15	APN	16	58717976	missense	probably damaging	1.00
PIT4418001:Gpr15	UTSW	16	58717950	missense	probably benign	0.13
R1484:Gpr15	UTSW	16	58718574	missense	probably damaging	1.00
R1775:Gpr15	UTSW	16	58718558	missense	probably benign	0.05
R1959:Gpr15	UTSW	16	58718007	missense	probably benign	0.03
R1961:Gpr15	UTSW	16	58718007	missense	probably benign	0.03
R2127:Gpr15	UTSW	16	58718255	missense	possibly damaging	0.67
R3825:Gpr15	UTSW	16	58718360	missense	probably damaging	1.00
R4957:Gpr15	UTSW	16	58718174	missense	probably damaging	0.99
R5098:Gpr15	UTSW	16	58718527	missense	probably damaging	1.00
R5180:Gpr15	UTSW	16	58717885	missense	probably benign	0.07
R5668:Gpr15	UTSW	16	58717650	missense	probably damaging	1.00
R6104:Gpr15	UTSW	16	58717976	missense	probably damaging	1.00
R6281:Gpr15	UTSW	16	58718594	missense	probably damaging	1.00
R6921:Gpr15	UTSW	16	58717781	missense	probably benign	0.00
R6980:Gpr15	UTSW	16	58718742	start gained	probably benign
R6981:Gpr15	UTSW	16	58718185	missense	probably benign	0.44
R7252:Gpr15	UTSW	16	58718397	missense	probably damaging	1.00
R7643:Gpr15	UTSW	16	58717816	nonsense	probably null
R7680:Gpr15	UTSW	16	58717965	missense	probably damaging	1.00

Posted On

2012-12-06