Incidental Mutation 'IGL00757:Hrasls5'
ID11336
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Hrasls5
Ensembl Gene ENSMUSG00000024973
Gene NameHRAS-like suppressor family, member 5
Synonyms4921526K24Rik, 1700086E08Rik, 1700055A14Rik, iNAT
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL00757
Quality Score
Status
Chromosome19
Chromosomal Location7612541-7639642 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to T at 7614559 bp
ZygosityHeterozygous
Amino Acid Change Glutamic Acid to Aspartic acid at position 113 (E113D)
Ref Sequence ENSEMBL: ENSMUSP00000118096 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000025929] [ENSMUST00000148558]
Predicted Effect probably benign
Transcript: ENSMUST00000025929
AA Change: E113D

PolyPhen 2 Score 0.174 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000025929
Gene: ENSMUSG00000024973
AA Change: E113D

DomainStartEndE-ValueType
Pfam:LRAT 139 261 1.6e-39 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000131326
Predicted Effect possibly damaging
Transcript: ENSMUST00000148558
AA Change: E113D

PolyPhen 2 Score 0.481 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000118096
Gene: ENSMUSG00000024973
AA Change: E113D

DomainStartEndE-ValueType
Pfam:LRAT 144 261 1.9e-37 PFAM
low complexity region 294 305 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 25 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9530053A07Rik T G 7: 28,154,445 C1611W probably damaging Het
Acsbg1 A C 9: 54,622,719 I231R possibly damaging Het
Ahctf1 G A 1: 179,769,131 P94S probably damaging Het
Cldn34b3 T C X: 76,267,372 I182T possibly damaging Het
Cps1 T A 1: 67,152,380 probably benign Het
Cwf19l2 G T 9: 3,460,054 A781S probably damaging Het
Cyp4v3 T C 8: 45,320,615 I172M probably damaging Het
Gmnc T G 16: 26,963,939 D22A probably damaging Het
Gpr89 T A 3: 96,871,534 T408S probably benign Het
Grk2 A G 19: 4,289,311 probably null Het
Kctd3 A G 1: 188,972,196 S793P probably damaging Het
Lhx1 A G 11: 84,519,652 F373S probably damaging Het
Mgl2 A T 11: 70,135,150 I71F probably damaging Het
Nbeal1 T A 1: 60,195,143 I91N possibly damaging Het
Otog T A 7: 46,290,128 D2110E probably damaging Het
Pde9a A G 17: 31,443,172 E90G probably benign Het
Prdm10 T C 9: 31,318,546 V86A possibly damaging Het
R3hdm1 T G 1: 128,236,439 I1030R probably damaging Het
Ryr2 T A 13: 11,618,604 probably null Het
Serpina1f A G 12: 103,693,462 I187T probably damaging Het
Slc22a16 C T 10: 40,581,327 T188M probably damaging Het
Spg11 T C 2: 122,070,959 H1500R probably benign Het
Sptlc2 C T 12: 87,369,068 E62K probably damaging Het
Tgfbr1 T A 4: 47,405,581 S326T probably damaging Het
Tgif1 A G 17: 70,846,240 Y39H probably damaging Het
Other mutations in Hrasls5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00391:Hrasls5 APN 19 7619266 splice site probably benign
R0330:Hrasls5 UTSW 19 7637298 splice site probably null
R1144:Hrasls5 UTSW 19 7613330 missense probably benign 0.00
R1294:Hrasls5 UTSW 19 7614650 splice site probably benign
R1453:Hrasls5 UTSW 19 7639634 unclassified probably benign
R2069:Hrasls5 UTSW 19 7612638 missense possibly damaging 0.83
R2258:Hrasls5 UTSW 19 7612746 missense probably damaging 1.00
R2260:Hrasls5 UTSW 19 7612746 missense probably damaging 1.00
R5478:Hrasls5 UTSW 19 7614671 intron probably benign
R6151:Hrasls5 UTSW 19 7619291 missense probably damaging 1.00
R6274:Hrasls5 UTSW 19 7637466 missense probably damaging 1.00
R6746:Hrasls5 UTSW 19 7613330 missense probably benign 0.00
R6823:Hrasls5 UTSW 19 7639496 unclassified probably benign
R6912:Hrasls5 UTSW 19 7639465 unclassified probably benign
R7100:Hrasls5 UTSW 19 7639558 missense unknown
R7241:Hrasls5 UTSW 19 7614581 missense probably benign 0.01
Posted On2012-12-06