Incidental Mutation 'IGL00769:Mrgprb4'
ID 12078
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Mrgprb4
Ensembl Gene ENSMUSG00000070550
Gene Name MAS-related GPR, member B4
Synonyms MrgB4
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL00769
Quality Score
Status
Chromosome 7
Chromosomal Location 47847961-47848926 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 47848649 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Valine at position 93 (D93V)
Ref Sequence ENSEMBL: ENSMUSP00000091952 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000094388]
AlphaFold Q91ZC0
Predicted Effect probably benign
Transcript: ENSMUST00000094388
AA Change: D93V

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000091952
Gene: ENSMUSG00000070550
AA Change: D93V

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srx 37 215 6.4e-8 PFAM
Pfam:7tm_1 46 274 7.6e-12 PFAM
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a null allele are viable, fertile and overtly normal with no apparent alterations in the pattern of axonal innervation of the epidermis. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 24 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9930111J21Rik1 A G 11: 48,839,039 (GRCm39) V516A possibly damaging Het
Ambp G A 4: 63,062,402 (GRCm39) T279I probably damaging Het
Ankrd28 A G 14: 31,465,322 (GRCm39) V285A possibly damaging Het
Arfgef3 A G 10: 18,536,352 (GRCm39) S220P probably benign Het
Atp9b G T 18: 80,956,068 (GRCm39) H129N probably benign Het
Cdh10 C A 15: 18,985,185 (GRCm39) P283Q possibly damaging Het
Cep295 A G 9: 15,237,440 (GRCm39) S1941P probably damaging Het
Dmbt1 T A 7: 130,684,230 (GRCm39) S575R probably damaging Het
Dock11 A G X: 35,267,715 (GRCm39) N796S possibly damaging Het
Enam A T 5: 88,649,343 (GRCm39) Y284F possibly damaging Het
F8 A T X: 74,377,786 (GRCm39) probably benign Het
Fbxo42 C T 4: 140,907,760 (GRCm39) T140M probably damaging Het
Galnt13 G A 2: 54,770,116 (GRCm39) E303K probably benign Het
Minar2 T C 18: 59,205,349 (GRCm39) S88P probably damaging Het
Msl3 T A X: 167,451,744 (GRCm39) E215V probably damaging Het
Pglyrp3 A T 3: 91,921,929 (GRCm39) probably benign Het
Prdx1 G A 4: 116,550,162 (GRCm39) D115N probably benign Het
Psd3 A T 8: 68,361,331 (GRCm39) probably benign Het
Rundc1 A G 11: 101,325,100 (GRCm39) D602G probably damaging Het
Slc4a1ap T G 5: 31,711,121 (GRCm39) Y742D probably damaging Het
Spmap1 A G 11: 97,662,407 (GRCm39) F155S probably damaging Het
Ugt1a6a C T 1: 88,066,772 (GRCm39) P193S probably damaging Het
Vmn2r96 G A 17: 18,804,081 (GRCm39) V252M probably benign Het
Wdr53 G A 16: 32,075,315 (GRCm39) W173* probably null Het
Other mutations in Mrgprb4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02745:Mrgprb4 APN 7 47,848,106 (GRCm39) missense probably damaging 0.97
R0718:Mrgprb4 UTSW 7 47,848,301 (GRCm39) missense probably benign 0.10
R0849:Mrgprb4 UTSW 7 47,848,868 (GRCm39) missense probably benign 0.24
R1526:Mrgprb4 UTSW 7 47,848,159 (GRCm39) nonsense probably null
R2857:Mrgprb4 UTSW 7 47,848,084 (GRCm39) missense possibly damaging 0.91
R2859:Mrgprb4 UTSW 7 47,848,084 (GRCm39) missense possibly damaging 0.91
R4355:Mrgprb4 UTSW 7 47,848,449 (GRCm39) missense possibly damaging 0.63
R5354:Mrgprb4 UTSW 7 47,848,077 (GRCm39) missense probably benign 0.07
R5636:Mrgprb4 UTSW 7 47,848,218 (GRCm39) missense probably benign 0.02
R5715:Mrgprb4 UTSW 7 47,848,787 (GRCm39) missense probably damaging 1.00
R6180:Mrgprb4 UTSW 7 47,848,574 (GRCm39) missense probably damaging 1.00
R6277:Mrgprb4 UTSW 7 47,848,649 (GRCm39) missense probably benign
R7092:Mrgprb4 UTSW 7 47,847,984 (GRCm39) missense probably benign 0.01
R7301:Mrgprb4 UTSW 7 47,848,506 (GRCm39) missense probably damaging 0.99
R7779:Mrgprb4 UTSW 7 47,848,895 (GRCm39) missense probably benign 0.19
R8077:Mrgprb4 UTSW 7 47,848,203 (GRCm39) missense probably benign 0.00
R8292:Mrgprb4 UTSW 7 47,848,554 (GRCm39) missense probably damaging 1.00
R8429:Mrgprb4 UTSW 7 47,848,173 (GRCm39) missense probably benign 0.01
R9000:Mrgprb4 UTSW 7 47,848,769 (GRCm39) missense probably damaging 1.00
R9006:Mrgprb4 UTSW 7 47,848,343 (GRCm39) missense probably benign 0.12
R9106:Mrgprb4 UTSW 7 47,848,679 (GRCm39) missense probably benign 0.43
R9717:Mrgprb4 UTSW 7 47,848,583 (GRCm39) missense possibly damaging 0.96
Z1088:Mrgprb4 UTSW 7 47,848,430 (GRCm39) missense possibly damaging 0.78
Posted On 2012-12-06