Incidental Mutation 'IGL00553:Ifi35'
ID |
11404 |
Institutional Source |
Australian Phenomics Network
(link to record)
|
Gene Symbol |
Ifi35
|
Ensembl Gene |
ENSMUSG00000010358 |
Gene Name |
interferon-induced protein 35 |
Synonyms |
IFP35, 2010008K16Rik |
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.186)
|
Stock # |
IGL00553
|
Quality Score |
|
Status
|
|
Chromosome |
11 |
Chromosomal Location |
101339238-101349527 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to G
at 101348152 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Glutamic Acid to Glycine
at position 86
(E86G)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000010502
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000010502]
[ENSMUST00000040430]
[ENSMUST00000131024]
|
AlphaFold |
Q9D8C4 |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000010502
AA Change: E86G
PolyPhen 2
Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)
|
SMART Domains |
Protein: ENSMUSP00000010502 Gene: ENSMUSG00000010358 AA Change: E86G
Domain | Start | End | E-Value | Type |
Pfam:IFP_35_N
|
8 |
80 |
9.1e-21 |
PFAM |
Pfam:NID
|
81 |
170 |
1.5e-31 |
PFAM |
Pfam:NID
|
179 |
266 |
1.6e-29 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000040430
|
SMART Domains |
Protein: ENSMUSP00000048350 Gene: ENSMUSG00000034993
Domain | Start | End | E-Value | Type |
low complexity region
|
3 |
31 |
N/A |
INTRINSIC |
low complexity region
|
41 |
60 |
N/A |
INTRINSIC |
Pfam:ADH_N
|
89 |
157 |
8.8e-11 |
PFAM |
Pfam:ADH_zinc_N
|
213 |
355 |
2.1e-21 |
PFAM |
Pfam:ADH_zinc_N_2
|
245 |
398 |
6.9e-22 |
PFAM |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000125958
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000131024
|
SMART Domains |
Protein: ENSMUSP00000117189 Gene: ENSMUSG00000010358
Domain | Start | End | E-Value | Type |
Pfam:IFP_35_N
|
8 |
45 |
2.7e-13 |
PFAM |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000142107
|
Coding Region Coverage |
|
Validation Efficiency |
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 19 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Acr |
A |
G |
15: 89,457,453 (GRCm39) |
I234V |
probably benign |
Het |
Arid4a |
T |
C |
12: 71,122,751 (GRCm39) |
L1044P |
probably benign |
Het |
Bcl9 |
A |
T |
3: 97,114,518 (GRCm39) |
D1035E |
probably damaging |
Het |
Bptf |
G |
A |
11: 106,946,105 (GRCm39) |
T2263I |
possibly damaging |
Het |
Eprs1 |
G |
T |
1: 185,139,345 (GRCm39) |
C910F |
probably benign |
Het |
Glipr1 |
T |
C |
10: 111,822,574 (GRCm39) |
N47S |
possibly damaging |
Het |
Mx1 |
T |
A |
16: 97,258,632 (GRCm39) |
I22F |
probably damaging |
Het |
Nr2f1 |
A |
G |
13: 78,346,361 (GRCm39) |
V111A |
probably damaging |
Het |
Pdgfrb |
A |
T |
18: 61,202,008 (GRCm39) |
E524V |
probably benign |
Het |
Rspo3 |
A |
G |
10: 29,330,148 (GRCm39) |
|
probably benign |
Het |
Setdb2 |
C |
T |
14: 59,653,241 (GRCm39) |
V354M |
probably damaging |
Het |
Slc28a3 |
A |
G |
13: 58,710,823 (GRCm39) |
|
probably null |
Het |
Stau1 |
T |
C |
2: 166,793,254 (GRCm39) |
K294E |
possibly damaging |
Het |
Susd3 |
A |
T |
13: 49,384,614 (GRCm39) |
*270R |
probably null |
Het |
Ttc39b |
T |
C |
4: 83,162,276 (GRCm39) |
|
probably benign |
Het |
Usf1 |
T |
C |
1: 171,244,843 (GRCm39) |
V169A |
probably damaging |
Het |
Usp8 |
T |
C |
2: 126,600,480 (GRCm39) |
L1077P |
probably damaging |
Het |
Vsnl1 |
A |
G |
12: 11,382,190 (GRCm39) |
F64L |
probably damaging |
Het |
Zmiz1 |
T |
A |
14: 25,572,494 (GRCm39) |
M1K |
probably null |
Het |
|
Other mutations in Ifi35 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
R0362:Ifi35
|
UTSW |
11 |
101,348,038 (GRCm39) |
missense |
probably benign |
0.02 |
R1753:Ifi35
|
UTSW |
11 |
101,347,461 (GRCm39) |
missense |
probably damaging |
1.00 |
R1982:Ifi35
|
UTSW |
11 |
101,349,112 (GRCm39) |
missense |
probably damaging |
0.99 |
R3522:Ifi35
|
UTSW |
11 |
101,348,511 (GRCm39) |
missense |
probably benign |
0.25 |
R3704:Ifi35
|
UTSW |
11 |
101,339,430 (GRCm39) |
start codon destroyed |
probably null |
0.08 |
R4553:Ifi35
|
UTSW |
11 |
101,348,717 (GRCm39) |
missense |
probably damaging |
1.00 |
R5864:Ifi35
|
UTSW |
11 |
101,349,069 (GRCm39) |
missense |
probably damaging |
1.00 |
R7222:Ifi35
|
UTSW |
11 |
101,348,341 (GRCm39) |
missense |
probably benign |
0.00 |
R7992:Ifi35
|
UTSW |
11 |
101,348,307 (GRCm39) |
nonsense |
probably null |
|
R8255:Ifi35
|
UTSW |
11 |
101,348,608 (GRCm39) |
missense |
probably benign |
0.08 |
R9183:Ifi35
|
UTSW |
11 |
101,348,091 (GRCm39) |
missense |
probably benign |
|
|
Posted On |
2012-12-06 |