Incidental Mutation 'IGL00553:Ifi35'
ID 11404
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ifi35
Ensembl Gene ENSMUSG00000010358
Gene Name interferon-induced protein 35
Synonyms IFP35, 2010008K16Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.186) question?
Stock # IGL00553
Quality Score
Status
Chromosome 11
Chromosomal Location 101339238-101349527 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 101348152 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 86 (E86G)
Ref Sequence ENSEMBL: ENSMUSP00000010502 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000010502] [ENSMUST00000040430] [ENSMUST00000131024]
AlphaFold Q9D8C4
Predicted Effect probably damaging
Transcript: ENSMUST00000010502
AA Change: E86G

PolyPhen 2 Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000010502
Gene: ENSMUSG00000010358
AA Change: E86G

DomainStartEndE-ValueType
Pfam:IFP_35_N 8 80 9.1e-21 PFAM
Pfam:NID 81 170 1.5e-31 PFAM
Pfam:NID 179 266 1.6e-29 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000040430
SMART Domains Protein: ENSMUSP00000048350
Gene: ENSMUSG00000034993

DomainStartEndE-ValueType
low complexity region 3 31 N/A INTRINSIC
low complexity region 41 60 N/A INTRINSIC
Pfam:ADH_N 89 157 8.8e-11 PFAM
Pfam:ADH_zinc_N 213 355 2.1e-21 PFAM
Pfam:ADH_zinc_N_2 245 398 6.9e-22 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000125958
Predicted Effect probably benign
Transcript: ENSMUST00000131024
SMART Domains Protein: ENSMUSP00000117189
Gene: ENSMUSG00000010358

DomainStartEndE-ValueType
Pfam:IFP_35_N 8 45 2.7e-13 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000142107
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 19 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acr A G 15: 89,457,453 (GRCm39) I234V probably benign Het
Arid4a T C 12: 71,122,751 (GRCm39) L1044P probably benign Het
Bcl9 A T 3: 97,114,518 (GRCm39) D1035E probably damaging Het
Bptf G A 11: 106,946,105 (GRCm39) T2263I possibly damaging Het
Eprs1 G T 1: 185,139,345 (GRCm39) C910F probably benign Het
Glipr1 T C 10: 111,822,574 (GRCm39) N47S possibly damaging Het
Mx1 T A 16: 97,258,632 (GRCm39) I22F probably damaging Het
Nr2f1 A G 13: 78,346,361 (GRCm39) V111A probably damaging Het
Pdgfrb A T 18: 61,202,008 (GRCm39) E524V probably benign Het
Rspo3 A G 10: 29,330,148 (GRCm39) probably benign Het
Setdb2 C T 14: 59,653,241 (GRCm39) V354M probably damaging Het
Slc28a3 A G 13: 58,710,823 (GRCm39) probably null Het
Stau1 T C 2: 166,793,254 (GRCm39) K294E possibly damaging Het
Susd3 A T 13: 49,384,614 (GRCm39) *270R probably null Het
Ttc39b T C 4: 83,162,276 (GRCm39) probably benign Het
Usf1 T C 1: 171,244,843 (GRCm39) V169A probably damaging Het
Usp8 T C 2: 126,600,480 (GRCm39) L1077P probably damaging Het
Vsnl1 A G 12: 11,382,190 (GRCm39) F64L probably damaging Het
Zmiz1 T A 14: 25,572,494 (GRCm39) M1K probably null Het
Other mutations in Ifi35
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0362:Ifi35 UTSW 11 101,348,038 (GRCm39) missense probably benign 0.02
R1753:Ifi35 UTSW 11 101,347,461 (GRCm39) missense probably damaging 1.00
R1982:Ifi35 UTSW 11 101,349,112 (GRCm39) missense probably damaging 0.99
R3522:Ifi35 UTSW 11 101,348,511 (GRCm39) missense probably benign 0.25
R3704:Ifi35 UTSW 11 101,339,430 (GRCm39) start codon destroyed probably null 0.08
R4553:Ifi35 UTSW 11 101,348,717 (GRCm39) missense probably damaging 1.00
R5864:Ifi35 UTSW 11 101,349,069 (GRCm39) missense probably damaging 1.00
R7222:Ifi35 UTSW 11 101,348,341 (GRCm39) missense probably benign 0.00
R7992:Ifi35 UTSW 11 101,348,307 (GRCm39) nonsense probably null
R8255:Ifi35 UTSW 11 101,348,608 (GRCm39) missense probably benign 0.08
R9183:Ifi35 UTSW 11 101,348,091 (GRCm39) missense probably benign
Posted On 2012-12-06