Incidental Mutation 'IGL00790:Mrgpra4'
ID12076
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Mrgpra4
Ensembl Gene ENSMUSG00000067173
Gene NameMAS-related GPR, member A4
SynonymsMrgA4
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.057) question?
Stock #IGL00790
Quality Score
Status
Chromosome7
Chromosomal Location47980837-47982095 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 47981304 bp
ZygosityHeterozygous
Amino Acid Change Methionine to Lysine at position 183 (M183K)
Ref Sequence ENSEMBL: ENSMUSP00000084327 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000087092]
Predicted Effect possibly damaging
Transcript: ENSMUST00000087092
AA Change: M183K

PolyPhen 2 Score 0.537 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000084327
Gene: ENSMUSG00000067173
AA Change: M183K

DomainStartEndE-ValueType
Pfam:7tm_1 38 270 1.3e-10 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 29 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4921501E09Rik A G 17: 33,067,387 V147A probably damaging Het
AC139131.1 T G 7: 12,494,232 M702R probably damaging Het
Ankrd12 A T 17: 65,984,180 N1419K probably benign Het
Arhgef18 A G 8: 3,429,553 E79G probably damaging Het
Art4 T A 6: 136,854,495 Q216L probably damaging Het
Bbs4 T C 9: 59,324,065 D407G probably benign Het
Cherp A G 8: 72,468,246 I277T probably damaging Het
Cnot2 A G 10: 116,507,071 M119T probably benign Het
Disp2 T A 2: 118,786,278 C73S probably damaging Het
Dock4 T C 12: 40,834,391 S1686P probably damaging Het
Dsc1 C T 18: 20,094,896 G468S probably damaging Het
Duox2 T A 2: 122,292,300 D551V possibly damaging Het
Gmip T A 8: 69,817,011 Y585* probably null Het
Gnal A G 18: 67,134,289 probably null Het
Idh1 T G 1: 65,166,122 Q228P possibly damaging Het
Igsf10 A T 3: 59,319,517 I2245N probably damaging Het
Npr2 T A 4: 43,641,612 V472D possibly damaging Het
Pcdh7 A T 5: 57,721,464 N787I probably damaging Het
Ppp1r10 A T 17: 35,924,859 N111I probably damaging Het
Ppp3ca A G 3: 136,935,181 N508D probably benign Het
Rgs17 A G 10: 5,862,624 Q25P possibly damaging Het
Slco6d1 T A 1: 98,421,200 probably benign Het
Tab3 T A X: 85,621,604 N591K probably damaging Het
Tfcp2 T C 15: 100,513,178 probably benign Het
Them5 A T 3: 94,343,409 D93V probably damaging Het
Thoc5 T G 11: 4,918,147 V275G probably damaging Het
Trmt1l T C 1: 151,442,712 probably null Het
Zdbf2 G T 1: 63,306,514 V1351F possibly damaging Het
Zfp14 G T 7: 30,038,887 Y224* probably null Het
Other mutations in Mrgpra4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02083:Mrgpra4 APN 7 47981060 nonsense probably null
IGL02155:Mrgpra4 APN 7 47981544 missense probably damaging 0.99
IGL02577:Mrgpra4 APN 7 47981233 missense probably benign 0.10
IGL02674:Mrgpra4 APN 7 47980942 missense probably benign 0.09
IGL02696:Mrgpra4 APN 7 47981503 missense possibly damaging 0.96
R0357:Mrgpra4 UTSW 7 47981826 missense probably benign
R0543:Mrgpra4 UTSW 7 47981310 missense probably benign 0.00
R0677:Mrgpra4 UTSW 7 47980980 missense probably benign 0.00
R1163:Mrgpra4 UTSW 7 47981476 missense probably damaging 1.00
R1217:Mrgpra4 UTSW 7 47981337 missense probably benign 0.00
R2255:Mrgpra4 UTSW 7 47981775 missense possibly damaging 0.70
R4191:Mrgpra4 UTSW 7 47981119 missense probably benign 0.00
R4303:Mrgpra4 UTSW 7 47980936 missense probably benign 0.02
R4472:Mrgpra4 UTSW 7 47981791 missense probably benign 0.05
R4757:Mrgpra4 UTSW 7 47980938 missense probably damaging 1.00
R4976:Mrgpra4 UTSW 7 47981718 missense probably damaging 1.00
R5004:Mrgpra4 UTSW 7 47981787 missense probably benign 0.26
R5034:Mrgpra4 UTSW 7 47981569 missense probably benign 0.00
R5119:Mrgpra4 UTSW 7 47981718 missense probably damaging 1.00
R5722:Mrgpra4 UTSW 7 47981007 missense probably benign
R6800:Mrgpra4 UTSW 7 47981623 missense probably damaging 1.00
R7163:Mrgpra4 UTSW 7 47981490 missense probably benign 0.42
R7585:Mrgpra4 UTSW 7 47981629 missense probably benign 0.24
R7636:Mrgpra4 UTSW 7 47980973 missense possibly damaging 0.95
R8162:Mrgpra4 UTSW 7 47981473 missense probably damaging 1.00
X0028:Mrgpra4 UTSW 7 47981420 nonsense probably null
Posted On2012-12-06