Incidental Mutation 'IGL00508:Gpr45'
ID 11114
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gpr45
Ensembl Gene ENSMUSG00000041907
Gene Name G protein-coupled receptor 45
Synonyms 9230112G11Rik, PSP24alpha
Accession Numbers
Essential gene? Probably non essential (E-score: 0.167) question?
Stock # IGL00508
Quality Score
Status
Chromosome 1
Chromosomal Location 42992032-43074611 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 43071452 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Proline to Serine at position 32 (P32S)
Ref Sequence ENSEMBL: ENSMUSP00000135986 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000114761] [ENSMUST00000179766]
AlphaFold Q9EQQ4
Predicted Effect possibly damaging
Transcript: ENSMUST00000114761
AA Change: P32S

PolyPhen 2 Score 0.771 (Sensitivity: 0.85; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000110409
Gene: ENSMUSG00000041907
AA Change: P32S

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srx 42 188 5.5e-9 PFAM
Pfam:7TM_GPCR_Srsx 45 340 1.9e-7 PFAM
Pfam:7tm_1 51 325 2.4e-52 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000158463
Predicted Effect noncoding transcript
Transcript: ENSMUST00000179655
SMART Domains Protein: ENSMUSP00000136725
Gene: ENSMUSG00000096364

DomainStartEndE-ValueType
low complexity region 90 102 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000179766
AA Change: P32S

PolyPhen 2 Score 0.771 (Sensitivity: 0.85; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000135986
Gene: ENSMUSG00000041907
AA Change: P32S

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srx 42 189 7.1e-9 PFAM
Pfam:7TM_GPCR_Srsx 45 340 1.9e-7 PFAM
Pfam:7tm_1 51 325 2.1e-51 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This intronless gene encodes a member of the G protein-coupled receptor (GPCR) family. Members of this protein family contain seven putative transmembrane domains and may mediate signaling processes to the interior of the cell via activation of heterotrimeric G proteins. This protein may function in the central nervous system. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrv1 A C 13: 81,654,306 (GRCm39) D2188E probably damaging Het
Atrx A G X: 104,867,405 (GRCm39) S2026P probably damaging Het
Cacna1b A C 2: 24,547,301 (GRCm39) probably null Het
Cfap46 C T 7: 139,240,605 (GRCm39) S56N probably damaging Het
Cfap57 C T 4: 118,438,367 (GRCm39) probably null Het
Ckap5 T G 2: 91,436,601 (GRCm39) V1567G probably damaging Het
Cyp2c38 A T 19: 39,449,169 (GRCm39) Y61* probably null Het
D130052B06Rik A G 11: 33,549,402 (GRCm39) E7G unknown Het
Dhx38 A G 8: 110,283,566 (GRCm39) L527P possibly damaging Het
Dnaaf5 A G 5: 139,163,701 (GRCm39) N653D probably benign Het
Dnah8 T G 17: 31,074,904 (GRCm39) M4541R probably damaging Het
Dpyd A T 3: 118,858,636 (GRCm39) T617S probably benign Het
Fpr2 A T 17: 18,113,034 (GRCm39) N10I probably damaging Het
Frmd4a A T 2: 4,599,545 (GRCm39) K524* probably null Het
H2-Eb2 A T 17: 34,553,341 (GRCm39) I176F probably damaging Het
Hcrtr1 T A 4: 130,031,062 (GRCm39) N74I probably damaging Het
Ifi47 C T 11: 48,986,241 (GRCm39) Q3* probably null Het
Krt8 T A 15: 101,906,460 (GRCm39) M350L probably benign Het
Lilra6 A G 7: 3,914,553 (GRCm39) S533P probably benign Het
Map1b A T 13: 99,565,741 (GRCm39) S2327T unknown Het
Mcoln3 T A 3: 145,839,683 (GRCm39) I345N probably damaging Het
Mettl3 C A 14: 52,532,436 (GRCm39) probably benign Het
Mgat4a G A 1: 37,488,204 (GRCm39) R472* probably null Het
Micall1 A G 15: 79,014,768 (GRCm39) K715E probably damaging Het
Pak1 G T 7: 97,503,775 (GRCm39) G37C probably benign Het
Pomt2 T G 12: 87,166,401 (GRCm39) H426P probably damaging Het
Pou2f3 G A 9: 43,051,258 (GRCm39) P155S probably benign Het
Psg25 A G 7: 18,263,656 (GRCm39) Y56H probably benign Het
Rab9 G T X: 165,240,860 (GRCm39) Y150* probably null Het
Rhox2g T A X: 36,824,463 (GRCm39) N152I probably damaging Het
Sema6d T C 2: 124,498,844 (GRCm39) probably benign Het
Simc1 C A 13: 54,672,989 (GRCm39) Q446K probably benign Het
Svs5 G T 2: 164,078,962 (GRCm39) T315K possibly damaging Het
Syt9 C T 7: 107,024,574 (GRCm39) R156* probably null Het
Tmem260 A T 14: 48,746,578 (GRCm39) Y618F probably damaging Het
Wdr44 A G X: 23,666,783 (GRCm39) I719V possibly damaging Het
Zfp518a T G 19: 40,901,914 (GRCm39) I614M probably damaging Het
Other mutations in Gpr45
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01528:Gpr45 APN 1 43,072,383 (GRCm39) missense probably benign 0.00
IGL01833:Gpr45 APN 1 43,071,402 (GRCm39) missense probably benign
IGL02034:Gpr45 APN 1 43,072,478 (GRCm39) makesense probably null
IGL02230:Gpr45 APN 1 43,071,816 (GRCm39) missense probably damaging 1.00
IGL02279:Gpr45 APN 1 43,071,998 (GRCm39) missense probably damaging 0.96
IGL02394:Gpr45 APN 1 43,069,272 (GRCm39) intron probably benign
IGL02795:Gpr45 APN 1 43,071,653 (GRCm39) missense possibly damaging 0.82
IGL02902:Gpr45 APN 1 43,072,371 (GRCm39) missense possibly damaging 0.67
IGL03017:Gpr45 APN 1 43,071,516 (GRCm39) missense possibly damaging 0.95
expansive UTSW 1 43,071,998 (GRCm39) missense probably damaging 0.96
extensive UTSW 1 43,072,218 (GRCm39) missense probably damaging 1.00
omnipresent UTSW 1 43,071,534 (GRCm39) missense probably damaging 1.00
R0368:Gpr45 UTSW 1 43,072,176 (GRCm39) missense probably damaging 1.00
R2964:Gpr45 UTSW 1 43,071,668 (GRCm39) missense possibly damaging 0.87
R2965:Gpr45 UTSW 1 43,071,668 (GRCm39) missense possibly damaging 0.87
R2966:Gpr45 UTSW 1 43,071,668 (GRCm39) missense possibly damaging 0.87
R4551:Gpr45 UTSW 1 43,071,950 (GRCm39) missense probably benign 0.00
R4681:Gpr45 UTSW 1 43,072,068 (GRCm39) missense probably benign 0.00
R4821:Gpr45 UTSW 1 43,069,613 (GRCm39) intron probably benign
R4966:Gpr45 UTSW 1 43,072,280 (GRCm39) missense probably benign 0.00
R5054:Gpr45 UTSW 1 43,071,809 (GRCm39) missense probably benign 0.38
R5319:Gpr45 UTSW 1 43,071,998 (GRCm39) missense probably damaging 0.96
R5667:Gpr45 UTSW 1 43,072,218 (GRCm39) missense probably damaging 1.00
R5671:Gpr45 UTSW 1 43,072,218 (GRCm39) missense probably damaging 1.00
R7250:Gpr45 UTSW 1 43,071,531 (GRCm39) missense probably damaging 1.00
R8117:Gpr45 UTSW 1 43,072,475 (GRCm39) missense probably damaging 1.00
R8393:Gpr45 UTSW 1 43,071,395 (GRCm39) missense probably benign 0.00
R8752:Gpr45 UTSW 1 43,071,842 (GRCm39) missense possibly damaging 0.94
R8927:Gpr45 UTSW 1 43,072,314 (GRCm39) missense probably damaging 0.98
R8928:Gpr45 UTSW 1 43,072,314 (GRCm39) missense probably damaging 0.98
R9316:Gpr45 UTSW 1 43,071,534 (GRCm39) missense probably damaging 1.00
Posted On 2012-12-06