Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00798:Iigp1'

11432

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Iigp1

Ensembl Gene

ENSMUSG00000054072

Gene Name

interferon inducible GTPase 1

Synonyms

2900074L10Rik, Irga6

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.059) question?

Stock #

IGL00798

Quality Score

Status

Chromosome

Chromosomal Location

60509099-60525706 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 60524073 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Threonine at position 397 (M397T)

Ref Sequence

ENSEMBL: ENSMUSP00000063390 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000032473] [ENSMUST00000066912]

AlphaFold

Q9QZ85

Predicted Effect

probably benign
Transcript: ENSMUST00000032473
AA Change: M397T

PolyPhen 2 Score 0.014 (Sensitivity: 0.96; Specificity: 0.79)

SMART Domains

Protein: ENSMUSP00000032473
Gene: ENSMUSG00000054072
AA Change: M397T

Domain	Start	End	E-Value	Type
Pfam:IIGP	35	409	5.5e-182	PFAM
Pfam:MMR_HSR1	71	210	1.4e-7	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000066912
AA Change: M397T

PolyPhen 2 Score 0.014 (Sensitivity: 0.96; Specificity: 0.79)

SMART Domains

Protein: ENSMUSP00000063390
Gene: ENSMUSG00000054072
AA Change: M397T

Domain	Start	End	E-Value	Type
Pfam:IIGP	35	409	7.9e-182	PFAM
Pfam:MMR_HSR1	71	212	8.2e-9	PFAM

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Targeted deletion of this gene results in partial loss of IFN-gamma-mediated Toxoplasma gondii growth restriction in primary mouse astrocytes. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 13 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A2m	T	A	6: 121,647,969 (GRCm39)	F1154I	probably damaging	Het
Atxn2	A	G	5: 121,933,298 (GRCm39)	K565E	possibly damaging	Het
Brca2	T	G	5: 150,462,928 (GRCm39)	S897R	probably benign	Het
Cfap206	C	T	4: 34,721,562 (GRCm39)	S162N	probably damaging	Het
Gabrg1	G	A	5: 70,939,626 (GRCm39)	R164W	probably damaging	Het
Jmy	A	G	13: 93,577,910 (GRCm39)	S753P	probably benign	Het
Myo5b	A	G	18: 74,787,147 (GRCm39)		probably benign	Het
Nr3c1	C	T	18: 39,619,924 (GRCm39)	G121D	probably damaging	Het
Nup98	A	G	7: 101,796,411 (GRCm39)	F875S	probably damaging	Het
Plk2	T	C	13: 110,534,568 (GRCm39)	S354P	probably benign	Het
Prkci	T	C	3: 31,088,648 (GRCm39)	V179A	probably benign	Het
Slc12a1	T	C	2: 125,030,114 (GRCm39)	I562T	probably damaging	Het
Zfp735	T	A	11: 73,602,386 (GRCm39)	N443K	possibly damaging	Het

Other mutations in Iigp1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL03323:Iigp1	APN	18	60,522,896 (GRCm39)	missense	probably benign	0.04
R0025:Iigp1	UTSW	18	60,523,859 (GRCm39)	missense	possibly damaging	0.53
R0410:Iigp1	UTSW	18	60,523,375 (GRCm39)	missense	probably benign	0.15
R0564:Iigp1	UTSW	18	60,523,523 (GRCm39)	missense	probably damaging	0.98
R0609:Iigp1	UTSW	18	60,522,896 (GRCm39)	missense	probably benign	0.04
R1549:Iigp1	UTSW	18	60,522,948 (GRCm39)	missense	probably benign
R2226:Iigp1	UTSW	18	60,522,960 (GRCm39)	missense	possibly damaging	0.55
R2264:Iigp1	UTSW	18	60,523,738 (GRCm39)	missense	probably benign	0.20
R3110:Iigp1	UTSW	18	60,523,983 (GRCm39)	missense	probably benign	0.01
R3112:Iigp1	UTSW	18	60,523,983 (GRCm39)	missense	probably benign	0.01
R4575:Iigp1	UTSW	18	60,523,218 (GRCm39)	missense	probably benign	0.02
R4795:Iigp1	UTSW	18	60,522,964 (GRCm39)	missense	probably benign	0.13
R5439:Iigp1	UTSW	18	60,523,329 (GRCm39)	missense	probably damaging	1.00
R6565:Iigp1	UTSW	18	60,523,839 (GRCm39)	missense	probably damaging	1.00
R8775:Iigp1	UTSW	18	60,523,596 (GRCm39)	missense	probably damaging	1.00
R8775-TAIL:Iigp1	UTSW	18	60,523,596 (GRCm39)	missense	probably damaging	1.00
R9298:Iigp1	UTSW	18	60,523,063 (GRCm39)	missense	probably benign	0.00
R9520:Iigp1	UTSW	18	60,523,451 (GRCm39)	missense	probably benign

Posted On

2012-12-06