Incidental Mutation 'IGL00798:Iigp1'
ID |
11432 |
Institutional Source |
Australian Phenomics Network
(link to record)
|
Gene Symbol |
Iigp1
|
Ensembl Gene |
ENSMUSG00000054072 |
Gene Name |
interferon inducible GTPase 1 |
Synonyms |
2900074L10Rik, Irga6 |
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.059)
|
Stock # |
IGL00798
|
Quality Score |
|
Status
|
|
Chromosome |
18 |
Chromosomal Location |
60509099-60525706 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to C
at 60524073 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Methionine to Threonine
at position 397
(M397T)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000063390
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000032473]
[ENSMUST00000066912]
|
AlphaFold |
Q9QZ85 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000032473
AA Change: M397T
PolyPhen 2
Score 0.014 (Sensitivity: 0.96; Specificity: 0.79)
|
SMART Domains |
Protein: ENSMUSP00000032473 Gene: ENSMUSG00000054072 AA Change: M397T
Domain | Start | End | E-Value | Type |
Pfam:IIGP
|
35 |
409 |
5.5e-182 |
PFAM |
Pfam:MMR_HSR1
|
71 |
210 |
1.4e-7 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000066912
AA Change: M397T
PolyPhen 2
Score 0.014 (Sensitivity: 0.96; Specificity: 0.79)
|
SMART Domains |
Protein: ENSMUSP00000063390 Gene: ENSMUSG00000054072 AA Change: M397T
Domain | Start | End | E-Value | Type |
Pfam:IIGP
|
35 |
409 |
7.9e-182 |
PFAM |
Pfam:MMR_HSR1
|
71 |
212 |
8.2e-9 |
PFAM |
|
Coding Region Coverage |
|
Validation Efficiency |
|
MGI Phenotype |
PHENOTYPE: Targeted deletion of this gene results in partial loss of IFN-gamma-mediated Toxoplasma gondii growth restriction in primary mouse astrocytes. [provided by MGI curators]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 13 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
A2m |
T |
A |
6: 121,647,969 (GRCm39) |
F1154I |
probably damaging |
Het |
Atxn2 |
A |
G |
5: 121,933,298 (GRCm39) |
K565E |
possibly damaging |
Het |
Brca2 |
T |
G |
5: 150,462,928 (GRCm39) |
S897R |
probably benign |
Het |
Cfap206 |
C |
T |
4: 34,721,562 (GRCm39) |
S162N |
probably damaging |
Het |
Gabrg1 |
G |
A |
5: 70,939,626 (GRCm39) |
R164W |
probably damaging |
Het |
Jmy |
A |
G |
13: 93,577,910 (GRCm39) |
S753P |
probably benign |
Het |
Myo5b |
A |
G |
18: 74,787,147 (GRCm39) |
|
probably benign |
Het |
Nr3c1 |
C |
T |
18: 39,619,924 (GRCm39) |
G121D |
probably damaging |
Het |
Nup98 |
A |
G |
7: 101,796,411 (GRCm39) |
F875S |
probably damaging |
Het |
Plk2 |
T |
C |
13: 110,534,568 (GRCm39) |
S354P |
probably benign |
Het |
Prkci |
T |
C |
3: 31,088,648 (GRCm39) |
V179A |
probably benign |
Het |
Slc12a1 |
T |
C |
2: 125,030,114 (GRCm39) |
I562T |
probably damaging |
Het |
Zfp735 |
T |
A |
11: 73,602,386 (GRCm39) |
N443K |
possibly damaging |
Het |
|
Other mutations in Iigp1 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL03323:Iigp1
|
APN |
18 |
60,522,896 (GRCm39) |
missense |
probably benign |
0.04 |
R0025:Iigp1
|
UTSW |
18 |
60,523,859 (GRCm39) |
missense |
possibly damaging |
0.53 |
R0410:Iigp1
|
UTSW |
18 |
60,523,375 (GRCm39) |
missense |
probably benign |
0.15 |
R0564:Iigp1
|
UTSW |
18 |
60,523,523 (GRCm39) |
missense |
probably damaging |
0.98 |
R0609:Iigp1
|
UTSW |
18 |
60,522,896 (GRCm39) |
missense |
probably benign |
0.04 |
R1549:Iigp1
|
UTSW |
18 |
60,522,948 (GRCm39) |
missense |
probably benign |
|
R2226:Iigp1
|
UTSW |
18 |
60,522,960 (GRCm39) |
missense |
possibly damaging |
0.55 |
R2264:Iigp1
|
UTSW |
18 |
60,523,738 (GRCm39) |
missense |
probably benign |
0.20 |
R3110:Iigp1
|
UTSW |
18 |
60,523,983 (GRCm39) |
missense |
probably benign |
0.01 |
R3112:Iigp1
|
UTSW |
18 |
60,523,983 (GRCm39) |
missense |
probably benign |
0.01 |
R4575:Iigp1
|
UTSW |
18 |
60,523,218 (GRCm39) |
missense |
probably benign |
0.02 |
R4795:Iigp1
|
UTSW |
18 |
60,522,964 (GRCm39) |
missense |
probably benign |
0.13 |
R5439:Iigp1
|
UTSW |
18 |
60,523,329 (GRCm39) |
missense |
probably damaging |
1.00 |
R6565:Iigp1
|
UTSW |
18 |
60,523,839 (GRCm39) |
missense |
probably damaging |
1.00 |
R8775:Iigp1
|
UTSW |
18 |
60,523,596 (GRCm39) |
missense |
probably damaging |
1.00 |
R8775-TAIL:Iigp1
|
UTSW |
18 |
60,523,596 (GRCm39) |
missense |
probably damaging |
1.00 |
R9298:Iigp1
|
UTSW |
18 |
60,523,063 (GRCm39) |
missense |
probably benign |
0.00 |
R9520:Iigp1
|
UTSW |
18 |
60,523,451 (GRCm39) |
missense |
probably benign |
|
|
Posted On |
2012-12-06 |