Incidental Mutation 'IGL00731:Gpr155'
ID 11102
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gpr155
Ensembl Gene ENSMUSG00000041762
Gene Name G protein-coupled receptor 155
Synonyms DEPDC3, 1110017O10Rik, PGR22, F730029F15Rik
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL00731
Quality Score
Status
Chromosome 2
Chromosomal Location 73171850-73216842 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 73192957 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Proline at position 498 (L498P)
Ref Sequence ENSEMBL: ENSMUSP00000107675 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000076463] [ENSMUST00000112043] [ENSMUST00000112044]
AlphaFold A2AWR3
Predicted Effect noncoding transcript
Transcript: ENSMUST00000048504
SMART Domains Protein: ENSMUSP00000037772
Gene: ENSMUSG00000041762

DomainStartEndE-ValueType
Pfam:Mem_trans 40 205 1.9e-16 PFAM
Pfam:Mem_trans 187 360 4.9e-12 PFAM
transmembrane domain 380 402 N/A INTRINSIC
transmembrane domain 415 432 N/A INTRINSIC
transmembrane domain 442 464 N/A INTRINSIC
transmembrane domain 477 499 N/A INTRINSIC
transmembrane domain 519 538 N/A INTRINSIC
transmembrane domain 657 679 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000076463
AA Change: L526P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000075788
Gene: ENSMUSG00000041762
AA Change: L526P

DomainStartEndE-ValueType
Pfam:Mem_trans 40 205 3.3e-15 PFAM
transmembrane domain 209 231 N/A INTRINSIC
transmembrane domain 241 260 N/A INTRINSIC
transmembrane domain 272 291 N/A INTRINSIC
transmembrane domain 311 330 N/A INTRINSIC
transmembrane domain 343 365 N/A INTRINSIC
transmembrane domain 380 402 N/A INTRINSIC
transmembrane domain 415 432 N/A INTRINSIC
transmembrane domain 442 464 N/A INTRINSIC
transmembrane domain 477 499 N/A INTRINSIC
transmembrane domain 519 538 N/A INTRINSIC
transmembrane domain 657 679 N/A INTRINSIC
transmembrane domain 689 711 N/A INTRINSIC
DEP 759 833 8.28e-12 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000112043
AA Change: L526P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000107674
Gene: ENSMUSG00000041762
AA Change: L526P

DomainStartEndE-ValueType
Pfam:Mem_trans 40 205 3.3e-15 PFAM
transmembrane domain 209 231 N/A INTRINSIC
transmembrane domain 241 260 N/A INTRINSIC
transmembrane domain 272 291 N/A INTRINSIC
transmembrane domain 311 330 N/A INTRINSIC
transmembrane domain 343 365 N/A INTRINSIC
transmembrane domain 380 402 N/A INTRINSIC
transmembrane domain 415 432 N/A INTRINSIC
transmembrane domain 442 464 N/A INTRINSIC
transmembrane domain 477 499 N/A INTRINSIC
transmembrane domain 519 538 N/A INTRINSIC
transmembrane domain 657 679 N/A INTRINSIC
transmembrane domain 689 711 N/A INTRINSIC
DEP 759 833 8.28e-12 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000112044
AA Change: L498P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000107675
Gene: ENSMUSG00000041762
AA Change: L498P

DomainStartEndE-ValueType
Pfam:Mem_trans 40 205 3.3e-15 PFAM
Pfam:Mem_trans 187 360 8.3e-11 PFAM
transmembrane domain 382 404 N/A INTRINSIC
transmembrane domain 414 436 N/A INTRINSIC
transmembrane domain 449 471 N/A INTRINSIC
transmembrane domain 491 510 N/A INTRINSIC
transmembrane domain 629 651 N/A INTRINSIC
transmembrane domain 661 683 N/A INTRINSIC
DEP 731 805 8.28e-12 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000129184
Predicted Effect probably benign
Transcript: ENSMUST00000131430
SMART Domains Protein: ENSMUSP00000114294
Gene: ENSMUSG00000041762

DomainStartEndE-ValueType
transmembrane domain 98 120 N/A INTRINSIC
transmembrane domain 130 152 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000150705
Predicted Effect noncoding transcript
Transcript: ENSMUST00000184503
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 18 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aars1 A G 8: 111,771,501 (GRCm39) probably benign Het
Adcy10 T C 1: 165,400,183 (GRCm39) F1531L probably benign Het
Cgas G A 9: 78,342,770 (GRCm39) P344L probably damaging Het
Dab2 T C 15: 6,465,191 (GRCm39) S463P possibly damaging Het
Ehf C T 2: 103,097,185 (GRCm39) probably null Het
Fnbp4 G T 2: 90,598,987 (GRCm39) V704L probably benign Het
Gbp7 T C 3: 142,252,189 (GRCm39) S591P probably benign Het
Igll1 T C 16: 16,678,783 (GRCm39) T176A probably benign Het
Klk1b21 A G 7: 43,755,347 (GRCm39) E182G possibly damaging Het
Npat G A 9: 53,473,386 (GRCm39) E393K probably damaging Het
Npnt C T 3: 132,610,418 (GRCm39) probably null Het
Pde2a A G 7: 101,157,306 (GRCm39) Y693C probably benign Het
Ralgapa1 A G 12: 55,749,237 (GRCm39) S1269P possibly damaging Het
Rasal2 A C 1: 156,985,334 (GRCm39) D804E probably benign Het
Rdh10 A G 1: 16,178,099 (GRCm39) N124D probably benign Het
Slit3 G T 11: 35,512,981 (GRCm39) D536Y probably damaging Het
Snx24 C T 18: 53,517,681 (GRCm39) probably benign Het
Spink12 G A 18: 44,241,177 (GRCm39) probably benign Het
Other mutations in Gpr155
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01432:Gpr155 APN 2 73,182,229 (GRCm39) missense possibly damaging 0.51
IGL01528:Gpr155 APN 2 73,192,767 (GRCm39) critical splice donor site probably null
IGL01718:Gpr155 APN 2 73,212,576 (GRCm39) missense probably benign
IGL01733:Gpr155 APN 2 73,183,956 (GRCm39) splice site probably null
IGL03342:Gpr155 APN 2 73,180,022 (GRCm39) missense probably damaging 1.00
PIT1430001:Gpr155 UTSW 2 73,200,482 (GRCm39) missense probably benign 0.08
PIT4810001:Gpr155 UTSW 2 73,178,607 (GRCm39) missense probably benign 0.08
R0226:Gpr155 UTSW 2 73,197,936 (GRCm39) missense probably benign 0.02
R0399:Gpr155 UTSW 2 73,200,346 (GRCm39) missense possibly damaging 0.91
R0445:Gpr155 UTSW 2 73,200,488 (GRCm39) splice site probably benign
R1570:Gpr155 UTSW 2 73,200,382 (GRCm39) missense possibly damaging 0.87
R1598:Gpr155 UTSW 2 73,200,434 (GRCm39) missense probably damaging 0.98
R1647:Gpr155 UTSW 2 73,194,508 (GRCm39) splice site probably null
R1648:Gpr155 UTSW 2 73,194,508 (GRCm39) splice site probably null
R1756:Gpr155 UTSW 2 73,197,921 (GRCm39) missense probably benign 0.00
R1760:Gpr155 UTSW 2 73,212,279 (GRCm39) missense probably damaging 1.00
R2033:Gpr155 UTSW 2 73,178,526 (GRCm39) missense probably benign 0.18
R2044:Gpr155 UTSW 2 73,203,977 (GRCm39) missense probably damaging 1.00
R2145:Gpr155 UTSW 2 73,187,002 (GRCm39) missense probably benign 0.01
R2172:Gpr155 UTSW 2 73,212,471 (GRCm39) missense probably benign 0.00
R2274:Gpr155 UTSW 2 73,178,479 (GRCm39) critical splice donor site probably null
R3878:Gpr155 UTSW 2 73,198,736 (GRCm39) nonsense probably null
R3924:Gpr155 UTSW 2 73,200,420 (GRCm39) missense probably damaging 1.00
R4910:Gpr155 UTSW 2 73,197,882 (GRCm39) nonsense probably null
R4950:Gpr155 UTSW 2 73,212,529 (GRCm39) missense probably benign
R5337:Gpr155 UTSW 2 73,178,592 (GRCm39) missense probably benign 0.32
R5830:Gpr155 UTSW 2 73,200,433 (GRCm39) missense possibly damaging 0.93
R5887:Gpr155 UTSW 2 73,174,062 (GRCm39) nonsense probably null
R5929:Gpr155 UTSW 2 73,204,011 (GRCm39) nonsense probably null
R6293:Gpr155 UTSW 2 73,204,341 (GRCm39) missense possibly damaging 0.47
R6553:Gpr155 UTSW 2 73,179,989 (GRCm39) missense probably damaging 1.00
R6585:Gpr155 UTSW 2 73,179,989 (GRCm39) missense probably damaging 1.00
R7003:Gpr155 UTSW 2 73,173,961 (GRCm39) missense probably damaging 0.99
R7353:Gpr155 UTSW 2 73,197,835 (GRCm39) nonsense probably null
R7506:Gpr155 UTSW 2 73,198,683 (GRCm39) missense probably damaging 0.97
R7631:Gpr155 UTSW 2 73,213,291 (GRCm39) intron probably benign
R7753:Gpr155 UTSW 2 73,212,550 (GRCm39) missense probably benign 0.27
R7810:Gpr155 UTSW 2 73,212,296 (GRCm39) missense probably damaging 0.99
R7813:Gpr155 UTSW 2 73,212,329 (GRCm39) nonsense probably null
R7815:Gpr155 UTSW 2 73,192,904 (GRCm39) missense probably benign
R7873:Gpr155 UTSW 2 73,173,934 (GRCm39) missense possibly damaging 0.51
R8506:Gpr155 UTSW 2 73,173,806 (GRCm39) missense probably damaging 0.99
R8680:Gpr155 UTSW 2 73,174,039 (GRCm39) missense probably damaging 0.99
R8856:Gpr155 UTSW 2 73,203,993 (GRCm39) missense probably benign 0.27
R8872:Gpr155 UTSW 2 73,197,936 (GRCm39) missense probably benign 0.02
R9116:Gpr155 UTSW 2 73,204,109 (GRCm39) missense possibly damaging 0.78
R9683:Gpr155 UTSW 2 73,192,780 (GRCm39) missense probably benign
Posted On 2012-12-06