Incidental Mutation 'IGL00087:Olfr401'
ID1157
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr401
Ensembl Gene ENSMUSG00000070380
Gene Nameolfactory receptor 401
SynonymsMOR255-6, GA_x6K02T2P1NL-4278037-4278984
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.066) question?
Stock #IGL00087
Quality Score
Status
Chromosome11
Chromosomal Location74113712-74122941 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 74121879 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 197 (I197F)
Ref Sequence ENSEMBL: ENSMUSP00000149542 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000079827] [ENSMUST00000213754]
Predicted Effect probably benign
Transcript: ENSMUST00000079827
AA Change: I197F

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000078756
Gene: ENSMUSG00000070380
AA Change: I197F

DomainStartEndE-ValueType
Pfam:7tm_4 34 311 9.4e-51 PFAM
Pfam:7tm_1 44 293 2.2e-25 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213754
AA Change: I197F

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930432M17Rik C A 3: 121,679,633 probably benign Het
4930572O03Rik C A 5: 15,656,886 probably benign Het
Actr2 C A 11: 20,094,370 V79L probably benign Het
Ankrd36 A C 11: 5,620,131 Y533S probably benign Het
Btnl1 A T 17: 34,381,117 D198V probably damaging Het
Carmil2 T A 8: 105,691,406 I684N probably benign Het
Ccdc129 T A 6: 55,968,037 L581Q possibly damaging Het
Cdk17 T A 10: 93,226,771 V257D probably damaging Het
Ctsj T G 13: 61,001,418 S271R possibly damaging Het
Cul9 T A 17: 46,525,709 Q1130L probably damaging Het
Daam1 G T 12: 71,942,219 S131I unknown Het
Dab1 G A 4: 104,678,810 V139M probably damaging Het
Dab1 A T 4: 104,678,753 I120F possibly damaging Het
Dnah2 A G 11: 69,492,672 V1142A possibly damaging Het
Dsg1b C T 18: 20,396,476 T326I probably damaging Het
Eif3k A C 7: 28,974,676 probably benign Het
Fam76b T C 9: 13,836,884 V3A possibly damaging Het
Fitm2 A G 2: 163,469,792 V167A probably benign Het
Gfap T A 11: 102,888,718 I418F possibly damaging Het
Gm8857 C T 5: 10,947,838 probably benign Het
Grm5 T C 7: 88,130,781 V1143A probably benign Het
Itpr2 A G 6: 146,397,012 I317T probably damaging Het
Kcnn2 A C 18: 45,592,236 R266S probably damaging Het
Kntc1 T A 5: 123,790,159 S1240T probably benign Het
Lmnb2 T C 10: 80,904,037 D490G possibly damaging Het
Muc4 G A 16: 32,754,086 G1321R probably benign Het
Pax9 A G 12: 56,700,075 N232S probably benign Het
Pdcd6ip A G 9: 113,697,518 S108P possibly damaging Het
Pitpnc1 T C 11: 107,212,643 E210G possibly damaging Het
Prdm10 T C 9: 31,360,812 probably benign Het
Prl4a1 G A 13: 28,021,460 G136E probably damaging Het
Pstpip2 A G 18: 77,874,294 S255G probably benign Het
Rimbp3 T G 16: 17,209,743 S344A probably benign Het
Rint1 A G 5: 23,794,431 T73A probably benign Het
Rnf145 T C 11: 44,555,212 V291A possibly damaging Het
Rrm1 T A 7: 102,454,507 L221* probably null Het
Scn11a A G 9: 119,770,506 L1114P probably benign Het
Slc44a4 A G 17: 34,930,240 probably benign Het
Sorl1 A C 9: 41,974,094 N2070K probably damaging Het
Spaca7 C T 8: 12,580,941 probably benign Het
Srsf6 G T 2: 162,931,707 V13F probably damaging Het
Stab1 G T 14: 31,161,357 T336N probably benign Het
Strbp A G 2: 37,586,504 probably benign Het
Tbc1d4 A G 14: 101,608,112 F117L probably damaging Het
Tcf20 A G 15: 82,854,895 V785A probably damaging Het
Ticrr A G 7: 79,677,283 K580E probably damaging Het
Ubr4 A T 4: 139,465,322 E4225D possibly damaging Het
Uck1 A T 2: 32,259,669 V66D probably damaging Het
Vmn2r25 A G 6: 123,853,171 F7S probably benign Het
Zan C T 5: 137,387,820 probably null Het
Zfp819 T A 7: 43,611,979 probably benign Het
Other mutations in Olfr401
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01303:Olfr401 APN 11 74121334 missense probably damaging 1.00
IGL01397:Olfr401 APN 11 74121764 missense probably damaging 0.97
IGL02101:Olfr401 APN 11 74121745 nonsense probably null
IGL02121:Olfr401 APN 11 74121287 splice site probably benign
IGL02347:Olfr401 APN 11 74121571 missense probably benign 0.03
IGL03113:Olfr401 APN 11 74121703 missense probably benign 0.13
IGL03126:Olfr401 APN 11 74121784 missense probably benign 0.01
IGL03302:Olfr401 APN 11 74121633 missense possibly damaging 0.60
R0549:Olfr401 UTSW 11 74121475 missense probably damaging 1.00
R1180:Olfr401 UTSW 11 74121580 missense probably benign 0.28
R1350:Olfr401 UTSW 11 74122213 missense possibly damaging 0.96
R1800:Olfr401 UTSW 11 74121408 missense probably benign 0.00
R1808:Olfr401 UTSW 11 74121431 missense probably damaging 0.96
R1962:Olfr401 UTSW 11 74121824 missense probably benign 0.02
R1998:Olfr401 UTSW 11 74121580 missense probably benign 0.28
R1999:Olfr401 UTSW 11 74121580 missense probably benign 0.28
R2000:Olfr401 UTSW 11 74121580 missense probably benign 0.28
R2859:Olfr401 UTSW 11 74121982 missense probably damaging 1.00
R4914:Olfr401 UTSW 11 74121879 missense probably benign 0.00
R4915:Olfr401 UTSW 11 74121879 missense probably benign 0.00
R4916:Olfr401 UTSW 11 74121879 missense probably benign 0.00
R4918:Olfr401 UTSW 11 74121879 missense probably benign 0.00
R5292:Olfr401 UTSW 11 74122051 missense probably damaging 0.99
R5522:Olfr401 UTSW 11 74121658 missense probably damaging 1.00
R5761:Olfr401 UTSW 11 74121509 missense probably damaging 0.97
R6318:Olfr401 UTSW 11 74121721 missense possibly damaging 0.82
R6608:Olfr401 UTSW 11 74121628 missense probably benign 0.00
R6737:Olfr401 UTSW 11 74121906 missense probably benign
R6790:Olfr401 UTSW 11 74121601 missense probably damaging 1.00
R7243:Olfr401 UTSW 11 74121733 missense probably damaging 0.97
R7423:Olfr401 UTSW 11 74121985 missense probably benign 0.01
R7517:Olfr401 UTSW 11 74121509 missense probably damaging 0.97
Posted On2011-07-12