Incidental Mutation 'IGL00777:H1f4'
ID 11274
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol H1f4
Ensembl Gene ENSMUSG00000051627
Gene Name H1.4 linker histone, cluster member
Synonyms H1f4, H1-4, H1e, H1var2, Hist1h1e, H1s-4
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL00777
Quality Score
Status
Chromosome 13
Chromosomal Location 23805760-23806541 bp(-) (GRCm39)
Type of Mutation unclassified
DNA Base Change (assembly) T to A at 23806005 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000089296 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000051091] [ENSMUST00000062045] [ENSMUST00000091704]
AlphaFold P43274
Predicted Effect probably benign
Transcript: ENSMUST00000051091
SMART Domains Protein: ENSMUSP00000061247
Gene: ENSMUSG00000047246

DomainStartEndE-ValueType
low complexity region 2 18 N/A INTRINSIC
H2B 28 124 1.43e-72 SMART
Predicted Effect unknown
Transcript: ENSMUST00000062045
AA Change: K159M
SMART Domains Protein: ENSMUSP00000057308
Gene: ENSMUSG00000051627
AA Change: K159M

DomainStartEndE-ValueType
low complexity region 5 15 N/A INTRINSIC
H15 34 99 7.5e-23 SMART
low complexity region 116 219 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000091704
SMART Domains Protein: ENSMUSP00000089296
Gene: ENSMUSG00000047246

DomainStartEndE-ValueType
low complexity region 2 18 N/A INTRINSIC
H2B 28 124 1.43e-72 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000120330
Predicted Effect noncoding transcript
Transcript: ENSMUST00000129312
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. [provided by RefSeq, Aug 2015]
PHENOTYPE: Homozygotes for targeted null mutations are normal, but Hist1h1e/Hist1h1c double knockout males are significantly smaller than normal. The Hist1h1e/Hist1h1d/Hist1h1e triple knockout is lethal by embryonic day 12.5, and heterozygotes are underrepresented. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 23 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgra3 A G 5: 50,183,100 (GRCm39) I82T probably damaging Het
Cd72 T C 4: 43,448,365 (GRCm39) Y305C possibly damaging Het
Cldn34c1 T C X: 122,052,570 (GRCm39) L103P probably damaging Het
Dhtkd1 A T 2: 5,934,468 (GRCm39) L234H probably damaging Het
Hgd A G 16: 37,433,611 (GRCm39) T77A probably damaging Het
Itgad A T 7: 127,803,022 (GRCm39) T1059S probably damaging Het
Klhl20 T C 1: 160,937,325 (GRCm39) T17A probably benign Het
Lct T C 1: 128,215,293 (GRCm39) D1761G probably benign Het
Mmp23 T G 4: 155,735,464 (GRCm39) Y334S possibly damaging Het
Ncapg A G 5: 45,853,107 (GRCm39) S858G possibly damaging Het
Nsd1 G A 13: 55,386,548 (GRCm39) G101E probably damaging Het
Pdia3 T A 2: 121,260,037 (GRCm39) L192Q probably damaging Het
Phex A G X: 155,960,528 (GRCm39) L672P probably damaging Het
Reln A G 5: 22,223,848 (GRCm39) probably null Het
Rfk T A 19: 17,372,700 (GRCm39) V74E probably benign Het
Rubcn A G 16: 32,656,933 (GRCm39) C467R probably damaging Het
Rufy2 G A 10: 62,826,833 (GRCm39) C124Y probably damaging Het
Slc8a1 A G 17: 81,956,009 (GRCm39) I343T probably damaging Het
Smyd4 T A 11: 75,281,634 (GRCm39) M369K probably benign Het
Spata31e2 C A 1: 26,721,173 (GRCm39) D1336Y probably damaging Het
Tmem131l G T 3: 83,806,597 (GRCm39) P1408T probably damaging Het
Tmprss11f A G 5: 86,671,924 (GRCm39) Y423H probably damaging Het
Wdr70 A T 15: 8,049,088 (GRCm39) M303K probably benign Het
Other mutations in H1f4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03354:H1f4 APN 13 23,806,060 (GRCm39) unclassified probably benign
PIT4469001:H1f4 UTSW 13 23,806,362 (GRCm39) missense probably damaging 1.00
R2339:H1f4 UTSW 13 23,805,943 (GRCm39) unclassified probably benign
R3110:H1f4 UTSW 13 23,805,829 (GRCm39) unclassified probably benign
R3112:H1f4 UTSW 13 23,805,829 (GRCm39) unclassified probably benign
R3757:H1f4 UTSW 13 23,806,240 (GRCm39) nonsense probably null
R3758:H1f4 UTSW 13 23,806,240 (GRCm39) nonsense probably null
R5116:H1f4 UTSW 13 23,806,270 (GRCm39) missense probably damaging 1.00
R6034:H1f4 UTSW 13 23,806,296 (GRCm39) missense probably damaging 1.00
R6034:H1f4 UTSW 13 23,806,296 (GRCm39) missense probably damaging 1.00
R7008:H1f4 UTSW 13 23,806,192 (GRCm39) missense probably damaging 1.00
R7051:H1f4 UTSW 13 23,806,422 (GRCm39) missense probably benign 0.00
R7317:H1f4 UTSW 13 23,806,350 (GRCm39) missense probably damaging 1.00
R8220:H1f4 UTSW 13 23,805,922 (GRCm39) missense probably benign 0.23
Posted On 2012-12-06