Incidental Mutation 'IGL00087:Rnf145'
ID 1181
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Rnf145
Ensembl Gene ENSMUSG00000019189
Gene Name ring finger protein 145
Synonyms 3732413I11Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.206) question?
Stock # IGL00087
Quality Score
Status
Chromosome 11
Chromosomal Location 44409791-44456347 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 44446039 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 291 (V291A)
Ref Sequence ENSEMBL: ENSMUSP00000019333 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000019333] [ENSMUST00000101327]
AlphaFold Q5SWK7
Predicted Effect possibly damaging
Transcript: ENSMUST00000019333
AA Change: V291A

PolyPhen 2 Score 0.899 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000019333
Gene: ENSMUSG00000019189
AA Change: V291A

DomainStartEndE-ValueType
Pfam:TRC8_N 8 506 2.8e-156 PFAM
RING 537 574 2.12e-8 SMART
low complexity region 590 601 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000101327
SMART Domains Protein: ENSMUSP00000098881
Gene: ENSMUSG00000019189

DomainStartEndE-ValueType
Pfam:TRC8_N 7 266 1.2e-70 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000129676
Predicted Effect noncoding transcript
Transcript: ENSMUST00000150257
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930432M17Rik C A 3: 121,473,282 (GRCm39) probably benign Het
Actr2 C A 11: 20,044,370 (GRCm39) V79L probably benign Het
Ankrd36 A C 11: 5,570,131 (GRCm39) Y533S probably benign Het
Btnl1 A T 17: 34,600,091 (GRCm39) D198V probably damaging Het
Carmil2 T A 8: 106,418,038 (GRCm39) I684N probably benign Het
Cdk17 T A 10: 93,062,633 (GRCm39) V257D probably damaging Het
Ctsj T G 13: 61,149,232 (GRCm39) S271R possibly damaging Het
Cul9 T A 17: 46,836,635 (GRCm39) Q1130L probably damaging Het
Daam1 G T 12: 71,988,993 (GRCm39) S131I unknown Het
Dab1 G A 4: 104,536,007 (GRCm39) V139M probably damaging Het
Dab1 A T 4: 104,535,950 (GRCm39) I120F possibly damaging Het
Dnah2 A G 11: 69,383,498 (GRCm39) V1142A possibly damaging Het
Dsg1b C T 18: 20,529,533 (GRCm39) T326I probably damaging Het
Eif3k A C 7: 28,674,101 (GRCm39) probably benign Het
Fam76b T C 9: 13,748,180 (GRCm39) V3A possibly damaging Het
Fitm2 A G 2: 163,311,712 (GRCm39) V167A probably benign Het
Gfap T A 11: 102,779,544 (GRCm39) I418F possibly damaging Het
Grm5 T C 7: 87,779,989 (GRCm39) V1143A probably benign Het
Itpr2 A G 6: 146,298,510 (GRCm39) I317T probably damaging Het
Itprid1 T A 6: 55,945,022 (GRCm39) L581Q possibly damaging Het
Kcnn2 A C 18: 45,725,303 (GRCm39) R266S probably damaging Het
Kntc1 T A 5: 123,928,222 (GRCm39) S1240T probably benign Het
Lmnb2 T C 10: 80,739,871 (GRCm39) D490G possibly damaging Het
Muc4 G A 16: 32,754,086 (GRCm38) G1321R probably benign Het
Or3a1b A T 11: 74,012,705 (GRCm39) I197F probably benign Het
Pax9 A G 12: 56,746,860 (GRCm39) N232S probably benign Het
Pdcd6ip A G 9: 113,526,586 (GRCm39) S108P possibly damaging Het
Pitpnc1 T C 11: 107,103,469 (GRCm39) E210G possibly damaging Het
Prdm10 T C 9: 31,272,108 (GRCm39) probably benign Het
Prl4a1 G A 13: 28,205,443 (GRCm39) G136E probably damaging Het
Pstpip2 A G 18: 77,961,994 (GRCm39) S255G probably benign Het
Rimbp3 T G 16: 17,027,607 (GRCm39) S344A probably benign Het
Rint1 A G 5: 23,999,429 (GRCm39) T73A probably benign Het
Rrm1 T A 7: 102,103,714 (GRCm39) L221* probably null Het
Scn11a A G 9: 119,599,572 (GRCm39) L1114P probably benign Het
Slc44a4 A G 17: 35,149,216 (GRCm39) probably benign Het
Sorl1 A C 9: 41,885,390 (GRCm39) N2070K probably damaging Het
Spaca7 C T 8: 12,630,941 (GRCm39) probably benign Het
Speer1k C T 5: 10,997,805 (GRCm39) probably benign Het
Speer4c2 C A 5: 15,861,884 (GRCm39) probably benign Het
Srsf6 G T 2: 162,773,627 (GRCm39) V13F probably damaging Het
Stab1 G T 14: 30,883,314 (GRCm39) T336N probably benign Het
Strbp A G 2: 37,476,516 (GRCm39) probably benign Het
Tbc1d4 A G 14: 101,845,548 (GRCm39) F117L probably damaging Het
Tcf20 A G 15: 82,739,096 (GRCm39) V785A probably damaging Het
Ticrr A G 7: 79,327,031 (GRCm39) K580E probably damaging Het
Ubr4 A T 4: 139,192,633 (GRCm39) E4225D possibly damaging Het
Uck1 A T 2: 32,149,681 (GRCm39) V66D probably damaging Het
Vmn2r25 A G 6: 123,830,130 (GRCm39) F7S probably benign Het
Zan C T 5: 137,386,082 (GRCm39) probably null Het
Zfp819 T A 7: 43,261,403 (GRCm39) probably benign Het
Other mutations in Rnf145
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02972:Rnf145 APN 11 44,454,865 (GRCm39) missense probably benign 0.26
IGL03168:Rnf145 APN 11 44,445,985 (GRCm39) missense probably damaging 1.00
IGL03185:Rnf145 APN 11 44,422,157 (GRCm39) missense probably damaging 1.00
IGL02980:Rnf145 UTSW 11 44,452,484 (GRCm39) missense probably benign
R0112:Rnf145 UTSW 11 44,454,978 (GRCm39) missense probably benign
R0346:Rnf145 UTSW 11 44,445,991 (GRCm39) missense probably damaging 1.00
R0415:Rnf145 UTSW 11 44,415,965 (GRCm39) missense probably damaging 0.99
R0452:Rnf145 UTSW 11 44,452,587 (GRCm39) missense probably damaging 1.00
R0487:Rnf145 UTSW 11 44,446,056 (GRCm39) missense probably benign 0.21
R0598:Rnf145 UTSW 11 44,439,770 (GRCm39) missense probably damaging 1.00
R0631:Rnf145 UTSW 11 44,450,851 (GRCm39) missense probably damaging 0.99
R0837:Rnf145 UTSW 11 44,415,815 (GRCm39) missense probably benign 0.00
R1611:Rnf145 UTSW 11 44,442,625 (GRCm39) missense probably damaging 1.00
R1971:Rnf145 UTSW 11 44,439,642 (GRCm39) missense probably damaging 1.00
R1991:Rnf145 UTSW 11 44,452,293 (GRCm39) missense possibly damaging 0.90
R2157:Rnf145 UTSW 11 44,445,997 (GRCm39) missense probably damaging 1.00
R2340:Rnf145 UTSW 11 44,422,205 (GRCm39) missense probably benign 0.04
R3855:Rnf145 UTSW 11 44,422,120 (GRCm39) missense possibly damaging 0.46
R4483:Rnf145 UTSW 11 44,455,104 (GRCm39) missense probably benign 0.10
R4564:Rnf145 UTSW 11 44,439,635 (GRCm39) missense probably benign 0.25
R4922:Rnf145 UTSW 11 44,448,063 (GRCm39) unclassified probably benign
R5633:Rnf145 UTSW 11 44,450,915 (GRCm39) missense probably damaging 1.00
R5672:Rnf145 UTSW 11 44,422,120 (GRCm39) missense possibly damaging 0.46
R5673:Rnf145 UTSW 11 44,422,120 (GRCm39) missense possibly damaging 0.46
R5701:Rnf145 UTSW 11 44,422,120 (GRCm39) missense possibly damaging 0.46
R5915:Rnf145 UTSW 11 44,433,549 (GRCm39) critical splice donor site probably null
R6128:Rnf145 UTSW 11 44,446,018 (GRCm39) missense probably damaging 1.00
R6502:Rnf145 UTSW 11 44,415,932 (GRCm39) missense probably damaging 0.98
R6717:Rnf145 UTSW 11 44,452,317 (GRCm39) missense probably benign 0.00
R6963:Rnf145 UTSW 11 44,455,104 (GRCm39) missense probably benign 0.10
R7035:Rnf145 UTSW 11 44,452,583 (GRCm39) missense probably damaging 1.00
R7154:Rnf145 UTSW 11 44,415,822 (GRCm39) missense probably damaging 1.00
R7351:Rnf145 UTSW 11 44,439,623 (GRCm39) missense possibly damaging 0.91
R7639:Rnf145 UTSW 11 44,422,184 (GRCm39) missense probably damaging 1.00
R8074:Rnf145 UTSW 11 44,448,263 (GRCm39) missense probably damaging 0.98
R8536:Rnf145 UTSW 11 44,450,942 (GRCm39) missense probably damaging 1.00
R8861:Rnf145 UTSW 11 44,445,984 (GRCm39) missense probably damaging 1.00
R9123:Rnf145 UTSW 11 44,450,819 (GRCm39) missense probably damaging 1.00
R9125:Rnf145 UTSW 11 44,450,819 (GRCm39) missense probably damaging 1.00
R9172:Rnf145 UTSW 11 44,448,262 (GRCm39) missense possibly damaging 0.95
R9520:Rnf145 UTSW 11 44,452,336 (GRCm39) missense possibly damaging 0.91
R9711:Rnf145 UTSW 11 44,415,830 (GRCm39) nonsense probably null
R9801:Rnf145 UTSW 11 44,448,112 (GRCm39) missense probably damaging 0.99
Posted On 2011-07-12