Incidental Mutation 'IGL00495:Lrrc15'
ID11824
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Lrrc15
Ensembl Gene ENSMUSG00000052316
Gene Nameleucine rich repeat containing 15
Synonyms5430427N11Rik
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL00495
Quality Score
Status
Chromosome16
Chromosomal Location30269302-30283256 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 30274030 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 164 (I164F)
Ref Sequence ENSEMBL: ENSMUSP00000066777 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000064606]
Predicted Effect possibly damaging
Transcript: ENSMUST00000064606
AA Change: I164F

PolyPhen 2 Score 0.899 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000066777
Gene: ENSMUSG00000052316
AA Change: I164F

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
LRRNT 24 57 2.98e0 SMART
LRR 76 99 6.97e1 SMART
LRR_TYP 100 123 1.98e-4 SMART
LRR 124 147 4.08e0 SMART
LRR_TYP 148 171 2.4e-3 SMART
LRR_TYP 172 195 1.82e-3 SMART
LRR_TYP 196 219 1.18e-2 SMART
LRR_TYP 220 243 3.16e-3 SMART
LRR_TYP 245 267 3.39e-3 SMART
LRR_TYP 268 291 8.81e-2 SMART
LRR_TYP 292 315 9.5e-7 SMART
LRR_TYP 316 339 6.52e-5 SMART
LRR_TYP 340 363 7.78e-3 SMART
LRR_TYP 364 387 1.03e-2 SMART
LRR 388 411 8.48e0 SMART
LRRCT 423 474 1.11e-3 SMART
low complexity region 485 512 N/A INTRINSIC
transmembrane domain 537 559 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ankk1 T C 9: 49,415,843 T679A probably benign Het
Bhlhe40 T A 6: 108,661,178 M33K probably benign Het
Cacna2d1 T C 5: 16,370,609 S1059P probably benign Het
Cdkn1a C A 17: 29,098,520 A38E possibly damaging Het
Chrm2 A T 6: 36,523,420 I71F possibly damaging Het
Cntnap5c A G 17: 58,162,277 Q618R probably benign Het
Cog5 T A 12: 31,837,309 N476K probably benign Het
Dhx36 G A 3: 62,470,558 probably benign Het
Dnajb8 G T 6: 88,222,854 R124L possibly damaging Het
Dnajc16 A T 4: 141,763,563 probably null Het
Dzip1 T C 14: 118,883,394 D717G probably benign Het
Eps15 G T 4: 109,309,149 V80L probably damaging Het
Fmn1 G A 2: 113,444,467 probably benign Het
Gm12185 A G 11: 48,907,861 S602P probably damaging Het
Gm28539 T G 16: 18,954,780 probably benign Het
Grm3 T C 5: 9,512,290 N520S probably benign Het
Hivep2 A G 10: 14,142,244 N1825S probably damaging Het
Igfbp2 A G 1: 72,849,128 H143R probably benign Het
Igsf8 T G 1: 172,317,544 V146G possibly damaging Het
Kif13b T G 14: 64,714,113 S68A probably benign Het
Mrrf G A 2: 36,141,631 R53H possibly damaging Het
Ms4a6d G A 19: 11,601,885 T76I probably damaging Het
Pkd1l1 T C 11: 8,868,493 R1332G probably benign Het
Plekha1 A G 7: 130,877,839 Y29C probably damaging Het
Pnliprp1 A T 19: 58,734,730 H221L probably damaging Het
Pomt2 T C 12: 87,124,856 D380G probably damaging Het
Ppm1f C A 16: 16,910,971 T79N possibly damaging Het
Ppp4r3b A C 11: 29,211,782 T719P possibly damaging Het
Socs4 G A 14: 47,290,252 V215I probably benign Het
Spg11 A G 2: 122,094,456 probably null Het
Stk31 T A 6: 49,437,443 C459S probably benign Het
Ttn A G 2: 76,709,202 V26153A possibly damaging Het
Twf1 C T 15: 94,580,936 probably benign Het
Vrk3 A T 7: 44,769,647 K383M probably damaging Het
Wdr83 A T 8: 85,079,814 N118K probably damaging Het
Other mutations in Lrrc15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01720:Lrrc15 APN 16 30273320 missense probably benign 0.19
R0138:Lrrc15 UTSW 16 30273449 missense possibly damaging 0.63
R0317:Lrrc15 UTSW 16 30273743 missense probably benign
R0497:Lrrc15 UTSW 16 30272892 missense probably damaging 0.98
R0528:Lrrc15 UTSW 16 30273748 missense probably damaging 0.99
R1122:Lrrc15 UTSW 16 30273901 missense probably damaging 1.00
R1950:Lrrc15 UTSW 16 30273831 missense probably benign 0.21
R2898:Lrrc15 UTSW 16 30273786 missense probably benign 0.01
R4272:Lrrc15 UTSW 16 30273855 missense probably benign 0.06
R4839:Lrrc15 UTSW 16 30274268 missense probably benign 0.00
R5091:Lrrc15 UTSW 16 30273354 missense probably damaging 1.00
R5369:Lrrc15 UTSW 16 30272904 missense possibly damaging 0.93
R6076:Lrrc15 UTSW 16 30272988 missense probably benign 0.25
R6133:Lrrc15 UTSW 16 30274236 missense probably benign 0.11
R7017:Lrrc15 UTSW 16 30272962 missense probably benign 0.00
Z1176:Lrrc15 UTSW 16 30274252 missense probably benign 0.31
Posted On2012-12-06