Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL00801:Gucy2g'

11190

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Gucy2g

Ensembl Gene

ENSMUSG00000055523

Gene Name

guanylate cyclase 2g

Synonyms

GC-G, 2410077I05Rik

Accession Numbers

Is this an essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL00801

Quality Score

Status

Chromosome

Chromosomal Location

55198297-55241236 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 55233103 bp

Zygosity

Heterozygous

Amino Acid Change

Arginine to Glutamine at position 322 (R322Q)

Ref Sequence

ENSEMBL: ENSMUSP00000068253 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000069183]

Predicted Effect

probably benign
Transcript: ENSMUST00000069183
AA Change: R322Q

PolyPhen 2 Score 0.010 (Sensitivity: 0.96; Specificity: 0.77)

SMART Domains

Protein: ENSMUSP00000068253
Gene: ENSMUSG00000055523
AA Change: R322Q

Domain	Start	End	E-Value	Type
low complexity region	27	38	N/A	INTRINSIC
Pfam:ANF_receptor	65	416	5.2e-36	PFAM
low complexity region	471	487	N/A	INTRINSIC
Pfam:Pkinase	574	826	2e-26	PFAM
Pfam:Pkinase_Tyr	577	826	6e-35	PFAM
CYCc	865	1059	6.42e-96	SMART

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Mice homozygous for a null mutation are viable and fertile with no gross abnormalities and are protected against acute ischemia induced renal injury. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 33 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930447C04Rik	T	C	12: 72,881,386	T524A	possibly damaging	Het
Abcb7	T	C	X: 104,295,978	I562V	possibly damaging	Het
Anapc4	T	A	5: 52,857,211	V472D	probably damaging	Het
Arhgef37	A	G	18: 61,499,834	Y511H	probably damaging	Het
Atxn3	A	G	12: 101,926,508	S316P	possibly damaging	Het
B3galt1	A	T	2: 68,117,976	T12S	possibly damaging	Het
Cdc14a	G	T	3: 116,294,844	S394*	probably null	Het
Celsr3	T	C	9: 108,842,576	V2458A	probably benign	Het
Cyr61	T	A	3: 145,648,610	D182V	probably damaging	Het
Dapk1	C	T	13: 60,761,248	T1225I	probably benign	Het
Fyb	A	G	15: 6,644,824	K647R	possibly damaging	Het
Gabra5	C	A	7: 57,488,988	W104L	probably damaging	Het
Gjb6	A	T	14: 57,124,041	N254K	possibly damaging	Het
Golga4	T	A	9: 118,538,926	L371Q	probably damaging	Het
Hnf1b	C	T	11: 83,855,924	A122V	probably damaging	Het
Insrr	C	T	3: 87,813,808	L1089F	probably damaging	Het
Knop1	A	G	7: 118,852,644	V284A	probably benign	Het
Krt86	C	T	15: 101,473,860	H104Y	probably benign	Het
Map1b	C	T	13: 99,430,097	E2039K	unknown	Het
Myof	A	G	19: 37,986,073	I206T	probably damaging	Het
Nf1	A	T	11: 79,428,700		probably benign	Het
Nol8	A	G	13: 49,662,228	D586G	probably benign	Het
Nudt5	T	C	2: 5,866,357	F166S	probably damaging	Het
Ociad1	T	A	5: 73,304,566	Y87N	probably damaging	Het
Qtrt2	T	C	16: 43,881,189	K3E	probably damaging	Het
Rictor	G	A	15: 6,794,534	V1627I	probably damaging	Het
Skint2	A	T	4: 112,625,991	M198L	possibly damaging	Het
Slitrk5	A	G	14: 111,680,665	M574V	probably benign	Het
Thbs1	A	G	2: 118,122,973	D957G	probably damaging	Het
Tmem198b	A	C	10: 128,803,145	L43R	probably damaging	Het
Trpa1	A	G	1: 14,891,333	M627T	probably damaging	Het
Zdbf2	T	C	1: 63,303,038	F192S	possibly damaging	Het
Zfp961	T	G	8: 71,965,888	M54R	probably damaging	Het

Other mutations in Gucy2g

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01954:Gucy2g	APN	19	55198691	missense	probably benign	0.01
IGL01969:Gucy2g	APN	19	55227438	missense	probably benign	0.00
IGL02164:Gucy2g	APN	19	55238023	missense	probably benign
IGL02534:Gucy2g	APN	19	55241068	missense	probably damaging	1.00
IGL02667:Gucy2g	APN	19	55206177	missense	possibly damaging	0.64
IGL02755:Gucy2g	APN	19	55210354	missense	probably benign	0.10
IGL03187:Gucy2g	APN	19	55231052	missense	possibly damaging	0.91
IGL03354:Gucy2g	APN	19	55233080	missense	possibly damaging	0.95
PIT4366001:Gucy2g	UTSW	19	55237782	missense	probably null	0.51
R0040:Gucy2g	UTSW	19	55217302	missense	possibly damaging	0.73
R0126:Gucy2g	UTSW	19	55241166	missense	probably benign
R0318:Gucy2g	UTSW	19	55237798	missense	probably benign	0.00
R0576:Gucy2g	UTSW	19	55198770	missense	probably damaging	1.00
R0604:Gucy2g	UTSW	19	55203087	missense	probably benign	0.00
R0962:Gucy2g	UTSW	19	55210284	nonsense	probably null
R1348:Gucy2g	UTSW	19	55222906	missense	possibly damaging	0.68
R1458:Gucy2g	UTSW	19	55215036	splice site	probably benign
R1693:Gucy2g	UTSW	19	55222926	missense	probably damaging	1.00
R1795:Gucy2g	UTSW	19	55199541	missense	probably damaging	1.00
R1804:Gucy2g	UTSW	19	55210309	missense	probably benign	0.34
R1830:Gucy2g	UTSW	19	55222930	missense	possibly damaging	0.94
R1902:Gucy2g	UTSW	19	55210237	missense	probably benign	0.20
R1927:Gucy2g	UTSW	19	55237759	missense	probably benign	0.02
R1969:Gucy2g	UTSW	19	55222896	missense	possibly damaging	0.90
R1969:Gucy2g	UTSW	19	55233053	missense	probably benign	0.42
R2071:Gucy2g	UTSW	19	55222340	missense	possibly damaging	0.72
R2842:Gucy2g	UTSW	19	55240947	missense	probably damaging	1.00
R2971:Gucy2g	UTSW	19	55210276	missense	probably damaging	1.00
R4202:Gucy2g	UTSW	19	55229769	missense	possibly damaging	0.96
R4405:Gucy2g	UTSW	19	55237837	missense	probably benign	0.08
R4407:Gucy2g	UTSW	19	55237837	missense	probably benign	0.08
R4614:Gucy2g	UTSW	19	55202147	nonsense	probably null
R4671:Gucy2g	UTSW	19	55238068	missense	probably damaging	1.00
R4684:Gucy2g	UTSW	19	55206256	missense	probably damaging	1.00
R4837:Gucy2g	UTSW	19	55226053	missense	probably benign
R4969:Gucy2g	UTSW	19	55226013	missense	probably benign
R5050:Gucy2g	UTSW	19	55240935	missense	probably benign	0.05
R5059:Gucy2g	UTSW	19	55226071	missense	probably benign	0.00
R5070:Gucy2g	UTSW	19	55229787	missense	probably damaging	0.98
R5288:Gucy2g	UTSW	19	55215116	missense	probably damaging	1.00
R5384:Gucy2g	UTSW	19	55215116	missense	probably damaging	1.00
R5386:Gucy2g	UTSW	19	55215116	missense	probably damaging	1.00
R5497:Gucy2g	UTSW	19	55198701	missense	probably benign	0.00
R5531:Gucy2g	UTSW	19	55241140	missense	probably benign	0.24
R5536:Gucy2g	UTSW	19	55237927	missense	probably benign	0.05
R5679:Gucy2g	UTSW	19	55231079	missense	possibly damaging	0.87
R5715:Gucy2g	UTSW	19	55233155	missense	possibly damaging	0.93
R5941:Gucy2g	UTSW	19	55215131	missense	probably damaging	1.00
R6250:Gucy2g	UTSW	19	55217424	missense	probably damaging	0.99
R6288:Gucy2g	UTSW	19	55227513	missense	probably benign	0.01
R6378:Gucy2g	UTSW	19	55240945	missense	probably benign	0.00
R6605:Gucy2g	UTSW	19	55241028	missense	probably damaging	1.00
R7020:Gucy2g	UTSW	19	55233050	missense	probably damaging	0.98
R7064:Gucy2g	UTSW	19	55210332	missense	probably benign	0.01
R7078:Gucy2g	UTSW	19	55241151	missense	probably damaging	1.00
R7402:Gucy2g	UTSW	19	55206293	missense	probably damaging	1.00
R7539:Gucy2g	UTSW	19	55203154	missense	probably damaging	0.99
R7561:Gucy2g	UTSW	19	55206340	missense	probably benign	0.38
R7583:Gucy2g	UTSW	19	55235615	missense	probably damaging	1.00
R7804:Gucy2g	UTSW	19	55228152	missense	probably benign	0.02
R7880:Gucy2g	UTSW	19	55206280	missense	probably damaging	1.00
R7963:Gucy2g	UTSW	19	55206280	missense	probably damaging	1.00
Z1177:Gucy2g	UTSW	19	55210377	missense	probably benign	0.00

Posted On

2012-12-06