Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL00087:Rnf145'

1181

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Rnf145

Ensembl Gene

ENSMUSG00000019189

Gene Name

ring finger protein 145

Synonyms

3732413I11Rik

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.182) question?

Stock #

IGL00087

Quality Score

Status

Chromosome

Chromosomal Location

44518964-44565520 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 44555212 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Valine to Alanine at position 291 (V291A)

Ref Sequence

ENSEMBL: ENSMUSP00000019333 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000019333] [ENSMUST00000101327]

AlphaFold

Q5SWK7

Predicted Effect

possibly damaging
Transcript: ENSMUST00000019333
AA Change: V291A

PolyPhen 2 Score 0.899 (Sensitivity: 0.82; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000019333
Gene: ENSMUSG00000019189
AA Change: V291A

Domain	Start	End	E-Value	Type
Pfam:TRC8_N	8	506	2.8e-156	PFAM
RING	537	574	2.12e-8	SMART
low complexity region	590	601	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000101327

SMART Domains

Protein: ENSMUSP00000098881
Gene: ENSMUSG00000019189

Domain	Start	End	E-Value	Type
Pfam:TRC8_N	7	266	1.2e-70	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000129676

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000150257

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 51 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930432M17Rik	C	A	3: 121,679,633		probably benign	Het
4930572O03Rik	C	A	5: 15,656,886		probably benign	Het
Actr2	C	A	11: 20,094,370	V79L	probably benign	Het
Ankrd36	A	C	11: 5,620,131	Y533S	probably benign	Het
Btnl1	A	T	17: 34,381,117	D198V	probably damaging	Het
Carmil2	T	A	8: 105,691,406	I684N	probably benign	Het
Ccdc129	T	A	6: 55,968,037	L581Q	possibly damaging	Het
Cdk17	T	A	10: 93,226,771	V257D	probably damaging	Het
Ctsj	T	G	13: 61,001,418	S271R	possibly damaging	Het
Cul9	T	A	17: 46,525,709	Q1130L	probably damaging	Het
Daam1	G	T	12: 71,942,219	S131I	unknown	Het
Dab1	G	A	4: 104,678,810	V139M	probably damaging	Het
Dab1	A	T	4: 104,678,753	I120F	possibly damaging	Het
Dnah2	A	G	11: 69,492,672	V1142A	possibly damaging	Het
Dsg1b	C	T	18: 20,396,476	T326I	probably damaging	Het
Eif3k	A	C	7: 28,974,676		probably benign	Het
Fam76b	T	C	9: 13,836,884	V3A	possibly damaging	Het
Fitm2	A	G	2: 163,469,792	V167A	probably benign	Het
Gfap	T	A	11: 102,888,718	I418F	possibly damaging	Het
Gm8857	C	T	5: 10,947,838		probably benign	Het
Grm5	T	C	7: 88,130,781	V1143A	probably benign	Het
Itpr2	A	G	6: 146,397,012	I317T	probably damaging	Het
Kcnn2	A	C	18: 45,592,236	R266S	probably damaging	Het
Kntc1	T	A	5: 123,790,159	S1240T	probably benign	Het
Lmnb2	T	C	10: 80,904,037	D490G	possibly damaging	Het
Muc4	G	A	16: 32,754,086	G1321R	probably benign	Het
Olfr401	A	T	11: 74,121,879	I197F	probably benign	Het
Pax9	A	G	12: 56,700,075	N232S	probably benign	Het
Pdcd6ip	A	G	9: 113,697,518	S108P	possibly damaging	Het
Pitpnc1	T	C	11: 107,212,643	E210G	possibly damaging	Het
Prdm10	T	C	9: 31,360,812		probably benign	Het
Prl4a1	G	A	13: 28,021,460	G136E	probably damaging	Het
Pstpip2	A	G	18: 77,874,294	S255G	probably benign	Het
Rimbp3	T	G	16: 17,209,743	S344A	probably benign	Het
Rint1	A	G	5: 23,794,431	T73A	probably benign	Het
Rrm1	T	A	7: 102,454,507	L221*	probably null	Het
Scn11a	A	G	9: 119,770,506	L1114P	probably benign	Het
Slc44a4	A	G	17: 34,930,240		probably benign	Het
Sorl1	A	C	9: 41,974,094	N2070K	probably damaging	Het
Spaca7	C	T	8: 12,580,941		probably benign	Het
Srsf6	G	T	2: 162,931,707	V13F	probably damaging	Het
Stab1	G	T	14: 31,161,357	T336N	probably benign	Het
Strbp	A	G	2: 37,586,504		probably benign	Het
Tbc1d4	A	G	14: 101,608,112	F117L	probably damaging	Het
Tcf20	A	G	15: 82,854,895	V785A	probably damaging	Het
Ticrr	A	G	7: 79,677,283	K580E	probably damaging	Het
Ubr4	A	T	4: 139,465,322	E4225D	possibly damaging	Het
Uck1	A	T	2: 32,259,669	V66D	probably damaging	Het
Vmn2r25	A	G	6: 123,853,171	F7S	probably benign	Het
Zan	C	T	5: 137,387,820		probably null	Het
Zfp819	T	A	7: 43,611,979		probably benign	Het

Other mutations in Rnf145

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02972:Rnf145	APN	11	44564038	missense	probably benign	0.26
IGL03168:Rnf145	APN	11	44555158	missense	probably damaging	1.00
IGL03185:Rnf145	APN	11	44531330	missense	probably damaging	1.00
IGL02980:Rnf145	UTSW	11	44561657	missense	probably benign
R0112:Rnf145	UTSW	11	44564151	missense	probably benign
R0346:Rnf145	UTSW	11	44555164	missense	probably damaging	1.00
R0415:Rnf145	UTSW	11	44525138	missense	probably damaging	0.99
R0452:Rnf145	UTSW	11	44561760	missense	probably damaging	1.00
R0487:Rnf145	UTSW	11	44555229	missense	probably benign	0.21
R0598:Rnf145	UTSW	11	44548943	missense	probably damaging	1.00
R0631:Rnf145	UTSW	11	44560024	missense	probably damaging	0.99
R0837:Rnf145	UTSW	11	44524988	missense	probably benign	0.00
R1611:Rnf145	UTSW	11	44551798	missense	probably damaging	1.00
R1971:Rnf145	UTSW	11	44548815	missense	probably damaging	1.00
R1991:Rnf145	UTSW	11	44561466	missense	possibly damaging	0.90
R2157:Rnf145	UTSW	11	44555170	missense	probably damaging	1.00
R2340:Rnf145	UTSW	11	44531378	missense	probably benign	0.04
R3855:Rnf145	UTSW	11	44531293	missense	possibly damaging	0.46
R4483:Rnf145	UTSW	11	44564277	missense	probably benign	0.10
R4564:Rnf145	UTSW	11	44548808	missense	probably benign	0.25
R4922:Rnf145	UTSW	11	44557236	unclassified	probably benign
R5633:Rnf145	UTSW	11	44560088	missense	probably damaging	1.00
R5672:Rnf145	UTSW	11	44531293	missense	possibly damaging	0.46
R5673:Rnf145	UTSW	11	44531293	missense	possibly damaging	0.46
R5701:Rnf145	UTSW	11	44531293	missense	possibly damaging	0.46
R5915:Rnf145	UTSW	11	44542722	critical splice donor site	probably null
R6128:Rnf145	UTSW	11	44555191	missense	probably damaging	1.00
R6502:Rnf145	UTSW	11	44525105	missense	probably damaging	0.98
R6717:Rnf145	UTSW	11	44561490	missense	probably benign	0.00
R6963:Rnf145	UTSW	11	44564277	missense	probably benign	0.10
R7035:Rnf145	UTSW	11	44561756	missense	probably damaging	1.00
R7154:Rnf145	UTSW	11	44524995	missense	probably damaging	1.00
R7351:Rnf145	UTSW	11	44548796	missense	possibly damaging	0.91
R7639:Rnf145	UTSW	11	44531357	missense	probably damaging	1.00
R8074:Rnf145	UTSW	11	44557436	missense	probably damaging	0.98
R8536:Rnf145	UTSW	11	44560115	missense	probably damaging	1.00
R8861:Rnf145	UTSW	11	44555157	missense	probably damaging	1.00
R9123:Rnf145	UTSW	11	44559992	missense	probably damaging	1.00
R9125:Rnf145	UTSW	11	44559992	missense	probably damaging	1.00
R9172:Rnf145	UTSW	11	44557435	missense	possibly damaging	0.95

Posted On

2011-07-12