Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00495:Lrrc15'

11824

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Lrrc15

Ensembl Gene

ENSMUSG00000052316

Gene Name

leucine rich repeat containing 15

Synonyms

5430427N11Rik

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL00495

Quality Score

Status

Chromosome

Chromosomal Location

30088120-30102072 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 30092848 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Phenylalanine at position 164 (I164F)

Ref Sequence

ENSEMBL: ENSMUSP00000066777 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000064606]

AlphaFold

Q80X72

Predicted Effect

possibly damaging
Transcript: ENSMUST00000064606
AA Change: I164F

PolyPhen 2 Score 0.899 (Sensitivity: 0.82; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000066777
Gene: ENSMUSG00000052316
AA Change: I164F

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
LRRNT	24	57	2.98e0	SMART
LRR	76	99	6.97e1	SMART
LRR_TYP	100	123	1.98e-4	SMART
LRR	124	147	4.08e0	SMART
LRR_TYP	148	171	2.4e-3	SMART
LRR_TYP	172	195	1.82e-3	SMART
LRR_TYP	196	219	1.18e-2	SMART
LRR_TYP	220	243	3.16e-3	SMART
LRR_TYP	245	267	3.39e-3	SMART
LRR_TYP	268	291	8.81e-2	SMART
LRR_TYP	292	315	9.5e-7	SMART
LRR_TYP	316	339	6.52e-5	SMART
LRR_TYP	340	363	7.78e-3	SMART
LRR_TYP	364	387	1.03e-2	SMART
LRR	388	411	8.48e0	SMART
LRRCT	423	474	1.11e-3	SMART
low complexity region	485	512	N/A	INTRINSIC
transmembrane domain	537	559	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 35 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ankk1	T	C	9: 49,327,143 (GRCm39)	T679A	probably benign	Het
Bhlhe40	T	A	6: 108,638,139 (GRCm39)	M33K	probably benign	Het
Cacna2d1	T	C	5: 16,575,607 (GRCm39)	S1059P	probably benign	Het
Cdkn1a	C	A	17: 29,317,494 (GRCm39)	A38E	possibly damaging	Het
Chrm2	A	T	6: 36,500,355 (GRCm39)	I71F	possibly damaging	Het
Cntnap5c	A	G	17: 58,469,272 (GRCm39)	Q618R	probably benign	Het
Cog5	T	A	12: 31,887,308 (GRCm39)	N476K	probably benign	Het
Dhx36	G	A	3: 62,377,979 (GRCm39)		probably benign	Het
Dnajb8	G	T	6: 88,199,836 (GRCm39)	R124L	possibly damaging	Het
Dnajc16	A	T	4: 141,490,874 (GRCm39)		probably null	Het
Dzip1	T	C	14: 119,120,806 (GRCm39)	D717G	probably benign	Het
Eps15	G	T	4: 109,166,346 (GRCm39)	V80L	probably damaging	Het
Fmn1	G	A	2: 113,274,812 (GRCm39)		probably benign	Het
Gm12185	A	G	11: 48,798,688 (GRCm39)	S602P	probably damaging	Het
Gm28539	T	G	16: 18,773,530 (GRCm39)		probably benign	Het
Grm3	T	C	5: 9,562,290 (GRCm39)	N520S	probably benign	Het
Hivep2	A	G	10: 14,017,988 (GRCm39)	N1825S	probably damaging	Het
Igfbp2	A	G	1: 72,888,287 (GRCm39)	H143R	probably benign	Het
Igsf8	T	G	1: 172,145,111 (GRCm39)	V146G	possibly damaging	Het
Kif13b	T	G	14: 64,951,562 (GRCm39)	S68A	probably benign	Het
Mrrf	G	A	2: 36,031,643 (GRCm39)	R53H	possibly damaging	Het
Ms4a6d	G	A	19: 11,579,249 (GRCm39)	T76I	probably damaging	Het
Pkd1l1	T	C	11: 8,818,493 (GRCm39)	R1332G	probably benign	Het
Plekha1	A	G	7: 130,479,569 (GRCm39)	Y29C	probably damaging	Het
Pnliprp1	A	T	19: 58,723,162 (GRCm39)	H221L	probably damaging	Het
Pomt2	T	C	12: 87,171,630 (GRCm39)	D380G	probably damaging	Het
Ppm1f	C	A	16: 16,728,835 (GRCm39)	T79N	possibly damaging	Het
Ppp4r3b	A	C	11: 29,161,782 (GRCm39)	T719P	possibly damaging	Het
Socs4	G	A	14: 47,527,709 (GRCm39)	V215I	probably benign	Het
Spg11	A	G	2: 121,924,937 (GRCm39)		probably null	Het
Stk31	T	A	6: 49,414,377 (GRCm39)	C459S	probably benign	Het
Ttn	A	G	2: 76,539,546 (GRCm39)	V26153A	possibly damaging	Het
Twf1	C	T	15: 94,478,817 (GRCm39)		probably benign	Het
Vrk3	A	T	7: 44,419,071 (GRCm39)	K383M	probably damaging	Het
Wdr83	A	T	8: 85,806,443 (GRCm39)	N118K	probably damaging	Het

Other mutations in Lrrc15

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01720:Lrrc15	APN	16	30,092,138 (GRCm39)	missense	probably benign	0.19
R0138:Lrrc15	UTSW	16	30,092,267 (GRCm39)	missense	possibly damaging	0.63
R0317:Lrrc15	UTSW	16	30,092,561 (GRCm39)	missense	probably benign
R0497:Lrrc15	UTSW	16	30,091,710 (GRCm39)	missense	probably damaging	0.98
R0528:Lrrc15	UTSW	16	30,092,566 (GRCm39)	missense	probably damaging	0.99
R1122:Lrrc15	UTSW	16	30,092,719 (GRCm39)	missense	probably damaging	1.00
R1950:Lrrc15	UTSW	16	30,092,649 (GRCm39)	missense	probably benign	0.21
R2898:Lrrc15	UTSW	16	30,092,604 (GRCm39)	missense	probably benign	0.01
R4272:Lrrc15	UTSW	16	30,092,673 (GRCm39)	missense	probably benign	0.06
R4839:Lrrc15	UTSW	16	30,093,086 (GRCm39)	missense	probably benign	0.00
R5091:Lrrc15	UTSW	16	30,092,172 (GRCm39)	missense	probably damaging	1.00
R5369:Lrrc15	UTSW	16	30,091,722 (GRCm39)	missense	possibly damaging	0.93
R6076:Lrrc15	UTSW	16	30,091,806 (GRCm39)	missense	probably benign	0.25
R6133:Lrrc15	UTSW	16	30,093,054 (GRCm39)	missense	probably benign	0.11
R7017:Lrrc15	UTSW	16	30,091,780 (GRCm39)	missense	probably benign	0.00
R9217:Lrrc15	UTSW	16	30,092,415 (GRCm39)	missense	probably damaging	1.00
R9507:Lrrc15	UTSW	16	30,092,829 (GRCm39)	missense	probably damaging	1.00
R9533:Lrrc15	UTSW	16	30,092,637 (GRCm39)	missense	possibly damaging	0.67
R9562:Lrrc15	UTSW	16	30,093,016 (GRCm39)	missense	probably damaging	1.00
R9565:Lrrc15	UTSW	16	30,093,016 (GRCm39)	missense	probably damaging	1.00
R9616:Lrrc15	UTSW	16	30,092,517 (GRCm39)	missense	probably damaging	1.00
R9641:Lrrc15	UTSW	16	30,093,006 (GRCm39)	missense	probably damaging	1.00
R9755:Lrrc15	UTSW	16	30,093,147 (GRCm39)	missense	possibly damaging	0.95
Z1176:Lrrc15	UTSW	16	30,093,070 (GRCm39)	missense	probably benign	0.31

Posted On

2012-12-06