Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL00087:Olfr401'

1157

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Olfr401

Ensembl Gene

ENSMUSG00000070380

Gene Name

olfactory receptor 401

Synonyms

MOR255-6, GA_x6K02T2P1NL-4278037-4278984

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.066) question?

Stock #

IGL00087

Quality Score

Status

Chromosome

Chromosomal Location

74113712-74122941 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 74121879 bp

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Phenylalanine at position 197 (I197F)

Ref Sequence

ENSEMBL: ENSMUSP00000149542 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000079827] [ENSMUST00000213754]

Predicted Effect

probably benign
Transcript: ENSMUST00000079827
AA Change: I197F

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000078756
Gene: ENSMUSG00000070380
AA Change: I197F

Domain	Start	End	E-Value	Type
Pfam:7tm_4	34	311	9.4e-51	PFAM
Pfam:7tm_1	44	293	2.2e-25	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000213754
AA Change: I197F

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

Meta Mutation Damage Score

0.0898

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 51 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930432M17Rik	C	A	3: 121,679,633		probably benign	Het
4930572O03Rik	C	A	5: 15,656,886		probably benign	Het
Actr2	C	A	11: 20,094,370	V79L	probably benign	Het
Ankrd36	A	C	11: 5,620,131	Y533S	probably benign	Het
Btnl1	A	T	17: 34,381,117	D198V	probably damaging	Het
Carmil2	T	A	8: 105,691,406	I684N	probably benign	Het
Ccdc129	T	A	6: 55,968,037	L581Q	possibly damaging	Het
Cdk17	T	A	10: 93,226,771	V257D	probably damaging	Het
Ctsj	T	G	13: 61,001,418	S271R	possibly damaging	Het
Cul9	T	A	17: 46,525,709	Q1130L	probably damaging	Het
Daam1	G	T	12: 71,942,219	S131I	unknown	Het
Dab1	G	A	4: 104,678,810	V139M	probably damaging	Het
Dab1	A	T	4: 104,678,753	I120F	possibly damaging	Het
Dnah2	A	G	11: 69,492,672	V1142A	possibly damaging	Het
Dsg1b	C	T	18: 20,396,476	T326I	probably damaging	Het
Eif3k	A	C	7: 28,974,676		probably benign	Het
Fam76b	T	C	9: 13,836,884	V3A	possibly damaging	Het
Fitm2	A	G	2: 163,469,792	V167A	probably benign	Het
Gfap	T	A	11: 102,888,718	I418F	possibly damaging	Het
Gm8857	C	T	5: 10,947,838		probably benign	Het
Grm5	T	C	7: 88,130,781	V1143A	probably benign	Het
Itpr2	A	G	6: 146,397,012	I317T	probably damaging	Het
Kcnn2	A	C	18: 45,592,236	R266S	probably damaging	Het
Kntc1	T	A	5: 123,790,159	S1240T	probably benign	Het
Lmnb2	T	C	10: 80,904,037	D490G	possibly damaging	Het
Muc4	G	A	16: 32,754,086	G1321R	probably benign	Het
Pax9	A	G	12: 56,700,075	N232S	probably benign	Het
Pdcd6ip	A	G	9: 113,697,518	S108P	possibly damaging	Het
Pitpnc1	T	C	11: 107,212,643	E210G	possibly damaging	Het
Prdm10	T	C	9: 31,360,812		probably benign	Het
Prl4a1	G	A	13: 28,021,460	G136E	probably damaging	Het
Pstpip2	A	G	18: 77,874,294	S255G	probably benign	Het
Rimbp3	T	G	16: 17,209,743	S344A	probably benign	Het
Rint1	A	G	5: 23,794,431	T73A	probably benign	Het
Rnf145	T	C	11: 44,555,212	V291A	possibly damaging	Het
Rrm1	T	A	7: 102,454,507	L221*	probably null	Het
Scn11a	A	G	9: 119,770,506	L1114P	probably benign	Het
Slc44a4	A	G	17: 34,930,240		probably benign	Het
Sorl1	A	C	9: 41,974,094	N2070K	probably damaging	Het
Spaca7	C	T	8: 12,580,941		probably benign	Het
Srsf6	G	T	2: 162,931,707	V13F	probably damaging	Het
Stab1	G	T	14: 31,161,357	T336N	probably benign	Het
Strbp	A	G	2: 37,586,504		probably benign	Het
Tbc1d4	A	G	14: 101,608,112	F117L	probably damaging	Het
Tcf20	A	G	15: 82,854,895	V785A	probably damaging	Het
Ticrr	A	G	7: 79,677,283	K580E	probably damaging	Het
Ubr4	A	T	4: 139,465,322	E4225D	possibly damaging	Het
Uck1	A	T	2: 32,259,669	V66D	probably damaging	Het
Vmn2r25	A	G	6: 123,853,171	F7S	probably benign	Het
Zan	C	T	5: 137,387,820		probably null	Het
Zfp819	T	A	7: 43,611,979		probably benign	Het

Other mutations in Olfr401

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01303:Olfr401	APN	11	74121334	missense	probably damaging	1.00
IGL01397:Olfr401	APN	11	74121764	missense	probably damaging	0.97
IGL02101:Olfr401	APN	11	74121745	nonsense	probably null
IGL02121:Olfr401	APN	11	74121287	splice site	probably benign
IGL02347:Olfr401	APN	11	74121571	missense	probably benign	0.03
IGL03113:Olfr401	APN	11	74121703	missense	probably benign	0.13
IGL03126:Olfr401	APN	11	74121784	missense	probably benign	0.01
IGL03302:Olfr401	APN	11	74121633	missense	possibly damaging	0.60
R0549:Olfr401	UTSW	11	74121475	missense	probably damaging	1.00
R1180:Olfr401	UTSW	11	74121580	missense	probably benign	0.28
R1350:Olfr401	UTSW	11	74122213	missense	possibly damaging	0.96
R1800:Olfr401	UTSW	11	74121408	missense	probably benign	0.00
R1808:Olfr401	UTSW	11	74121431	missense	probably damaging	0.96
R1962:Olfr401	UTSW	11	74121824	missense	probably benign	0.02
R1998:Olfr401	UTSW	11	74121580	missense	probably benign	0.28
R1999:Olfr401	UTSW	11	74121580	missense	probably benign	0.28
R2000:Olfr401	UTSW	11	74121580	missense	probably benign	0.28
R2859:Olfr401	UTSW	11	74121982	missense	probably damaging	1.00
R4914:Olfr401	UTSW	11	74121879	missense	probably benign	0.00
R4915:Olfr401	UTSW	11	74121879	missense	probably benign	0.00
R4916:Olfr401	UTSW	11	74121879	missense	probably benign	0.00
R4918:Olfr401	UTSW	11	74121879	missense	probably benign	0.00
R5292:Olfr401	UTSW	11	74122051	missense	probably damaging	0.99
R5522:Olfr401	UTSW	11	74121658	missense	probably damaging	1.00
R5761:Olfr401	UTSW	11	74121509	missense	probably damaging	0.97
R6318:Olfr401	UTSW	11	74121721	missense	possibly damaging	0.82
R6608:Olfr401	UTSW	11	74121628	missense	probably benign	0.00
R6737:Olfr401	UTSW	11	74121906	missense	probably benign
R6790:Olfr401	UTSW	11	74121601	missense	probably damaging	1.00
R7243:Olfr401	UTSW	11	74121733	missense	probably damaging	0.97
R7423:Olfr401	UTSW	11	74121985	missense	probably benign	0.01
R7517:Olfr401	UTSW	11	74121509	missense	probably damaging	0.97

Posted On

2011-07-12