Incidental Mutation 'IGL00780:Gpr158'
ID 11106
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gpr158
Ensembl Gene ENSMUSG00000045967
Gene Name G protein-coupled receptor 158
Synonyms 5330427M13Rik
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL00780
Quality Score
Status
Chromosome 2
Chromosomal Location 21372378-21835355 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) A to T at 21831629 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Stop codon at position 910 (K910*)
Ref Sequence ENSEMBL: ENSMUSP00000049708 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000055946]
AlphaFold Q8C419
Predicted Effect probably null
Transcript: ENSMUST00000055946
AA Change: K910*
SMART Domains Protein: ENSMUSP00000049708
Gene: ENSMUSG00000045967
AA Change: K910*

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
low complexity region 110 125 N/A INTRINSIC
SCOP:d1edmb_ 313 359 5e-4 SMART
Blast:EGF 318 365 2e-27 BLAST
Pfam:7tm_3 426 669 1.2e-35 PFAM
low complexity region 840 863 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abi3bp A G 16: 56,423,168 (GRCm39) D440G probably null Het
Acvrl1 T A 15: 101,035,248 (GRCm39) F258Y probably damaging Het
Ano1 A G 7: 144,209,367 (GRCm39) S278P probably damaging Het
Aoc1l3 A G 6: 48,964,673 (GRCm39) D227G probably damaging Het
AW146154 T C 7: 41,129,883 (GRCm39) Y411C probably damaging Het
Blnk T A 19: 40,922,890 (GRCm39) K412M probably benign Het
Clpb C T 7: 101,427,815 (GRCm39) R387* probably null Het
Dach1 A T 14: 98,138,858 (GRCm39) N528K possibly damaging Het
Dag1 A T 9: 108,086,818 (GRCm39) W108R probably damaging Het
Elapor2 A G 5: 9,472,367 (GRCm39) T355A probably damaging Het
Fbn2 T C 18: 58,229,060 (GRCm39) T717A probably damaging Het
Fnbp1l T C 3: 122,342,898 (GRCm39) D394G possibly damaging Het
Gaa T A 11: 119,165,117 (GRCm39) probably null Het
Grb14 G A 2: 64,745,062 (GRCm39) P99S probably damaging Het
Gtf2h2 T C 13: 100,615,729 (GRCm39) D264G probably benign Het
Heatr3 A G 8: 88,897,568 (GRCm39) I667V probably benign Het
Hsp90ab1 T C 17: 45,880,490 (GRCm39) N407S probably damaging Het
Htr2a A T 14: 74,943,645 (GRCm39) L408F possibly damaging Het
Itgb5 G A 16: 33,705,345 (GRCm39) V212I probably damaging Het
Kmt2c G A 5: 25,516,049 (GRCm39) T2598I probably benign Het
Lcorl T C 5: 45,904,637 (GRCm39) N137S probably damaging Het
Lef1 T C 3: 130,986,779 (GRCm39) F212L possibly damaging Het
Map2k5 T C 9: 63,188,359 (GRCm39) probably benign Het
Med15 G A 16: 17,471,351 (GRCm39) T642I probably damaging Het
Nasp C A 4: 116,461,196 (GRCm39) E274* probably null Het
Nup210l A T 3: 90,098,156 (GRCm39) probably benign Het
Pgghg T C 7: 140,525,264 (GRCm39) probably null Het
Plpp1 A G 13: 112,988,040 (GRCm39) I54M probably damaging Het
Poldip3 C T 15: 83,022,680 (GRCm39) G35R probably damaging Het
Ppig A T 2: 69,563,268 (GRCm39) E81D possibly damaging Het
Ptpn21 G T 12: 98,646,630 (GRCm39) T999K probably damaging Het
Rad9b T C 5: 122,482,310 (GRCm39) I142V probably benign Het
Ralgps1 A T 2: 33,163,639 (GRCm39) H139Q probably damaging Het
Rdh16f2 T C 10: 127,710,961 (GRCm39) probably null Het
Sema3d G A 5: 12,574,293 (GRCm39) R265Q probably damaging Het
Tdp1 T C 12: 99,859,907 (GRCm39) V198A possibly damaging Het
Trim43c A T 9: 88,723,909 (GRCm39) D145V probably benign Het
Trpc4 C T 3: 54,209,596 (GRCm39) P654S probably damaging Het
Yy1 T G 12: 108,781,463 (GRCm39) I376S probably damaging Het
Zfp773 T A 7: 7,136,113 (GRCm39) Q161L probably benign Het
Other mutations in Gpr158
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00340:Gpr158 APN 2 21,373,494 (GRCm39) missense probably damaging 1.00
IGL00469:Gpr158 APN 2 21,751,606 (GRCm39) splice site probably benign
IGL00706:Gpr158 APN 2 21,751,584 (GRCm39) missense probably damaging 1.00
IGL00885:Gpr158 APN 2 21,653,832 (GRCm39) missense probably damaging 1.00
IGL01339:Gpr158 APN 2 21,373,842 (GRCm39) missense possibly damaging 0.73
IGL01368:Gpr158 APN 2 21,831,909 (GRCm39) missense probably damaging 1.00
IGL02141:Gpr158 APN 2 21,788,101 (GRCm39) missense probably damaging 0.99
IGL02455:Gpr158 APN 2 21,373,511 (GRCm39) missense probably benign 0.00
IGL02554:Gpr158 APN 2 21,831,407 (GRCm39) missense probably benign
IGL02681:Gpr158 APN 2 21,820,441 (GRCm39) missense probably damaging 1.00
IGL02752:Gpr158 APN 2 21,831,638 (GRCm39) missense possibly damaging 0.95
IGL02756:Gpr158 APN 2 21,831,890 (GRCm39) missense possibly damaging 0.47
IGL03181:Gpr158 APN 2 21,787,972 (GRCm39) missense probably benign 0.02
IGL03258:Gpr158 APN 2 21,830,085 (GRCm39) missense probably damaging 1.00
IGL03386:Gpr158 APN 2 21,831,057 (GRCm39) missense probably damaging 1.00
PIT4810001:Gpr158 UTSW 2 21,831,682 (GRCm39) missense probably benign 0.01
R0071:Gpr158 UTSW 2 21,815,479 (GRCm39) missense probably benign 0.08
R0081:Gpr158 UTSW 2 21,831,528 (GRCm39) missense probably damaging 1.00
R0528:Gpr158 UTSW 2 21,830,019 (GRCm39) missense probably damaging 1.00
R0560:Gpr158 UTSW 2 21,830,085 (GRCm39) missense probably damaging 1.00
R0603:Gpr158 UTSW 2 21,820,480 (GRCm39) missense possibly damaging 0.67
R1560:Gpr158 UTSW 2 21,831,125 (GRCm39) missense probably damaging 1.00
R1561:Gpr158 UTSW 2 21,820,505 (GRCm39) splice site probably null
R1609:Gpr158 UTSW 2 21,788,104 (GRCm39) missense possibly damaging 0.61
R1741:Gpr158 UTSW 2 21,832,359 (GRCm39) missense probably benign 0.00
R1827:Gpr158 UTSW 2 21,832,129 (GRCm39) missense probably benign
R1854:Gpr158 UTSW 2 21,373,935 (GRCm39) missense probably damaging 1.00
R1871:Gpr158 UTSW 2 21,820,426 (GRCm39) missense probably damaging 1.00
R2151:Gpr158 UTSW 2 21,832,325 (GRCm39) missense possibly damaging 0.82
R2273:Gpr158 UTSW 2 21,831,674 (GRCm39) missense probably benign
R2275:Gpr158 UTSW 2 21,831,674 (GRCm39) missense probably benign
R3004:Gpr158 UTSW 2 21,831,810 (GRCm39) missense probably damaging 0.99
R3151:Gpr158 UTSW 2 21,581,771 (GRCm39) missense possibly damaging 0.68
R3943:Gpr158 UTSW 2 21,373,370 (GRCm39) missense possibly damaging 0.65
R4238:Gpr158 UTSW 2 21,373,362 (GRCm39) missense probably damaging 1.00
R4379:Gpr158 UTSW 2 21,830,025 (GRCm39) missense probably damaging 1.00
R4381:Gpr158 UTSW 2 21,832,403 (GRCm39) missense probably damaging 1.00
R4464:Gpr158 UTSW 2 21,831,810 (GRCm39) missense probably damaging 0.99
R4467:Gpr158 UTSW 2 21,831,810 (GRCm39) missense probably damaging 0.99
R4496:Gpr158 UTSW 2 21,831,810 (GRCm39) missense probably damaging 0.99
R4506:Gpr158 UTSW 2 21,831,810 (GRCm39) missense probably damaging 0.99
R4530:Gpr158 UTSW 2 21,373,811 (GRCm39) missense probably benign 0.03
R4646:Gpr158 UTSW 2 21,831,864 (GRCm39) missense probably benign
R4798:Gpr158 UTSW 2 21,787,993 (GRCm39) missense probably damaging 1.00
R4882:Gpr158 UTSW 2 21,830,059 (GRCm39) missense probably damaging 0.98
R4943:Gpr158 UTSW 2 21,831,968 (GRCm39) missense probably damaging 1.00
R5334:Gpr158 UTSW 2 21,832,316 (GRCm39) missense probably benign 0.01
R5560:Gpr158 UTSW 2 21,831,101 (GRCm39) missense possibly damaging 0.67
R5600:Gpr158 UTSW 2 21,832,046 (GRCm39) missense probably benign
R5637:Gpr158 UTSW 2 21,788,083 (GRCm39) missense probably benign 0.00
R5701:Gpr158 UTSW 2 21,751,520 (GRCm39) missense probably damaging 1.00
R5744:Gpr158 UTSW 2 21,373,331 (GRCm39) missense probably damaging 1.00
R5911:Gpr158 UTSW 2 21,373,932 (GRCm39) missense possibly damaging 0.95
R5991:Gpr158 UTSW 2 21,373,319 (GRCm39) missense probably damaging 0.99
R6200:Gpr158 UTSW 2 21,404,227 (GRCm39) missense probably damaging 0.97
R6306:Gpr158 UTSW 2 21,820,422 (GRCm39) missense possibly damaging 0.84
R6324:Gpr158 UTSW 2 21,815,365 (GRCm39) missense probably damaging 1.00
R6384:Gpr158 UTSW 2 21,831,099 (GRCm39) missense probably damaging 1.00
R6698:Gpr158 UTSW 2 21,831,921 (GRCm39) missense probably damaging 1.00
R6997:Gpr158 UTSW 2 21,653,802 (GRCm39) missense possibly damaging 0.46
R7086:Gpr158 UTSW 2 21,831,386 (GRCm39) missense probably benign 0.01
R7175:Gpr158 UTSW 2 21,373,113 (GRCm39) missense probably benign 0.13
R7197:Gpr158 UTSW 2 21,815,412 (GRCm39) missense probably damaging 0.99
R7293:Gpr158 UTSW 2 21,581,750 (GRCm39) missense possibly damaging 0.47
R7427:Gpr158 UTSW 2 21,832,129 (GRCm39) missense probably benign
R7515:Gpr158 UTSW 2 21,373,092 (GRCm39) missense probably damaging 1.00
R7730:Gpr158 UTSW 2 21,831,158 (GRCm39) missense probably damaging 1.00
R8122:Gpr158 UTSW 2 21,831,674 (GRCm39) missense probably benign
R8311:Gpr158 UTSW 2 21,373,701 (GRCm39) missense probably benign 0.00
R8754:Gpr158 UTSW 2 21,581,693 (GRCm39) missense probably benign 0.00
R8782:Gpr158 UTSW 2 21,404,149 (GRCm39) missense probably damaging 1.00
R8792:Gpr158 UTSW 2 21,558,137 (GRCm39) missense probably damaging 1.00
R8842:Gpr158 UTSW 2 21,581,751 (GRCm39) missense possibly damaging 0.88
R9009:Gpr158 UTSW 2 21,581,760 (GRCm39) missense probably damaging 1.00
R9102:Gpr158 UTSW 2 21,830,078 (GRCm39) missense probably damaging 1.00
R9150:Gpr158 UTSW 2 21,831,251 (GRCm39) missense probably benign 0.17
R9254:Gpr158 UTSW 2 21,373,042 (GRCm39) start gained probably benign
R9317:Gpr158 UTSW 2 21,832,037 (GRCm39) missense probably benign
R9379:Gpr158 UTSW 2 21,373,042 (GRCm39) start gained probably benign
R9428:Gpr158 UTSW 2 21,787,972 (GRCm39) missense probably benign
R9497:Gpr158 UTSW 2 21,831,825 (GRCm39) missense probably benign 0.00
R9667:Gpr158 UTSW 2 21,830,054 (GRCm39) missense probably damaging 0.99
R9681:Gpr158 UTSW 2 21,831,315 (GRCm39) missense probably damaging 0.99
X0062:Gpr158 UTSW 2 21,831,180 (GRCm39) missense probably damaging 1.00
Z1176:Gpr158 UTSW 2 21,815,501 (GRCm39) critical splice donor site probably null
Z1177:Gpr158 UTSW 2 21,832,083 (GRCm39) missense possibly damaging 0.46
Posted On 2012-12-06